Protein Alignment CG42673 and DAB2

DIOPT Version :10

• Sequence 1: NP_729510.1
• Gene: CG42673 / 39111
• FlyBaseID: FBgn0261555
• Length: 904
• Species: Drosophila melanogaster
• Sequence 2: NP_001334.2
• Gene: DAB2 / 1601
• HGNCID: 2662
• Length: 770
• Species: Homo sapiens
• Alignment Length: 579
• Identity: 116/579 - (20%)
• Similarity: 176/579 - (30%)
• Gaps: 219/579 - (37%)

  Fly   354 QAMRIVRTVGQAFEVCHKFNLHKNSLEPNDERSDISSSELLDVEQISEQQLSEDGE----RGG-- 412
            ||..:|..:...|:|.  :|:.|.    .:|:..|..:... ||..||..:..|.:    :.|
Human   154 QAEPLVVDLKDLFQVI--YNVKKK----EEEKKKIEEASKA-VENGSEALMILDDQTNKLKSGVD 211

  Fly   413 -----GDNETPKKEHLAITPDLNHTQPQRPNHLDIMPSHSSLRKSNSLLCDVDDKSPGSPSSPRS 472
                 ||..||        ||||                                      ||
Human   212 QMDLFGDMSTP--------PDLN--------------------------------------SP-- 228

  Fly   473 EITQLKDQLEAQALQTRQALGQLMLVREQLISETNARIEAQARTQQLLQQNRELLEHLASLGAYN 537
              |:.||               ::||      :.|:.|:.   .|..|::|..|...:.|.....
Human   229 --TESKD---------------ILLV------DLNSEIDT---NQNSLRENPFLTNGITSCSLPR 267

  Fly   538 EQQTAGLT-----SANIGMAP-------------QQSQLQMLLQATSNNNNLATINQQISNLGSI 584
            ....|...     |||:...|             |..|     ...|:.::|.:.:|:..|..|.
Human   268 PTPQASFLPENAFSANLNFFPTPNPDPFRDDPFTQPDQ-----STPSSFDSLKSPDQKKENSSSS 327

  Fly   585 NQQLTS--LSHQLSGLNQQSQHLQNLQQQQQQQ---------QQQQQQQTQ---------AAPTA 629
            :..|::  |:..:....||...:.|...:|:.|         |.|...:||         .....
Human   328 STPLSNGPLNGDVDYFGQQFDQISNRTGKQEAQAGPWPFSSSQTQPAVRTQNGVSEREQNGFSVK 392

  Fly   630 ATPPPAAGGSSPYPSMSALQSISNQLQQQQQQQQQDALSKDLFQVNQEL------------LNRL 682
            ::|.|..|  ||...:|....:...|:...|....|:::  :....|..            .|.|
Human   393 SSPNPFVG--SPPKGLSIQNGVKQDLESSVQSSPHDSIA--IIPPPQSTKPGRGRRTAKSSANDL 453

  Fly   683 QALNLNANP-----GQSQPTPSATAHNSFFYVNPLSC------TPATPNNNAGG-------AGGF 729
            .|.::.|.|     ||:.||...||    ...|||..      .|..|....||       ||.:
Human   454 LASDIFAPPVSEPSGQASPTGQPTA----LQPNPLDLFKTSAPAPVGPLVGLGGVTVTLPQAGPW 514

  Fly   730 N------------------------------FLTSPAATGTLTPSPLGTMNRNSFAGSSSLNEDI 764
            |                              |.||||.:|...|||        ||.|:.....:
Human   515 NTASLVFNQSPSMAPGAMMGGQPSGFSQPVIFGTSPAVSGWNQPSP--------FAASTPPPVPV 571

  Fly   765 ----RLSIEQNLNNLEEQLKAAVSNGNLAGLACGGSTSTRDTSRSSSTLDSPSSPRLRS 819
                ..|:..|..:....|    .|...:.:....:.||:..|..||.|.:|..|..|:
Human   572 VWGPSASVAPNAWSTTSPL----GNPFQSNIFPAPAVSTQPPSMHSSLLVTPPQPPPRA 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42673	NP_729510.1	PH-like	<352..386	CDD:473070	8/31 (26%)
DAB2	NP_001334.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..38
		PTB_Dab	35..172	CDD:269926	5/19 (26%)
		Required for localization to clathrin-coated pits. /evidence=ECO:0000250	230..447		44/249 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	284..482		40/210 (19%)
		DPF 1	293..295		0/1 (0%)
		DPF 2	298..300		0/1 (0%)
		Sufficient for interaction with GRB2. /evidence=ECO:0000250	604..732		9/23 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	604..629		9/23 (39%)
		Required for interaction with CSK. /evidence=ECO:0000250	619..627		3/8 (38%)
		Required for interaction with MYO6. /evidence=ECO:0000250	649..770
		Required for interaction with GRB2 and CSK. /evidence=ECO:0000250	663..671
		Sufficient for interaction with SH3KBP1 SH3 domain. /evidence=ECO:0000250	709..725
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	742..770