Protein Alignment CG42673 and DAB1

DIOPT Version :10

• Sequence 1: NP_729510.1
• Gene: CG42673 / 39111
• FlyBaseID: FBgn0261555
• Length: 904
• Species: Drosophila melanogaster
• Sequence 2: NP_066566.3
• Gene: DAB1 / 1600
• HGNCID: 2661
• Length: 555
• Species: Homo sapiens
• Alignment Length: 675
• Identity: 129/675 - (19%)
• Similarity: 211/675 - (31%)
• Gaps: 227/675 - (33%)

  Fly   201 SNGDVL--KARLKFK------RLPGDH---------------YEASPEALRRAHLLHQRSEQRHQ 242
            :.||.|  .:.:|.|      |..|:|               ::....||:..|.:|:.|
Human    55 ARGDKLCQDSMMKLKGVVAGARSKGEHKQKIFLTISFGGIKIFDEKTGALQHHHAVHEIS----- 114

  Fly   243 LQRRKSLSDQQSSSSLSSGGGGGGNANGSIMLERPKTDKPRKKLSFREPIIAGDQILPLILSEQR 307
             ...|.::|.::...:.   |..||.....:          |.....||:|...:.|..::.|.:
Human   115 -YIAKDITDHRAFGYVC---GKEGNHRFVAI----------KTAQAAEPVILDLRDLFQLIYELK 165

  Fly   308 QARQRRRSSPLERSRVGLAIADCDNLCNNRTKDAISCGCATSDPESQAMRIVRTVGQAFEVCH-- 370
            |..:      ||:.      |..|..|.......|    ...|.|....:.:     .||..|
Human   166 QREE------LEKK------AQKDKQCEQAVYQTI----LEEDVEDPVYQYI-----VFEAGHEP 209

  Fly   371 ------KFNLHKNSLEPNDERS----DISSSELLDVEQISEQQLSEDGERGGGDNETPKKEHLAI 425
                  :.|:::   .|..::.    |:..|:  .|..:::.:|.       ||..||
Human   210 IRDPETEENIYQ---VPTSQKKEGVYDVPKSQ--PVSAVTQLELF-------GDMSTP------- 255

  Fly   426 TPDLNHTQPQRPNHLDIMPSHSSLRKSNSLL---CDVDDKSP-GSPSSPRSEITQLKDQLEAQAL 486
             ||:  |.|..|    ..|..:.:..|:..|   .||....| |:.:.|...:        |...
Human   256 -PDI--TSPPTP----ATPGDAFIPSSSQTLPASADVFSSVPFGTAAVPSGYV--------AMGA 305

  Fly   487 QTRQALGQLMLVREQLISETNARIEAQARTQQLLQQNRELLEHLASLGAYNEQQTAGLTSANIGM 551
            ......||..||::|::      :.||....|::...:.:.  ....|.:...|....|.|  |.
Human   306 VLPSFWGQQPLVQQQMV------MGAQPPVAQVMPGAQPIA--WGQPGLFPATQQPWPTVA--GQ 360

  Fly   552 AP----QQSQLQMLLQATSNNNNLATINQQISNLGSINQQLTSLSHQLSGLNQQSQHLQNLQQQQ 612
            .|    ..:|..|.|.|                 ......||.|: .:.|.:..::.    ..|.
Human   361 FPPAAFMPTQTVMPLPA-----------------AMFQGPLTPLA-TVPGTSDSTRS----SPQT 403

  Fly   613 QQQQQQQQQQTQAAPTAATPPPAAGGSSPYPSMS----ALQSISNQLQQQQQQQQQDALSKDLFQ 673
            .:.:|:..::|......|.|||........||::    |..|..|::     ...||....|.|.
Human   404 DKPRQKMGKETFKDFQMAQPPPVPSRKPDQPSLTCTSEAFSSYFNKV-----GVAQDTDDCDDFD 463

  Fly   674 VNQELLNRLQALNLNANPGQSQPTPSATAHNSFFYVNPLSCTPATPNNNAGGAGGFNFLTSPAAT 738
            ::|        |||                           ||.|.             |:|:..
Human   464 ISQ--------LNL---------------------------TPVTS-------------TTPSTN 480

  Fly   739 GTLTPSPLGTMNRNSFAGSSS--LNEDIRLSIEQNLNNLEEQLKAAVSNGNLAGLACGGSTSTRD 801
            ...||:|..:....|.|..:|  ..:||.....::.:..|||                   ...|
Human   481 SPPTPAPRQSSPSKSSASHASDPTTDDIFEEGFESPSKSEEQ-------------------EAPD 526

  Fly   802 TSRSSSTLDSPSSPRLRSSNNNISP 826
            .|::||..|....|....|.:||||
Human   527 GSQASSNSDPFGEPSGEPSGDNISP 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42673	NP_729510.1	PH-like	<352..386	CDD:473070	6/41 (15%)
DAB1	NP_066566.3	PTB_Dab	25..174	CDD:269926	27/149 (18%)
		PHA03247	<235..437	CDD:223021	52/264 (20%)