Protein Alignment CG42673 and Dab2

DIOPT Version :10

• Sequence 1: NP_729510.1
• Gene: CG42673 / 39111
• FlyBaseID: FBgn0261555
• Length: 904
• Species: Drosophila melanogaster
• Sequence 2: NP_075607.2
• Gene: Dab2 / 13132
• MGIID: 109175
• Length: 766
• Species: Mus musculus
• Alignment Length: 918
• Identity: 173/918 - (18%)
• Similarity: 290/918 - (31%)
• Gaps: 280/918 - (30%)

  Fly    44 SKVNMTKVQSQPAEQQASVSTVTPAE--KSSEV--HYHKNIFRSGGGLIRDILVG---------- 94
            ::|..:....|| :|||:....:..|  |.||.  .|....|:..|...:..|:|
Mouse     3 NEVETSTTNGQP-DQQAAPKAPSKKEKKKGSEKTDEYLLARFKGDGVKYKAKLIGIDDVPDARGD 66

  Fly    95 ----DKNLQLKDKPPQSPVPSHKKKQKHLSR---NKSLD----IRELIGCVERE----------- 137
                |..::||     ....:.:.:.:|..|   |.||.    |.|..|.:|.|
Mouse    67 KMSQDSMMKLK-----GMAAAGRSQGQHKQRIWVNISLSGIKIIDEKTGVIEHEHPVNKISFIAR 126

  Fly   138 -------MAPATGGGPVSQPPRFIDDTYIDHKPKHILFNDDENTVYIIKKEQPVAKSSHKASNST 195
                   .....||  ..|...|...|....:|..:...|....:|.:||::...|...:|:.:.
Mouse   127 DVTDNRAFGYVCGG--EGQHQFFAIKTGQQAEPLVVDLKDLFQVIYNVKKKEEDKKKVEEANKAE 189

  Fly   196 SNAAQS------NGDVLKARLKFKRLPGDHYEA----SPEALRRAHLLHQRSE---QRHQLQRRK 247
            .|.:::      ..:.||..:....|.||....    ||...:...|:...||   .::.|:...
Mouse   190 ENGSEALMTLDDQANKLKLGVDQMDLFGDMSTPPDLNSPTESKDILLVDLNSEIDTNQNSLRENP 254

  Fly   248 SLSDQQSSSSLSSGGGGGGNANGSIMLERPKTDK---PRKKLS-------------FR-EPIIAG 295
            .|::..:|.|                |.|||...   |....|             || :|....
Mouse   255 FLTNGVTSCS----------------LPRPKPQASFLPENAFSANLNFFPTPNPDPFRDDPFAQP 303

  Fly   296 DQILP-----LILSEQRQARQRRRSSPLERSRVGLAIADCD------NLCNNRTKDAISCGCATS 349
            ||..|     |...:|::|.....|:|..:   |....|.|      :..:|||....:.|....
Mouse   304 DQSAPSSFDSLTSPDQKKASLSSSSTPQSK---GPLNGDTDYFGQQFDQLSNRTGKPEAQGGPWP 365

  Fly   350 DPESQAMRIVRTV-GQAFEVCHKFNLH-----------KNSLEPNDERSDISSSELLDVEQISEQ 402
            .|.||..:.|||. |.:....:.|::.           |....||..:.|:.||.
Mouse   366 YPSSQTQQAVRTQNGVSEREQNGFHIKSSPNPFVGSPPKGLSVPNGVKQDLESSV---------- 420

  Fly   403 QLSEDGERGGGDNETPKKEHLAITPDLNHTQPQRPNHLDIMPSHSSLRKSNSLLC-DVDDKSP-- 464
                         ::...:.:||.|....|:|.|..       .::...:|.||. |:....|
Mouse   421 -------------QSSAHDSIAIIPPPQSTKPGRGR-------RTAKSSANDLLASDIFASEPPG 465

  Fly   465 -----GSPSSPRSEITQLKDQLEAQALQTRQALGQLMLVREQLISETNARIEAQARTQQLLQQNR 524
                 |.|:.|:|....|........:.....||.:.:...|          |...|..:...:.
Mouse   466 QMSPTGQPAVPQSNFLDLFKGNAPAPVGPLVGLGTVPVTPPQ----------AGPWTPVVYSPST 520

  Fly   525 ELLEHLASLG---AYNEQQTAGLTSANIGMAPQQSQLQMLLQATSNNNNLAT------------I 574
            .::......|   ::.:....|.|.|              :|..:.:.:.||            .
Mouse   521 TVVPGAIISGQPPSFGQPLVFGTTPA--------------VQVWNQSPSFATPASPPPPTVWCPT 571

  Fly   575 NQQISNLGSINQQLTSLSHQLSGLNQQSQHLQNLQQQQQQQQQQQQQQTQAAPTAATPPPAAGGS 639
            .....|..|....|        |...||.::........|...|....:..| |...|||..|..
Mouse   572 TSVAPNAWSSTSPL--------GNPFQSNNIFPPPTMSTQSSPQPMMSSVLA-TPPQPPPRNGPL 627

  Fly   640 SPYPS--MSALQSISNQLQQQQQQQQQDALSKDLFQVNQELLNRLQALNLNANPGQSQPTPSATA 702
            ...||  .:.|..:.::..::.::..:|      ||:.|..|       :.:..|::.|:.:::|
Mouse   628 KDIPSDAFTGLDPLGDKEVKEVKEMFKD------FQLRQPPL-------VPSRKGETPPSGTSSA 679

  Fly   703 HNSFFYVNPLSCTPATPNNNAGGAGGFNFLTSPAATGTLTPSPLGTMNRNSFAGSSSLNEDIRLS 767
            .:|:|            ||..|                   .|...::.:.|            .
Mouse   680 FSSYF------------NNKVG-------------------IPQEHVDHDDF------------D 701

  Fly   768 IEQNLNNLEEQLKAAVSNGNLAGLACGGSTSTRDTSRSSSTLDSPSSPRLRSSNNNI--SPGSSN 830
            ..|.||.:.|..|.|...|.|.|           |..:.::|::|.|....|||.::  .|.||:
Mouse   702 ANQLLNKINEPPKPAPRQGVLLG-----------TKSADNSLENPFSKGFSSSNPSVVSQPASSD 755

  Fly   831 GNQNHNNN 838
            .:::...|
Mouse   756 PHRSPFGN 763

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42673	NP_729510.1	PH-like	<352..386	CDD:473070	10/45 (22%)
Dab2	NP_075607.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36		10/33 (30%)
		PTB_Dab	35..171	CDD:269926	25/142 (18%)
		Required for localization to clathrin-coated pits	230..447		51/265 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	284..482		47/230 (20%)
		PHA03247	<288..608	CDD:223021	67/384 (17%)
		DPF 1	293..295		0/1 (0%)
		DPF 2	298..300		0/1 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	596..630		8/34 (24%)
		Sufficient for interaction with GRB2. /evidence=ECO:0000269|PubMed:9569023	600..730		36/197 (18%)
		Required for interaction with CSK. /evidence=ECO:0000250	617..625		3/7 (43%)
		Required for interaction with MYO6. /evidence=ECO:0000269|PubMed:11906161	647..766		35/184 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	659..683		5/30 (17%)
		Required for interaction with GRB2 and CSK. /evidence=ECO:0000250	661..669		1/14 (7%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	699..766		21/88 (24%)
		Sufficient for interaction with SH3KBP1 SH3 domain	707..723		5/15 (33%)