DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3408 and LRRC59

DIOPT Version :9

Sequence 1:	NP_648328.1	Gene:	CG3408 / 39107	FlyBaseID:	FBgn0036008	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	NP_060979.2	Gene:	LRRC59 / 55379	HGNCID:	28817	Length:	307	Species:	Homo sapiens

Alignment Length:	324	Identity:	106/324 - (32%)
Similarity:	158/324 - (48%)	Gaps:	40/324 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPKPGDKAKVKVNVKERVVDETCDLSLSELSEIPVREIASFKRVTVLDLSSNRLVNLGKNFSILT 65
            |.|.|.|..   |:::::.....|||||:|:|:||:|:|:..:.|:||||.|:|..|..:|..||
Human     1 MTKAGSKGG---NLRDKLDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLT 62

  Fly    66 RLVRLDLSKNQIKFLPEDFGQLEQLRHLDLYNNCLEHLPISFGQLRRLRYLDLKGNPLTPAWEKI 130
            .||:||||||:::.||.|||:|..|:||||.||.|..||:||.||:.|::||||.|||.|...|:
Human    63 HLVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKV 127

  Fly   131 VGCCSTQKDCQQAAKNTVSICANYKPEFI-------ERERL----AAQESQKMAGAGDSSANAVQ 184
            .|.|..:|.|:|        |||...:.:       ||||.    ..:|::|...|...:..|.:
Human   128 AGDCLDEKQCKQ--------CANKVLQHMKAVQADQERERQRRLEVEREAEKKREAKQRAKEAQE 184

  Fly   185 TNGGAAGGKKSTKPNNKKAKAK-----KLAGGGDNELTIKPVNAVGSGGSGAIALGSKSTQKNNQ 244
            ..     .:|..|...|:.:.|     |.|.....:...|..|......||       |..:...
Human   185 RE-----LRKREKAEEKERRRKEYDALKAAKREQEKKPKKEANQAPKSKSG-------SRPRKPP 237

  Fly   245 KKKNSKGDSWLNLLSRAALSSLVSFLVLFIINLLIIYMIMFKNPDIADKLVEYI-PHQYRDWIL 307
            .:|:::..:.|.||....|..:...||...:..|....:......|.|..|:.: .|:...|:|
Human   238 PRKHTRSWAVLKLLLLLLLFGVAGGLVACRVTELQQQPLCTSVNTIYDNAVQGLRRHEILQWVL 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3408	NP_648328.1	LRR_RI	<43..>124	CDD:238064	46/80 (58%)
		leucine-rich repeat	44..66	CDD:275378	10/21 (48%)
		LRR_8	65..123	CDD:290566	35/57 (61%)
		leucine-rich repeat	67..89	CDD:275378	14/21 (67%)
		leucine-rich repeat	90..112	CDD:275378	14/21 (67%)
		leucine-rich repeat	113..124	CDD:275378	7/10 (70%)
LRRC59	NP_060979.2	LRR 1	10..31		8/20 (40%)
		LRR	<18..>120	CDD:227223	56/101 (55%)
		leucine-rich repeat	19..40	CDD:275378	11/20 (55%)
		LRR 2	40..62		9/21 (43%)
		leucine-rich repeat	41..63	CDD:275378	10/21 (48%)
		LRR 3	63..84		13/20 (65%)
		leucine-rich repeat	64..86	CDD:275378	14/21 (67%)
		LRR 4	86..107		12/20 (60%)
		leucine-rich repeat	87..109	CDD:275378	14/21 (67%)
		LRR 5	109..128		10/18 (56%)
		InfB	135..>243	CDD:392272	26/127 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..241		19/102 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11539
eggNOG	1	0.900	-	-		E2759_KOG0473
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	143	1.000	Inparanoid score	I4467
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007322
OrthoInspector	1	1.000	-	-		oto88809
orthoMCL	1	0.900	-	-		OOG6_108305
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4209
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.750