DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3408 and Lrrc59

DIOPT Version :9

Sequence 1:	NP_648328.1	Gene:	CG3408 / 39107	FlyBaseID:	FBgn0036008	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	NP_001008281.1	Gene:	Lrrc59 / 287633	RGDID:	1305092	Length:	307	Species:	Rattus norvegicus

Alignment Length:	344	Identity:	111/344 - (32%)
Similarity:	162/344 - (47%)	Gaps:	80/344 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPKPGDKAKVKVNVKERVVDETCDLSLSELSEIPVREIASFKRVTVLDLSSNRLVNLGKNFSILT 65
            |.|.|.|..   |:::::.....|||||:|:|:||:|:|:..:.||||||.|:|..|..:|..||
  Rat     1 MTKTGSKGG---NLRDKLDGNELDLSLSDLNEVPVKELAALPKATVLDLSCNKLSTLPSDFCGLT 62

  Fly    66 RLVRLDLSKNQIKFLPEDFGQLEQLRHLDLYNNCLEHLPISFGQLRRLRYLDLKGNPLTPAWEKI 130
            .||:||||||:::.||.|||:|..|:||||.||.|..||:||.||:.|::||||.|||.|...|:
  Rat    63 HLVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNRLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKV 127

  Fly   131 VGCCSTQKDCQQAAKNTVSICANYKPEFI-------ERERLAAQESQKMAGAGDSSANAVQTNGG 188
            .|.|..:|.|:|        |||...:.:       ||||....|.::
  Rat   128 AGDCLDEKQCKQ--------CANKVLQHMKAVQADQERERQRRLEVER----------------- 167

  Fly   189 AAGGKKSTKPNNKKAKAKKL---AGGGDNELTIKPVNAVGSGGSGAIALGSKSTQ------KNNQ 244
            .|..|:..|...|:||.::|   ....:.|...|..:|         ...||..|      :.||
  Rat   168 EAEKKREAKQQAKEAKERELRKREKAEEKERRRKEYDA---------QKASKREQEKKPKKETNQ 223

  Fly   245 KKKNSKGD------------SWLNLLSRAALSSLVSFLVLFIINLLIIYMI--MFKNP------D 289
            ..|:..|.            ||      |.|..|:..|:|.:...|::..:  :.:.|      .
  Rat   224 APKSKSGSRPRKPPPRKHNRSW------AVLKGLLLLLLLCVAGGLVVCRVTGLQQQPLCTSVNA 282

  Fly   290 IADKLVEYI-PHQYRDWIL 307
            |.|..|:.: .|:...|:|
  Rat   283 IYDNAVQGLRHHEILQWVL 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3408	NP_648328.1	LRR_RI	<43..>124	CDD:238064	47/80 (59%)
		leucine-rich repeat	44..66	CDD:275378	11/21 (52%)
		LRR_8	65..123	CDD:290566	35/57 (61%)
		leucine-rich repeat	67..89	CDD:275378	14/21 (67%)
		leucine-rich repeat	90..112	CDD:275378	14/21 (67%)
		leucine-rich repeat	113..124	CDD:275378	7/10 (70%)
Lrrc59	NP_001008281.1	LRR 1	10..31		8/20 (40%)
		LRR	<18..>120	CDD:227223	57/101 (56%)
		leucine-rich repeat	19..40	CDD:275378	11/20 (55%)
		LRR 2	40..62		10/21 (48%)
		leucine-rich repeat	41..63	CDD:275378	11/21 (52%)
		LRR 3	63..84		13/20 (65%)
		leucine-rich repeat	64..86	CDD:275378	14/21 (67%)
		LRR 4	86..107		12/20 (60%)
		leucine-rich repeat	87..109	CDD:275378	14/21 (67%)
		LRR 5	109..128		10/18 (56%)
		InfB	135..>243	CDD:392272	28/141 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..242		22/117 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	51	1.000	Domainoid score	I11260
eggNOG	1	0.900	-	-		E2759_KOG0473
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	141	1.000	Inparanoid score	I4395
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007322
OrthoInspector	1	1.000	-	-		oto95941
orthoMCL	1	0.900	-	-		OOG6_108305
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.720