DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment path and Slc38a4

DIOPT Version :9

Sequence 1:	NP_001261634.1	Gene:	path / 39106	FlyBaseID:	FBgn0036007	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_001344987.1	Gene:	Slc38a4 / 69354	MGIID:	1916604	Length:	547	Species:	Mus musculus

Alignment Length:	510	Identity:	100/510 - (19%)
Similarity:	173/510 - (33%)	Gaps:	171/510 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 DNPHP--TTDNETLTHLLKASLGTGILGMPFAFMCSGLIMGIFSTIFTAFICTHCSYVLVKC--- 112
            |..||  |:...:..:|..|.:|:||||:.:|...:|:|:.|...:..|.:..:..::|:|.
Mouse    68 DEHHPGMTSFGMSSFNLSNAIMGSGILGLSYAMANTGIILFIIMLLTVAILSLYSVHLLLKTAKE 132

  Fly   113 GHKLYYRTRRTKMTFAEIAEAAFQKGPKWCRGFAPVAKFSILFGLFLTYFGTCSVYTVIVASNFE 177
            |..|.|.         ::.|.||    .|      ..|......:.:...|..|.|..|:.....
Mouse   133 GGSLIYE---------KLGEKAF----GW------PGKIGAFISITMQNIGAMSSYLFIIKYELP 178

  Fly   178 QLIS------------YWTGTAVSLRMLICIMLVPLILIAWVPNLKYLAPVSMVANVFMGLGLGI 230
            ::|.            |..|..:.|.:.:.|:| ||.|:..:..|.|.:..|:...||.   :.:
Mouse   179 EVIRAFMGLEENTGEWYLNGNYLVLFVSVGIIL-PLSLLKNLGYLGYTSGFSLSCMVFF---VSV 239

  Fly   231 TFYYLVQ---DLPPVEER-----------------------------------------ESVVWS 251
            ..|...|   .||.::..                                         |..|..
Mouse   240 VIYKKFQIPCPLPALDHNNGNLTFNNTLPIHMISLPNDSESSGVNFMMDYAHHNPAGLDEKQVAG 304

  Fly   252 TL----------------PQFF---SITIFAMEAIGV-------VMPLENNMKTPQSFLGICGVL 290
            .|                |::|   |.|.:|:..:..       |:|:.:.:| .:|...:..|.
Mouse   305 PLHSNGVEYEAQGAEKCQPKYFVFNSRTAYAIPILAFAFVCHPEVLPIYSELK-DRSRRKMQTVS 368

  Fly   291 SQGMSGVTLIYMLLGFLGYLR-YGSATGE------------------------SITLNLPIEEWP 330
            :..:||:.::|:|....|||. ||....|                        ::||.:||..:|
Mouse   369 NISISGMLVMYLLAALFGYLSFYGDVEDELLHAYSKVYTFDTALLMVRLAVLVAVTLTVPIVLFP 433

  Fly   331 AQTVKVLISLAVYCTFGLQFFVCLEIIWDGIKEKCKKRPTLVNYVLRTVLVTAAVVLAVAVPTIG 395
            .:|..:.:           .|......|            |.::.:..:::....:|.:.||||.
Mouse   434 IRTSVITL-----------LFPRKPFSW------------LKHFGIAAIIIALNNILVILVPTIK 475

  Fly   396 PFMGLIGAFCFSILGLIFPVVIELIVHWESGFGKYNWILWKNAIITLCGIGALVF 450
            ...|.|||...::|..|.|...            |..::.|..:.:...||||||
Mouse   476 YIFGFIGASSATMLIFILPAAF------------YLKLVKKEPLRSPQKIGALVF 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
path	NP_001261634.1	SLC5-6-like_sbd	56..456	CDD:294310	99/507 (20%)
path	NP_001261634.1	SdaC	67..445	CDD:223884	90/487 (18%)
Slc38a4	NP_001344987.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
Slc38a4	NP_001344987.1	SLC5-6-like_sbd	75..535	CDD:382020	97/503 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910