DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment path and slc38a2

DIOPT Version :9

Sequence 1:	NP_001261634.1	Gene:	path / 39106	FlyBaseID:	FBgn0036007	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_001038569.1	Gene:	slc38a2 / 566537	ZFINID:	ZDB-GENE-030131-9659	Length:	504	Species:	Danio rerio

Alignment Length:	481	Identity:	108/481 - (22%)
Similarity:	184/481 - (38%)	Gaps:	112/481 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 NPHPTTDNETLTHLLKASLGTGILGMPFAFMCSGLIMGIFSTIFTAFICTHCSYVLVKC---GHK 115
            :|...:...::.:|..|.:|:||||:.:|...:|:.|.:...:..|....:..::|:|.   |..
Zfish    70 SPGSASFGMSVFNLGNAIMGSGILGLSYAMANTGIAMFVILLVAVAIFSLYSVHLLLKTANEGGS 134

  Fly   116 LYYRTRRTKMTFAEIAEAAFQKGPKWCRGFAPVAKFSILFGLFLTYFGTCSVYTVIVASNFEQLI 180
            |.|.                |.|.|   .|....|.:....:.:..||..:.|..||......:|
Zfish   135 LVYE----------------QLGYK---AFGIPGKLAASCSITMQNFGAMASYLYIVKYELPIVI 180

  Fly   181 S----------YWTGTAVSLRMLICIMLVPLILIAWVPNLKYLAPVSMVANVFMGLGLGITFYYL 235
            .          |..|..:.|.:.:.|:| ||.|:..:..|.|.:..|::..||.   |.:..|..
Zfish   181 RAFLDSNDNAWYTNGDYLVLIVTMSIIL-PLSLLKNLGYLGYTSGFSLLCMVFF---LIVVIYKK 241

  Fly   236 VQ----------------DLPPVEERESVVWSTLPQFF---SITIFAMEAI-------GVVMPLE 274
            .|                ..||.....:......|::|   |.|::|:..:       ..::|:.
Zfish   242 FQIPCPLPENFINITVNVSQPPQTNNSTDEECCKPKYFIFNSQTVYAVPILTFAFVCHPAILPMY 306

  Fly   275 NNMKTPQSFLGICGVLSQGMSGVTLIYMLLGFLGYLRYGSATGESITLNLPIEEWPAQTVKVLIS 339
            ..:| .:|...:..|.:....|:.::|:|....|||.:..|. |...|:...:.:....|.:::.
Zfish   307 EELK-DRSRRKMQNVANVSFLGMFIMYLLAALFGYLTFNEAV-EPELLHTYSKVYNFDVVLLIVR 369

  Fly   340 LAVYCTFGLQFFVCLEIIWDGIKEKCKKRPTLVNYVL---------RTVLVTAAV-----VLAVA 390
            |||.....|...|.|..|           .|.||::|         |.:.:|.|:     :|.:.
Zfish   370 LAVLTAVTLTVPVVLFPI-----------RTSVNHLLGASKEFSWPRHICITVALLVCVNILVIF 423

  Fly   391 VPTIGPFMGLIGAFCFSILGLIFPVVIELIVHWESGFGKYNWILWKNAIITLCGIGALVF----- 450
            ||||....|.|||...::|..|.|          |.|  |..::.|.::.::..|||.:|
Zfish   424 VPTIRDIFGFIGASAAAMLIFILP----------SAF--YIKLVKKESMKSVQKIGATLFLIMGF 476

  Fly   451 ----GTQA-AIKD-IVKAYSNNENVG 470
                |:.| .|.| |..|.|:.|:.|
Zfish   477 LVMTGSMALIIMDWIHNALSSEEHTG 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
path	NP_001261634.1	SLC5-6-like_sbd	56..456	CDD:294310	100/462 (22%)
path	NP_001261634.1	SdaC	67..445	CDD:223884	94/430 (22%)
slc38a2	NP_001038569.1	Regulates protein turnover upon amino acid deprivation. /evidence=ECO:0000250	1..99		8/28 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		SdaC	70..479	CDD:223884	99/456 (22%)
		SLC5-6-like_sbd	72..488	CDD:294310	100/463 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820