DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment path and slc38a9

DIOPT Version :9

Sequence 1:	NP_001261634.1	Gene:	path / 39106	FlyBaseID:	FBgn0036007	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_001073468.1	Gene:	slc38a9 / 562137	ZFINID:	ZDB-GENE-061013-597	Length:	549	Species:	Danio rerio

Alignment Length:	496	Identity:	90/496 - (18%)
Similarity:	175/496 - (35%)	Gaps:	150/496 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 DNPHPTTDNETLTHLLKASLGTGILGMPFAFMCSGLIMGIFSTIFTAFICTHCSYVLVKCGHKLY 117
            |:|.......|:..:....:||.||.:|:....:|..:||...:....:..:|.|.::|....:.
Zfish   100 DSPIKNPSIVTIFAIWNTMMGTSILSIPWGIKQAGFTLGIIIIVLMGLLTLYCCYRVLKSTKSIP 164

  Fly   118 YRTRRTKMTFAEIAEAAFQKGPKWCRGFAPVAKFSILFGLFLTYFGTCSVYTVIVASNF------ 176
            | ...:...|.::.:..|....||.         |::|.| ::..|...||.|:: |||
Zfish   165 Y-VDTSDWEFPDVCKYYFGGFGKWS---------SLVFSL-VSLIGAMVVYWVLM-SNFLFNTGK 217

  Fly   177 --------------------EQLI----------------------------SYWTGTAVSLRML 193
                                |::|                            .:|.....::...
Zfish   218 FIFNYVHNVNTSDAFGTNGTERVICPYPDVDPHGNSSTSLYSGSDNSTGLEFDHWWSKTNTIPFY 282

  Fly   194 ICIMLVPLI---LIAWVPNLKYLAPVSMVANVFM------GLGLGITFYYLVQDLPPVEERESVV 249
            :.::|:||:   ..::.....:|..:|::..:|:      .||..:.|::....:..|.|..::
Zfish   283 LILLLLPLLNFRSASFFARFTFLGTISVIYLIFLVTYKAIQLGFHLEFHWFDSSMFFVPEFRTL- 346

  Fly   250 WSTLPQFFSITIFAMEAIGVVMPLENNMKTPQSFLGICGVLSQGMSGVTLIYMLLGFLGYLRYG- 313
               .||...:...|......::.|..|.|..::          .:..::|.|:|:| |.||..|
Zfish   347 ---FPQLSGVLTLAFFIHNCIITLMKNNKHQEN----------NVRDLSLAYLLVG-LTYLYVGV 397

  Fly   314 ---------SATGESITLNLPIEEWPAQTVKVLIS--------LAVYCTFGLQFFVCLEII---- 357
                     ..:.|.|..|. ::.:|:..:.|.::        ..||...|  :.|.::::
Zfish   398 LIFAAFPSPPLSKECIEPNF-LDNFPSSDILVFVARTFLLFQMTTVYPLLG--YLVRVQLMGQIF 459

  Fly   358 ---WDGIKEKCKKRPTLVNYVLRTVLVTAAVVLAVAVPTIGPFMGLIGAFCFSILGLIFPVVIEL 419
               :.|.         |..:||...:|.|.|::|...|.||..:...||.|...|..:.|.:|.:
Zfish   460 GNHYPGF---------LHVFVLNVFVVGAGVLMARFYPNIGSIIRYSGALCGLALVFVLPSLIHM 515

  Fly   420 I-------VHWES----GFGKYNWILWKNAIITLCGIGALV 449
            :       :.|.|    ||            :.|.|:..|:
Zfish   516 VSLKRRGELRWTSTLFHGF------------LILLGVANLL 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
path	NP_001261634.1	SLC5-6-like_sbd	56..456	CDD:294310	88/493 (18%)
path	NP_001261634.1	SdaC	67..445	CDD:223884	85/476 (18%)
slc38a9	NP_001073468.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		SdaC	100..549	CDD:223884	90/496 (18%)
		SLC5-6-like_sbd	110..538	CDD:294310	85/478 (18%)
		Important for arginine binding and amino acid transport. /evidence=ECO:0000269\|PubMed:29872228	117..122		1/4 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900