DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment path and SLC38A4

DIOPT Version :9

Sequence 1:	NP_001261634.1	Gene:	path / 39106	FlyBaseID:	FBgn0036007	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_001137296.1	Gene:	SLC38A4 / 55089	HGNCID:	14679	Length:	547	Species:	Homo sapiens

Alignment Length:	492	Identity:	104/492 - (21%)
Similarity:	177/492 - (35%)	Gaps:	135/492 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 DNPHPTTDNETLT--HLLKASLGTGILGMPFAFMCSGLIMGIFSTIFTAFICTHCSYVLVKC--- 112
            |..||.|.:..::  :|..|.:|:||||:.:|...:|:|:.|...:..|.:..:..::|:|.
Human    68 DEHHPGTTSFGMSSFNLSNAIMGSGILGLSYAMANTGIILFIIMLLAVAILSLYSVHLLLKTAKE 132

  Fly   113 GHKLYYRTRRTKMTFAEIAEAAFQKGPKWCRGFAPVAKFSILFGLFLTYFGTCSVYTVIVASNFE 177
            |..|.|.         ::.|.||    .|      ..|......:.:...|..|.|..|:.....
Human   133 GGSLIYE---------KLGEKAF----GW------PGKIGAFVSITMQNIGAMSSYLFIIKYELP 178

  Fly   178 QLIS------------YWTGTAVSLRMLICIMLVPLILIAWVPNLKYLAPVSMVANVFM------ 224
            ::|.            |..|..:.:.:.:.|:| ||.|:..:..|.|.:..|:...||.
Human   179 EVIRAFMGLEENTGEWYLNGNYLIIFVSVGIIL-PLSLLKNLGYLGYTSGFSLTCMVFFVSVVIY 242

  Fly   225 -----------------GLGLGITFYYLVQDLPPVEERESVVW---------------------- 250
                             .|....|....|..||...|...|.:
Human   243 KKFQIPCPLPVLDHSVGNLSFNNTLPMHVVMLPNNSESSDVNFMMDYTHRNPAGLDENQAKGSLH 307

  Fly   251 ------------STLPQFF----------SITIFAMEAIGVVMPLENNMKTPQSFLGICGVLSQG 293
                        ...|::|          .|.:||......|:|:.:.:| .:|...:..|.:..
Human   308 DSGVEYEAHSDDKCEPKYFVFNSRTAYAIPILVFAFVCHPEVLPIYSELK-DRSRRKMQTVSNIS 371

  Fly   294 MSGVTLIYMLLGFLGYLR-YGSATGESI-------TLNLPIEEWPAQTVKVLISLAVYCTFGLQF 350
            ::|:.::|:|....|||. ||....|.:       ||::|:     ..|::.:.:||..|..:..
Human   372 ITGMLVMYLLAALFGYLTFYGEVEDELLHAYSKVYTLDIPL-----LMVRLAVLVAVTLTVPIVL 431

  Fly   351 FVCLEIIWDGIKEKCKKRP--TLVNYVLRTVLVTAAVVLAVAVPTIGPFMGLIGAFCFSILGLIF 413
            |   .|....|.....|||  .:.::::..||:....||.:.||||....|.|||...::|..|.
Human   432 F---PIRTSVITLLFPKRPFSWIRHFLIAAVLIALNNVLVILVPTIKYIFGFIGASSATMLIFIL 493

  Fly   414 PVVIELIVHWESGFGKYNWILWKNAIITLCGIGALVF 450
            |.|.            |..::.|....:...:|||:|
Human   494 PAVF------------YLKLVKKETFRSPQKVGALIF 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
path	NP_001261634.1	SLC5-6-like_sbd	56..456	CDD:294310	103/489 (21%)
path	NP_001261634.1	SdaC	67..445	CDD:223884	96/469 (20%)
SLC38A4	NP_001137296.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		SdaC	71..534	CDD:223884	103/489 (21%)
		SLC5-6-like_sbd	73..535	CDD:294310	101/487 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820