Protein Alignment path and SLC38A2

DIOPT Version :9

• Sequence 1: NP_001261634.1
• Gene: path / 39106
• FlyBaseID: FBgn0036007
• Length: 471
• Species: Drosophila melanogaster
• Sequence 2: NP_061849.2
• Gene: SLC38A2 / 54407
• HGNCID: 13448
• Length: 506
• Species: Homo sapiens
• Alignment Length: 545
• Identity: 122/545 - (22%)
• Similarity: 186/545 - (34%)
• Gaps: 180/545 - (33%)

  Fly    15 EMEQF--LPGEGKVMYKIQPRKSD------TEQALAGN---DFDP----FALRDN---------- 54
            ||.:|  .|.|....|.   ..||      |:||...:   |.||    |.|..|
Human     5 EMGRFSISPDEDSSSYS---SNSDFNYSYPTKQAALKSHYADVDPENQNFLLESNLGKKKYETEF 66

  Fly    55 -PHPTTDNETLTHLLKASLGTGILGMPFAFMCSGLIMGIFSTIFTAFICTHCSYVLVKC---GHK 115
             |..|:...::.:|..|.:|:||||:.:|...:|:.:.|....|.:....:..::|:|.   |..
Human    67 HPGTTSFGMSVFNLSNAIVGSGILGLSYAMANTGIALFIILLTFVSIFSLYSVHLLLKTANEGGS 131

  Fly   116 LYYRTRRTKMTFAEIAEAAFQKGPKWCRGFAPVAKFSILFGLFLTYFGTCSVYTVIV-------- 172
            |.|.                |.|.|   .|..|.|.:....:.:...|..|.|..||
Human   132 LLYE----------------QLGYK---AFGLVGKLAASGSITMQNIGAMSSYLFIVKYELPLVI 177

  Fly   173 --ASNFEQLISYWTGTAVSLRMLI-CIMLVPLILIAWVPNLKYLAPVSMVANVFMGLGLGITFYY 234
              .:|.|.....|......|.:|: .::::||.|..   ||.||...|       ||.|....::
Human   178 QALTNIEDKTGLWYLNGNYLVLLVSLVVILPLSLFR---NLGYLGYTS-------GLSLLCMVFF 232

  Fly   235 LVQ------DLP-PVEER---ESVVWSTL---------------------PQFF----------S 258
            |:.      .:| |||..   ...:.:||                     |.:|          .
Human   233 LIVVICKKFQVPCPVEAALIINETINTTLTQPTALVPALSHNVTENDSCRPHYFIFNSQTVYAVP 297

  Fly   259 ITIFAMEAIGVVMPLENNMKTPQSFLGICGVLSQGMSGVTLIYMLLGFLGYL------------R 311
            |.||:......|:|:...:| .:|...:..|.......:.|:|:|....|||            .
Human   298 ILIFSFVCHPAVLPIYEELK-DRSRRRMMNVSKISFFAMFLMYLLAALFGYLTFYEHVESELLHT 361

  Fly   312 YGSATGESITLNLPIEEWPAQTVKVLISLAVYCTFGLQFF---------VCL--EIIWDGIKEKC 365
            |.|..|..|.|.:         |::.:.:||..|..:..|         :|.  :..|
Human   362 YSSILGTDILLLI---------VRLAVLMAVTLTVPVVIFPIRSSVTHLLCASKDFSW------- 410

  Fly   366 KKRPTLVNYVLRTVLVTAAV-----VLAVAVPTIGPFMGLIGAFCFSILGLIFPVVIELIVHWES 425
                      .|..|:|.::     :|.:.||||....|.|||...|:|..|.|          |
Human   411 ----------WRHSLITVSILAFTNLLVIFVPTIRDIFGFIGASAASMLIFILP----------S 455

  Fly   426 GFGKYNWILWKNAIITLCGIGALVF 450
            .|  |..::.|..:.::..||||.|
Human   456 AF--YIKLVKKEPMKSVQKIGALFF 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
path	NP_001261634.1	SLC5-6-like_sbd	56..456	CDD:294310	104/478 (22%)
		SdaC	67..445	CDD:223884	98/460 (21%)
SLC38A2	NP_061849.2	Regulates protein turnover upon amino acid deprivation. /evidence=ECO:0000250	1..96		26/93 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		6/20 (30%)
		SLC5-6-like_sbd	69..495	CDD:320982	104/478 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820