DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment path and Slc36a4

DIOPT Version :9

Sequence 1:	NP_001261634.1	Gene:	path / 39106	FlyBaseID:	FBgn0036007	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_001101597.1	Gene:	Slc36a4 / 315439	RGDID:	1311528	Length:	500	Species:	Rattus norvegicus

Alignment Length:	436	Identity:	141/436 - (32%)
Similarity:	223/436 - (51%)	Gaps:	41/436 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 DNPHPTTDNETLTHLLKASLGTGILGMPFAFMCSGLIMGIFSTIFTAFICTHCSYVLVKCGHKLY 117
            |..|..:..:||.||||.::|||:||:|.|...:|:::|..|.:|...|..||.::||:|.|.|.
  Rat    51 DGQHGISFVQTLMHLLKGNIGTGLLGLPLAIKNAGIVLGPISLVFIGIISVHCMHILVRCSHFLC 115

  Fly   118 YRTRRTKMTFAEIAEAAFQKGPKWC-RGFAPVAKFSILFGLFLTYFGTCSVY------------- 168
            .|.:::.:.:::....|.:..|..| :..|...:..:.|.|.:|..|.||||
  Rat   116 QRFKKSTLGYSDTVSFAMEASPWSCLQRQAAWGRSVVDFFLVITQLGFCSVYIVFLAENVKQVHE 180

  Fly   169 ----TVIVASNFEQLISYWTGTAVSLRMLICIMLVPLILIAWVPNLKYLAPVSMVANVFMGLGLG 229
                |.:|.||...|.......:|.||:.:...|..|||:.::..||.|..:|.:||:.|...|.
  Rat   181 GLLETTVVVSNSSDLSQVCERRSVDLRVYMLCFLPLLILLVFIRELKSLFVLSFLANISMAASLV 245

  Fly   230 ITFYYLVQDLPPVEERESVV-WSTLPQFFSITIFAMEAIGVVMPLENNMKTPQSFLGICGVLSQG 293
            |.:.|:|:.:|.......|. |...|.||...:||.|.||||:||||.|:..:.|   ...|:.|
  Rat   246 IIYQYVVRSMPDPHNLPIVAGWKKYPLFFGTAVFAFEGIGVVLPLENQMRESKRF---PQALNIG 307

  Fly   294 MSGVTLIYMLLGFLGYLRYGSATGESITLNLPIEEWPAQTVKVLISLAVYCTFGLQFFVCLEIIW 358
            |:.||::|:.|..|||:.:......|||||||.:.|..|:||:|.|..::.|:.:||:|..|||.
  Rat   308 MAIVTVLYISLATLGYMCFRDEIKGSITLNLPQDMWLYQSVKILYSFGIFVTYSIQFYVPAEIII 372

  Fly   359 DGI------KEKCKKRPTLVNYVLRTVLVTAAVVLAVAVPTIGPFMGLIGAFCFSILGLIFPVVI 417
            ..:      |.||     :.::.:|::||:.....||.:|.:...:..:||...|.|.||.|.::
  Rat   373 PAVTARLHAKWKC-----ICDFGIRSLLVSITCAGAVLIPRLDIVISFVGAVSSSTLALILPPLV 432

  Fly   418 ELIVHWESGFGK--YN-WILWKNAIITLCGIGALVFGTQAAIKDIV 460
            |::.     |.|  || |::.||..|...|....:.||...:::|:
  Rat   433 EILT-----FSKDHYNVWMVLKNISIAFTGFVGFLLGTYVTVEEII 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
path	NP_001261634.1	SLC5-6-like_sbd	56..456	CDD:294310	139/427 (33%)
path	NP_001261634.1	SdaC	67..445	CDD:223884	132/405 (33%)
Slc36a4	NP_001101597.1	SLC5-6-like_sbd	54..469	CDD:294310	139/427 (33%)
Slc36a4	NP_001101597.1	PotE	<223..477	CDD:223605	89/264 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	1	1.010	-	-		D284074at33208
OrthoFinder	1	1.000	-	-		FOG0000138
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22950
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X121
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.930