Protein Alignment path and SLC36A3

DIOPT Version :10

• Sequence 1: NP_648327.1
• Gene: path / 39106
• FlyBaseID: FBgn0036007
• Length: 471
• Species: Drosophila melanogaster
• Sequence 2: NP_001138489.1
• Gene: SLC36A3 / 285641
• HGNCID: 19659
• Length: 511
• Species: Homo sapiens
• Alignment Length: 477
• Identity: 139/477 - (29%)
• Similarity: 234/477 - (49%)
• Gaps: 69/477 - (14%)

  Fly    53 DNPHPTTD-----NETLTHLLKASLGTGILGMPFAFMCSGLIMGIFSTIFTAFICTHCSYVLVKC 112
            :|.||..:     .:||.||||.::|||:||:|.|...:||::|..|.:....:..||..:|:.|
Human    32 ENVHPAGEAGLSMMQTLIHLLKCNIGTGLLGLPLAIKNAGLLVGPVSLLAIGVLTVHCMVILLNC 96

  Fly   113 GHKLYYRTRRTKMTFAEIAEAAFQKGP-----------KW---------CRG------------- 144
            ...|..|.::|.:.:.|......:..|           :|         |.|
Human    97 AQHLSQRLQKTFVNYGEATMYGLETCPNTWLRAHAVWGRWNLALSPRLECSGKISAHCNPHLQGS 161

  Fly   145 ---------FAPVAKFSILFGLFLTYFGTCSVYTVIVASNFEQLISYWTGTA------------- 187
                     .|.:.::::.|.|.:|..|.||||.:.:|.|.:|::.....|:
Human   162 SNSPAQASRVAGIYRYTVSFLLVITQLGFCSVYFMFMADNLQQMVEKAHVTSNICQPREILTLTP 226

  Fly   188 -VSLRMLICIMLVPLILIAWVPNLKYLAPVSMVANVFMGLGLGITFYYLVQDLP-PVEERESVVW 250
             :.:|..:.|:|..|||:.::.|||.|:..|.:||:.....:.:.|.|:::.:| |........|
Human   227 ILDIRFYMLIILPFLILLVFIQNLKVLSVFSTLANITTLGSMALIFEYIMEGIPYPSNLPLMANW 291

  Fly   251 STLPQFFSITIFAMEAIGVVMPLENNMKTPQSFLGICGVLSQGMSGVTLIYMLLGFLGYLRYGSA 315
            .|...||...||..|.:|:|:||:|.||.||.|   ..||..|||.|.::|:|||.|||:::||.
Human   292 KTFLLFFGTAIFTFEGVGMVLPLKNQMKHPQQF---SFVLYLGMSIVIILYILLGTLGYMKFGSD 353

  Fly   316 TGESITLNLPIEEWPAQTVKVLISLAVYCTFGLQFFVCLEIIWD-GIKEKCKKRPTLVNYVLRTV 379
            |..||||||| ..|..|:||::.|:.::.|:.|||.|..|||.. .|.:..:.....|:..:|:.
Human   354 TQASITLNLP-NCWLYQSVKLMYSIGIFFTYALQFHVPAEIIIPFAISQVSESWALFVDLSVRSA 417

  Fly   380 LVTAAVVLAVAVPTIGPFMGLIGAFCFSILGLIFPVVIELIVHWESGFGKYNWILWKNAIITLCG 444
            ||....|.|:.:|.:...:.|:|:...|.|.||.|.::|:::.:........  :.|:.:|::.|
Human   418 LVCLTCVSAILIPRLDLVISLVGSVSSSALALIIPALLEIVIFYSEDMSCVT--IAKDIMISIVG 480

  Fly   445 IGALVFGTQAAIKDIVKAYSNN 466
            :...:|||..|:.::.:..|::
Human   481 LLGCIFGTYQALYELPQPISHS 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
path	NP_648327.1	SLC5-6-like_sbd	56..456	CDD:444915	136/462 (29%)
SLC36A3	NP_001138489.1	SLC5-6-like_sbd	41..492	CDD:444915	134/456 (29%)