DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment path and slc-36.5

DIOPT Version :9

Sequence 1:	NP_001261634.1	Gene:	path / 39106	FlyBaseID:	FBgn0036007	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_001022026.1	Gene:	slc-36.5 / 174125	WormBaseID:	WBGene00016628	Length:	489	Species:	Caenorhabditis elegans

Alignment Length:	479	Identity:	122/479 - (25%)
Similarity:	221/479 - (46%)	Gaps:	42/479 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVNIVDSGSKHAPQEMEQFLPGEGKVMYKIQPRKSDTEQALAGNDFDPFALRDNPHPTTDNETLT 65
            |:::.|.|..:...|            |::..:..:.|:||.......|.  :.....:....|.
Worm    33 MLDLHDIGMHNVQSE------------YQLVSKWDEAEEALGPQRKMSFI--ERKEKISSKFALI 83

  Fly    66 HLLKASLGTGILGMPFAFMCSGLIMGIFSTIFTAFICTHCSYVLVKCGHKLYYRTRRTKMTFAEI 130
            :|:|..||.|...:|.||..||.:.|:...:...|:|..|...||||...|....:...:.:..:
Worm    84 NLMKGMLGAGCFSVPLAFKQSGYVSGLVIIVVLGFLCALCMIKLVKCAGYLSKVNQSAPLDYGNM 148

  Fly   131 AEAAFQKGPKWCRGFAPVAKFSILFGLFLTYFGTCSVYTVIVASNFEQLISYWTGTAVSLRMLIC 195
            |..|.|......|..|||::..:...|.:...|.|..:.:.|..:..:|:.:......|...|..
Worm   149 AYKATQASYTPIRKLAPVSRALVNSSLCILQLGICCCFYIFVVYHLHELLEFVMNDVPSRATLFP 213

  Fly   196 IMLVPLILIAWVPNLKYLAPVSMVANVFMGLGLGITFYYL-------VQDLPPVEERESVVWSTL 253
            ::|...||:..:.:::.|:.||:..|..|.:.|.:..:.|       :.|||||.:...:|.:.
Worm   214 MVLPAFILLVSLSSMRALSLVSLGGNFLMLIALAVIMFQLLTTEHKKLADLPPVTDLMGIVSAA- 277

  Fly   254 PQFFSITIFAMEAIGVVMPLENNMKTPQSFLGICGVLSQGMSGVTLIYMLLGFLGYLRYGSATGE 318
                ...::|:|...:|:||||.||.|:...|..||||.|:..|.:||...||.|:|.||:...:
Worm   278 ----GTILYALEGQAMVLPLENRMKKPEDMKGPFGVLSVGVGMVVVIYSFAGFFGFLTYGNDVQD 338

  Fly   319 SITLNLPIEEWPAQTVKVLISLAVYCTFGLQFFVCLEIIWDGIKEKCK---------KRPTLVNY 374
            ||||||| .:.....||.::...||..|.:|.|..:.:||..||:|.:         ||  :|::
Worm   339 SITLNLP-NDHLGIFVKAVLLFVVYSGFLIQVFPIVAMIWPAIKKKLRTTCGVSTTTKR--IVHF 400

  Fly   375 VLRTVLVTAAVVLAVAVPTIGPFMGLIGAFCFSILGLIFPVVIELIV---HWESGFGKYNWILWK 436
            ..|..:|....:|:.|:|.:...:.|:|.....:|.|:||.:..|::   .:|...| :.:.::.
Worm   401 AFRYSIVIVVFLLSYAIPRLSDMVPLVGVTAGMLLALVFPSLFHLLIFLPQFECRIG-FLFDIFL 464

  Fly   437 NAIITLCGIGALVFGTQAAIKDIV 460
            :.:..:.|:..:::|:...::.::
Worm   465 DFVCIILGMFFVIYGSITHVQHLM 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
path	NP_001261634.1	SLC5-6-like_sbd	56..456	CDD:294310	113/418 (27%)
path	NP_001261634.1	SdaC	67..445	CDD:223884	110/396 (28%)
slc-36.5	NP_001022026.1	SLC5-6-like_sbd	75..481	CDD:382020	113/414 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	1	1.010	-	-		D284074at33208
OrthoFinder	1	1.000	-	-		FOG0000138
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22950
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X121
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.030