Protein Alignment path and SLC36A2

DIOPT Version :10

• Sequence 1: NP_648327.1
• Gene: path / 39106
• FlyBaseID: FBgn0036007
• Length: 471
• Species: Drosophila melanogaster
• Sequence 2: NP_861441.2
• Gene: SLC36A2 / 153201
• HGNCID: 18762
• Length: 483
• Species: Homo sapiens
• Alignment Length: 475
• Identity: 150/475 - (31%)
• Similarity: 237/475 - (49%)
• Gaps: 38/475 - (8%)

  Fly    23 EGKVMYKIQPRKSDTEQALAGNDFDPFALRDNPHPT---------TDNETLTHLLKASLGTGILG 78
            :|.|..|:. ..|..|.|....:.|...|.::|..:         |..:.|.||:|.::||||||
Human    11 QGAVAIKLD-LMSPPESAKKLENKDSTFLDESPSESAGLKKTKGITVFQALIHLVKGNMGTGILG 74

  Fly    79 MPFAFMCSGLIMGIFSTIFTAFICTHCSYVLVKCGHKLYYRTRRTKMTFAEIAEAAFQKGPK-WC 142
            :|.|...:|::||..|.:...||..||.::||||..:...|..:..|.:.:......:..|. |.
Human    75 LPLAVKNAGILMGPLSLLVMGFIACHCMHILVKCAQRFCKRLNKPFMDYGDTVMHGLEANPNAWL 139

  Fly   143 RGFAPVAKFSILFGLFLTYFGTCSVYTVIVASNFEQLISYWTGTAVSLRMLICIMLVP------- 200
            :..|...:..:.|.|.:|..|.|.||.|.:|.|.:|::.....|..:......::|.|
Human   140 QNHAHWGRHIVSFFLIITQLGFCCVYIVFLADNLKQVVEAVNSTTNNCYSNETVILTPTMDSRLY 204

  Fly   201 -------LILIAWVPNLKYLAPVSMVANVFMGLGLGITFYYLVQDLPPVEERESVV-WSTLPQFF 257
                   |:|:..:.||:.|...||:||:.|.:.|.|...|:.|::|.......|. |.|.|.||
Human   205 MLSFLPFLVLLVLIRNLRILTIFSMLANISMLVSLVIIIQYITQEIPDPSRLPLVASWKTYPLFF 269

  Fly   258 SITIFAMEAIGVVMPLENNMKTPQSFLGICGVLSQGMSGVTLIYMLLGFLGYLRYGSATGESITL 322
            ...||:.|:||||:||||.||..:.|..|   ||.|||.||.:|:.:..|||||:|.....||:|
Human   270 GTAIFSFESIGVVLPLENKMKNARHFPAI---LSLGMSIVTSLYIGMAALGYLRFGDDIKASISL 331

  Fly   323 NLPIEEWPAQTVKVLISLAVYCTFGLQFFVCLEIIWDGIKEKCKKRPTL-VNYVLRTVLVTAAVV 386
            ||| ..|..|:||:|....:.||:.|||:|..|||......:...|..| ::..:|.|:|....:
Human   332 NLP-NCWLYQSVKLLYIAGILCTYALQFYVPAEIIIPFAISRVSTRWALPLDLSIRLVMVCLTCL 395

  Fly   387 LAVAVPTIGPFMGLIGAFCFSILGLIFPVVIELIVHWESGFGKYNWILWKNAIITLCGIGALVFG 451
            ||:.:|.:...:.|:|:...:.|.||.|.::|:...:..|.....  ::|:|:|::.|....|.|
Human   396 LAILIPRLDLVISLVGSVSGTALALIIPPLLEVTTFYSEGMSPLT--IFKDALISILGFVGFVVG 458

  Fly   452 TQAAIKDIVKA-----YSNN 466
            |..|:.:::|:     :||:
Human   459 TYQALDELLKSEDSHPFSNS 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
path	NP_648327.1	SLC5-6-like_sbd	56..456	CDD:444915	137/425 (32%)
SLC36A2	NP_861441.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	26..46		4/19 (21%)
		SLC5-6-like_sbd	52..463	CDD:444915	137/416 (33%)