DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment path and slc36a4

DIOPT Version :9

Sequence 1:	NP_001261634.1	Gene:	path / 39106	FlyBaseID:	FBgn0036007	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	XP_002940192.3	Gene:	slc36a4 / 100493349	XenbaseID:	XB-GENE-994062	Length:	523	Species:	Xenopus tropicalis

Alignment Length:	505	Identity:	153/505 - (30%)
Similarity:	248/505 - (49%)	Gaps:	57/505 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VNIVDSGSKHAPQEMEQFLPGE----GKVMYK------IQPRKSDTEQALA------GNDFDPFA 50
            :.:...|.:...:.|:..:..|    ||...|      :|..:|.|::.:.      .:|.|.|.
Frog     4 LGVSGEGEEIGMEVMKPLIKNEDSFDGKYAEKKYSQRHLQHAESRTDKEVMKPLIENEDDSDGFG 68

  Fly    51 -----LRDNPHPTTDN-----ETLTHLLKASLGTGILGMPFAFMCSGLIMGIFSTIFTAFICTHC 105
                 |:...|..:.:     :||.||||.::|||:||:|.|...:||::|..|.:|...|..||
Frog    69 DEHQYLQRRQHSDSKDGLTFFQTLIHLLKGNIGTGLLGLPLAIKNAGLLLGPISLLFFGIISIHC 133

  Fly   106 SYVLVKCGHKLYYRTRRTKMTFAEIAEAAFQKGPKWCRGF----APVAKFSILFGLFLTYFGTCS 166
            ..:||:|.|.|..|.::..:.::|....|.:.||.   ||    |...:..:.:.|.:|..|.||
Frog   134 MNILVRCSHFLCQRYKKANLGYSETVGLALEVGPS---GFLQRRASFGRSMVDWFLVVTQLGFCS 195

  Fly   167 VYTVIVASNFEQLISYWTGT-----------AVSLRMLICIMLVPLILIAWVPNLKYLAPVSMVA 220
            ||.|.:|.|.:|::..:..|           .:.||:.:...|..:|.:.::.:||.|:.:|.:|
Frog   196 VYFVFLAENIKQVLEVFLATKLQQPGIGGIWTLDLRIYMFSFLPLIIPLVFIRDLKNLSLLSFLA 260

  Fly   221 NVFMGLGLGITFYYLVQDL-PPVEERESVVWSTLPQFFSITIFAMEAIGVVMPLENNMKTPQSFL 284
            |:.|.:.|.|.:.|::::| .|........|.|.|.||...|||.|.||||:||||.|:..:.|
Frog   261 NLSMAISLIIVYQYVIRNLSDPRALPLGTSWKTYPLFFGTAIFAFEGIGVVLPLENRMRDKKDF- 324

  Fly   285 GICGVLSQGMSGVTLIYMLLGFLGYLRYGSATGESITLNLPIEEWPAQTVKVLISLAVYCTFGLQ 349
              ...|:.||:.||.:|:.|..|||..:|.....|||||||.:.|..|.||:|.|..:|.|:.:|
Frog   325 --SKALNIGMAIVTALYISLATLGYFCFGDQIKGSITLNLPQDSWLYQVVKILYSFGIYVTYAIQ 387

  Fly   350 FFVCLEIIWDGIKEKCKK-RPTLVNYVLRTVLVTAAVVLAVAVPTIGPFMGLIGAFCFSILGLIF 413
            ::|..|||...:..:.:| |..|..:.:|..||......||.:|.:...:..:||...|.|.||.
Frog   388 YYVPAEIILPAVTSRVQKTRKLLCEFTMRFFLVCLTCAFAVLIPRLDLVISFVGAVSSSTLALIL 452

  Fly   414 PVVIELIVHWESGFGKYN---WILWKNAIITLCGIGALVFGTQAAIKDIV 460
            |.::|:|.     |.|.:   |::.|:..|...|....:.||...|::::
Frog   453 PPLVEIIT-----FQKEHLSPWVIAKDIAIAAIGFVGFLAGTYVTIEEMI 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
path	NP_001261634.1	SLC5-6-like_sbd	56..456	CDD:294310	139/424 (33%)
path	NP_001261634.1	SdaC	67..445	CDD:223884	132/397 (33%)
slc36a4	XP_002940192.3	SLC5-6-like_sbd	84..493	CDD:382020	138/419 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	1	1.010	-	-		D284074at33208
OrthoFinder	1	1.000	-	-		FOG0000138
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22950
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X121
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.030