DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pall and FBXO28

DIOPT Version :9

Sequence 1:	NP_648325.2	Gene:	pall / 39104	FlyBaseID:	FBgn0036005	Length:	314	Species:	Drosophila melanogaster
Sequence 2:	NP_055991.1	Gene:	FBXO28 / 23219	HGNCID:	29046	Length:	368	Species:	Homo sapiens

Alignment Length:	329	Identity:	116/329 - (35%)
Similarity:	184/329 - (55%)	Gaps:	48/329 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLDLPQTLIQDILELLPYDEVAKKREVCTLFNYLGQQILNKGFNKIIMAHAKNFKRIKSMLPRRE 67
            |:.||...|::||..:.|||:::.|.||...:.:.|::||:||.|:...|....|::|:.|||||
Human    64 LVALPIVAIENILSFMSYDEISQLRLVCKRMDLVCQRMLNQGFLKVERYHNLCQKQVKAQLPRRE 128

  Fly    68 SERRNHILSRHSDILTSIETRISMLTMTYSKFIDLNICCFIPGRVLDEINSILRILSTSTKQLRP 132
            ||||||.|:||:|||.::|||:|:|.||:.|::|.|:||||||:|:|||..:||.::::....|.
Human   129 SERRNHSLARHADILAAVETRLSLLNMTFMKYVDSNLCCFIPGKVIDEIYRVLRYVNSTRAPQRA 193

  Fly   133 HEVLQELRDISSMAIEHFDEKIAVNFKLEHRKQLAESTAAGARLVVCSALGDISFSGVRRTGISR 197
            ||||||||||||||:|:|||||....|    ::|..|..:|                 |..| |.
Human   194 HEVLQELRDISSMAMEYFDEKIVPILK----RKLPGSDVSG-----------------RLMG-SP 236

  Fly   198 PVDHGLVQQAIVQLAPISASKSHSDSSQKDRMSKQLFKQ----YQLQRSLSQ---KIRLLEVSRK 255
            ||.........:||    .||.:....:..::.:|:...    ..|:|.:|:   |::..:...:
Human   237 PVPGPSAALTTMQL----FSKQNPSRQEVTKLQQQVKTNGAGVTVLRREISELRTKVQEQQKQLQ 297

  Fly   256 VQDRRLQEALSSITELTTQVSELKRQMEDVV-----------ANMPSCAVKRQAVASADCLPPAL 309
            .||::|.|....|.|...:::||:|::.:|:           .|..|...:::|..:.|    :|
Human   298 DQDQKLLEQTQIIGEQNARLAELERKLREVMESAVGNSSGSGQNEESPRKRKKATEAID----SL 358

  Fly   310 KKPK 313
            :|.|
Human   359 RKSK 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pall	NP_648325.2	None
FBXO28	NP_055991.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..56
		F-box	67..108	CDD:366220	16/40 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..368		7/39 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152968
Domainoid	1	1.000	153	1.000	Domainoid score	I4315
eggNOG	1	0.900	-	-		E1_28KQY
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	175	1.000	Inparanoid score	I4065
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D346120at33208
OrthoFinder	1	1.000	-	-		FOG0008425
OrthoInspector	1	1.000	-	-		oto90035
orthoMCL	1	0.900	-	-		OOG6_110167
Panther	1	1.100	-	-	LDO	PTHR13252
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5631
SonicParanoid	1	1.000	-	-		X6415
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790