DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jarid2 and JHD2

DIOPT Version :9

Sequence 1:	NP_648324.1	Gene:	Jarid2 / 39103	FlyBaseID:	FBgn0036004	Length:	2351	Species:	Drosophila melanogaster
Sequence 2:	NP_012653.1	Gene:	JHD2 / 853583	SGDID:	S000003880	Length:	728	Species:	Saccharomyces cerevisiae

Alignment Length:	784	Identity:	171/784 - (21%)
Similarity:	279/784 - (35%)	Gaps:	235/784 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1738 MVEAPIFRPTEKEFADPIEFIE--RITPIAARFGICKIIPPASFKPECRISDEMRFTAYNQ---- 1796
            |.|.|...|||:||.:||:::.  .|..:..|:|:.|::||..|.|...| |...||...:
Yeast     1 MEEIPALYPTEQEFKNPIDYLSNPHIKRLGVRYGMVKVVPPNGFCPPLSI-DMENFTFQPRIQNL 64

  Fly  1797 -----------YVHKMLHRWGPSAKELSAIKKYLATQSIVMNHPPWIGGMEVDLPRLYHTVQELG 1850
                       :..|.|:.:..|.|:.|         .:::..|              :|:.|..
Yeast    65 ENLDLKNRCRLFFMKQLNNFKRSVKDPS---------KLILREP--------------YTIVEYS 106

  Fly  1851 G---LKEVIEKK-----------------------------------------KWARVAEEMCIP 1871
            .   ..|:::||                                         .|..::::..:|
Yeast   107 DSTHASEILKKKVYFYDVFSELIKDNRTLTDTTQSFRRKLKFRDISQLRGDISLWRTISKKFNVP 171

  Fly  1872 KLAQDRVTKLDDIYCKYLLPYDTLSPAERQKLFDEVEADWAKREARARRNADRFVNTESVSNEED 1936
                  :..|.:|:.||:..|.....:..:.:...:.||...:...:....|..:..:  ||...
Yeast   172 ------IGLLKEIFEKYIASYYIFLHSLNENVHTALHADQYPKSLLSDDEDDFDLGPD--SNSGS 228

  Fly  1937 DLSSDEDE---------------------------------ESEEEIDGVSMECIV--------- 1959
            |...|:|:                                 |.....|.:...|||
Yeast   229 DFEEDDDDACIVCRKTNDPKRTILCDSCDKPFHIYCLSPPLERVPSGDWICNTCIVGNGYYGFTQ 293

  Fly  1960 --KGRSMPLSQFYRIARNTMALWFKSTDPTVNEVEAEFWRHVAV--RDSHVCVHSGS---IDSSG 2017
              ...|:|..|.|...:|:..|  .:...:::|:|..||..|..  |.|...|..|:   .:..|
Yeast   294 DTHDYSLPEFQEYCKRQNSRLL--PARKLSIDELEEMFWSLVTKNRRSSLTTVKYGADIHNELPG 356

  Fly  2018 WGYGFPSPG--PKGKGSN-------YARHPWNLKVLTNNSGSVL----RSLGPVMGVTVPTLHVG 2069
            ...|||:..  ||....:       |..||.||..|.....|:|    |:   :.|:|:|.:::|
Yeast   357 QITGFPTREFIPKNINGDELIDYLKYCDHPMNLTNLPMAHNSLLPLFKRN---ISGMTIPWIYIG 418

  Fly  2070 MLFSACCWY-RDPHGLSWIEYLHTGASKLWYGIPDDQSANFRAALTSLIP---------THCQNK 2124
            .|||..||: .|.:.|| ..|.|.|..|:||.||:.....|...|..:.|         .| |..
Yeast   419 SLFSTFCWHMEDQYTLS-ANYQHEGDPKVWYSIPESGCTKFNDLLNDMSPDLFIKQPDLLH-QLV 481

  Fly  2125 TIWLPCDTVMVPPHMLTDRGVSLCRIEQKPGEFIVVFPRAYTSSLATGYVVSESVYFATMSWLDL 2189
            |:..|.|     |: ....|:.:.:..|||.|:|:.||:.|.:...|||..:|:|.|....||..
Yeast   482 TLISPYD-----PN-FKKSGIPVYKAVQKPNEYIITFPKCYHAGFNTGYNFNEAVNFTIDFWLPY 540

  Fly  2190 ---AKDDFRDIHESCEPAMFSL----------EQLLFALGYDQRVNSEALHQMLPMLNDVCEKES 2241
               |..|::...::|...||.|          :.|||        |...:.|....|......|.
Yeast   541 GFGAITDYKLTQKACVFDMFDLMINVLDKYNKDTLLF--------NDAFVRQCYSSLIVFYNTEL 597

  Fly  2242 AAREQLRAAGVTSTEKVQAEKGQKAKKQQQPPYKSIESEC-DLC------RANLYISM------- 2292
            ....:::|. |..|..::.......:.::   |....|:| .:|      |.|.|.|:
Yeast   598 KRIRKIQAI-VPRTTLLEVHTDPNDEDEE---YDIFCSQCKTICSIAFVLRKNNYDSIRTYKRHK 658

  Fly  2293 -----------VRTEDG--NIYCLQHALK---NLNNGNIQAKQC--KLIYAYNVDDIQQLIRQLQ 2339
                       :.|.|.  :|.|.|..||   ||||.:.:....  :|.:..::.||..||:|:.
Yeast   659 KNHLSIRQWNELSTTDSKVSILCTQDYLKSIQNLNNSDGEEPYIDDELYFTKSLKDIDSLIKQVG 723

  Fly  2340 EKIN 2343
            .|::
Yeast   724 VKLD 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jarid2	NP_648324.1	JmjN	1740..1781	CDD:128818	16/42 (38%)
		ARID	1812..1893	CDD:279697	13/124 (10%)
		JmjC	2066..2181	CDD:202224	40/124 (32%)
		zf-C5HC2	2281..2334	CDD:280996	20/84 (24%)
JHD2	NP_012653.1	JmjN	3..46	CDD:128818	16/42 (38%)
		PHD_BAZ1A_like	237..282	CDD:277019	2/44 (5%)
		BAH	260..>320	CDD:413397	11/61 (18%)
		JmjC	414..532	CDD:396791	40/125 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10694
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910