DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jarid2 and kdm5c

DIOPT Version :9

Sequence 1:	NP_648324.1	Gene:	Jarid2 / 39103	FlyBaseID:	FBgn0036004	Length:	2351	Species:	Drosophila melanogaster
Sequence 2:	NP_001072719.1	Gene:	kdm5c / 780176	XenbaseID:	XB-GENE-1033025	Length:	1506	Species:	Xenopus tropicalis

Alignment Length:	818	Identity:	193/818 - (23%)
Similarity:	300/818 - (36%)	Gaps:	247/818 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1733 DDPTQMVEAPIFRPTEKEFADPIEFIERITPIAARFGICKIIPPASFKPECRIS-DEMRFTAYNQ 1796
            :|.....|.|:|.||.:||.||:.:|.:|.|||.:.|||||.||..::|...:. |...||...|
Frog     7 EDFVPPAECPVFEPTWEEFKDPLGYIAKIRPIAEKSGICKIRPPVDWQPPFAVEVDNFHFTPRIQ 71

  Fly  1797 YVHKMLHRWGPSAKELSAIKKYLATQSIVMNHPPWIGGME---VDLPRLYHTVQELGGLKEVIEK 1858
            .::::..........|..|.|:...|...:..|    .:|   :||..|...|||.||.:.:..:
Frog    72 RLNELEAETRVKLNYLDQIAKFWEIQGSSLKIP----NVERRILDLYSLNKIVQEEGGYEPICRE 132

  Fly  1859 KKWARVAEEMCIPKLAQDRVTKLDDIYCKYLLPY-------DTLSPAERQKLFDEVEAD------ 1910
            ::|||||:.|..|. .::..:.|...|.:.:.|:       :.:...||.: :|..|.|
Frog   133 RRWARVAQRMGYPS-GKNLGSLLRSHYERIIYPFHMYQSGANMVDYRERPR-YDNEEKDKEYKPH 195

  Fly  1911 ---------------WAKREARARR----NADRFVNTESVSNEEDDLSSD---EDEESEEEI--- 1950
                           :.:|..|..:    |:|....:.|...|......:   ||.|...|:
Frog   196 SIPLRQSVQPSKITSYGRRAKRLTQEDPENSDPAAQSSSQPTETSPSWPEPTVEDIEKNPELKKL 260

  Fly  1951 ------------------------DGVSMEC----------IVKGRSMP---------------- 1965
                                    |....||          .|:||..|
Frog   261 QIYGAGPKMMGLGLMAKNKNLRKKDSDIPECPPTLVIKEEVPVEGRGEPGEVQVHVKQERSLSPE 325

  Fly  1966 --LSQFYRIARNTM------------------------------------------------ALW 1980
              .....|:.|||:                                                .:|
Frog   326 PCTKMTMRLRRNTITNSNQFVDSYICRICSRGDDDDRLLLCDGCDDNYHTFCLLPPLPEPPKGIW 390

  Fly  1981 -------------------------------------FKS--------TDPTVNEVEAEFWRHVA 2000
                                                 ||:        ..|| ..||.||||.|.
Frog   391 HCPKCVMAECKRPPEAFGFEQATREFTLQSFGEMADAFKADYFNMPVHMVPT-ELVEKEFWRLVN 454

  Fly  2001 VRDSHVCVHSGS-IDSSGWGYGFP--------SPGPKGKGSNYARHPWNLKVLTNNSGSVLRSL- 2055
            ..:..|.|..|: |.|..:|.|||        ||..|.    ||...|||.|:.....|||..:
Frog   455 SIEEDVTVQYGADIHSKEFGSGFPMLDGKTELSPEEKA----YATSGWNLNVMPVLEQSVLCHIN 515

  Fly  2056 GPVMGVTVPTLHVGMLFSACCWYRDPHGLSWIEYLHTGASKLWYGIPDDQSANFRAALTSLIPTH 2120
            ..:.|:.||.|:|||:|||.||:.:.|....|.|||.|..|.|||:|...:......:..|.|..
Frog   516 ADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSSAAEQLEDVMKKLTPEL 580

  Fly  2121 CQNKTIWLPCDTVMVPPHMLTDRGVSLCRIEQKPGEFIVVFPRAYTSSLATGYVVSESVYFATMS 2185
            .:::...|.....::.|:.|...||.:.|..|..|||::.|||||.|....||..:|:|.|.|..
Frog   581 FESQPDLLHQLVTLMNPNTLMAHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTAD 645

  Fly  2186 WLDLAK---DDFRDIHESCEPAMFSLEQLLFAL-GYDQRVN---SEALHQMLPMLNDVCEKESAA 2243
            ||...:   :.:|.:...|   :||.|:|:..: ...:|::   :.|:|:.:.:|   .::|...
Frog   646 WLPAGRKCIEHYRRLRRYC---VFSHEELICKMAACPERLDMSLAAAVHKEMFLL---VQEERRL 704

  Fly  2244 REQLRAAGVTSTEKVQAEKGQKAKKQQQPPYKSIESECDLCRANLYISMVRTED--GNIYCLQHA 2306
            |:.|...|||..|:...|.           ....|.:|..|:...::|.:...|  ..:.||.|
Frog   705 RKTLLEQGVTEAEREAFEL-----------LPDDERQCQKCKTTCFLSALACYDCPQGLVCLYH- 757

  Fly  2307 LKNLNNGNIQAKQCK-----LIYAYNVDDIQQLIRQLQ 2339
            :::|       .||.     |.|.|.:|::..::.:|:
Frog   758 IEDL-------CQCPPSRQYLRYRYTLDELPAMLHKLK 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jarid2	NP_648324.1	JmjN	1740..1781	CDD:128818	21/40 (53%)
		ARID	1812..1893	CDD:279697	24/90 (27%)
		JmjC	2066..2181	CDD:202224	42/114 (37%)
		zf-C5HC2	2281..2334	CDD:280996	14/59 (24%)
kdm5c	NP_001072719.1	JmjN	14..55	CDD:128818	21/40 (53%)
		BRIGHT	81..171	CDD:128777	24/94 (26%)
		PHD_SF	350..395	CDD:304600	1/44 (2%)
		JmjC	525..641	CDD:202224	42/115 (37%)
		zf-C5HC2	731..783	CDD:280996	14/59 (24%)
		PLU-1	796..1119	CDD:285609
		PHD2_KDM5C_5D	1198..1255	CDD:277081
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D664180at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10694
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110