DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jarid2 and Jarid2

DIOPT Version :9

Sequence 1:	NP_648324.1	Gene:	Jarid2 / 39103	FlyBaseID:	FBgn0036004	Length:	2351	Species:	Drosophila melanogaster
Sequence 2:	XP_017456196.1	Gene:	Jarid2 / 681740	RGDID:	1591663	Length:	1281	Species:	Rattus norvegicus

Alignment Length:	1474	Identity:	387/1474 - (26%)
Similarity:	617/1474 - (41%)	Gaps:	348/1474 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   993 PPPIEA-YQCPKINPNFLTPKYERSPLPRSSTSSFPSPS----------------PVKF------ 1034
            |||... :.|..|| |.|             :...||||                |:.:
  Rat     2 PPPFSVQFSCRHIN-NLL-------------SDCLPSPSAPAGVRLSYCLAESALPLAYYVLGRI 52

  Fly  1035 -QPTSGTTATTVGTPSSATKSPLAPPPPSPPVSQVVIQTSSLNLSMSIAATVNAAPMPVASTSAA 1098
             ...||...|....            |||||:|..:...:...|.|                  |
  Rat    53 VDKCSGACLTAFSL------------PPSPPLSFFLCLCNDPALRM------------------A 87

  Fly  1099 AAHQTTVATTVTATSTPP----PAHSNSAATGGGAGANSDPLKDEIGSILAQATLMPSKE-ESG- 1157
            |.....|...|.....|.    ..:..|.|. |.|...|:..||:...:.:.:..:.|.: |.|
  Rat    88 APRVCQVQFLVAYLEEPGIEGLLGNDQSKAL-GPASEQSENEKDDASQVSSTSNDVSSSDFEEGP 151

  Fly  1158 -----KIFGIASVSLAQSSGPDNTKCTLGKCGSIHKPV--LGPVVPTEGYFGDQLSSKERRKAKV 1215
                 ::......:.:|.:.|..|            ||  :.|::|..   ...:|...:||.|.
  Rat   152 SRKRPRLQAQRKFAQSQPNSPSTT------------PVKTVEPLLPPP---ATHISDLSKRKPKT 201

  Fly  1216 N--MT------HEQIQKWLIECSSNPDEIQDDLDDDFDDSLRPQQSTTPPPTRDDKELSASFSSS 1272
            .  :|      ...:...::...|:.||  :|::::.|:            |.|.|..:.:.|||
  Rat   202 EDFLTFLCLRGSPALPNSMVYFGSSQDE--EDVEEEDDE------------TEDVKTATNNASSS 252

  Fly  1273 SKNTRGDLGKSESAWSAKGPSLKATPVLVTPPNRKELHEQADSKDCDALDYDKSSTPVNLTQKIT 1337
            .::|           ..||.|            .|.:|               :....|     .
  Rat   253 CQST-----------PRKGKS------------HKHVH---------------NGHVFN-----G 274

  Fly  1338 SNESLAVEKKVNDRKGKES--AKAAASKAATQPRSTAATPPTPISSTPTPASLTPSKSSPTPPPA 1400
            ||.|...::.....:|:|:  .|...|:.....|...|:...|.::.|..:|.....:|..|||:
  Rat   275 SNRSAREKEPAQKHRGREATPGKEKHSEHRADGRREQASVAQPTANPPAGSSTKGLAASHQPPPS 339

  Fly  1401 VKQKAEKGKRNATAGGGATALASPPAAPTPA--------NPKRTPVYNQKNAKA--------QQQ 1449
             .:.|:..::..:...|.|.::|..|....|        :|.:|..|.....|.        ::.
  Rat   340 -HRSAQDSRKQVSKVNGVTRMSSLGAGTNSAKKIREVRPSPSKTVKYTATVTKGTVTYTKAKREL 403

  Fly  1450 QAETKPASNPPSGAGTKRESVYAFGKDDESGSKSGNRRRTDPSPVPAPALVPNALSERSPTKKRA 1514
            ..||||:.:.||.|.....|    ||.:.|.:|:..:                .||....:...|
  Rat   404 VKETKPSHHKPSSAVNHTIS----GKSESSNAKTRKQ----------------VLSLGGASTSTA 448

  Fly  1515 AAAAAATAVQLTLSPTENCKIEGKPSKAPTGRGAKK---QQQQAPAPPAPPVEASGDSDAEGATF 1576
            .||:...| ...|:|....|..|........|.:|:   :.||.....:||.:..|.:
  Rat   449 PAASGLKA-SSRLNPKSCTKEVGGRQLREGLRNSKRRLEEAQQVDKQQSPPKKMKGTA------- 505

  Fly  1577 YIPLQGAGVGGSGDGGIQGVAVKLGREGPDGPNQKVVMQATLVTKAQMDTNSKPLPE-SLNTNEL 1640
                              |:|...||:......:|.::...:         .|.:|| ||..|.
  Rat   506 ------------------GIAEAPGRKASAASGEKSLLNGHV---------KKEVPERSLERNR- 542

  Fly  1641 VKTLLHAASNDAASTTTSLKSLPKASTSAAAGAAAAPGASSLVRVNSNSSLFSGSAKSRTAAQTS 1705
                                  ||   .||||       .:::...::........::|:.:|..
  Rat   543 ----------------------PK---RAAAG-------KNMLGKQAHGKSEGTPCENRSTSQPE 575

  Fly  1706 STAAAVAKKYKDDTPIKMANNTAFPRHDDPTQMVEAPIFRPTEKEFADPIEFIERITPIAARFGI 1770
            |:......:.|   |.|.:..:.:...|      |.|:.||:.|||.||:.:||.:.....::|:
  Rat   576 SSHKPHDPQGK---PEKGSGKSGWAAMD------EIPVLRPSAKEFHDPLIYIESVRAQVEKYGM 631

  Fly  1771 CKIIPPASFKPECRISDEMRFTAYNQYVHKMLHRWGPSAKELSAIKKYLATQSIVMNHPPWIGGM 1835
            |::|||..::|||:::|||||....|::||:..||||:.:.|:.|||:|.:|.|.|:..|.|||.
  Rat   632 CRVIPPPDWRPECKLNDEMRFVTQIQHIHKLGRRWGPNVQRLACIKKHLRSQGITMDELPLIGGC 696

  Fly  1836 EVDLPRLYHTVQELGGLKEVIEKKKWARVAEEMCIPKLAQDRVTKLDDIYCKYLLPYDTLSPAER 1900
            |:||...:..:.|:||:::|.:.|||.::|:.:.|||.||||:.||.:.||:|||.||:|||.|.
  Rat   697 ELDLACFFRLINEMGGMQQVTDLKKWNKLADMLRIPKTAQDRLAKLQEAYCQYLLSYDSLSPEEH 761

  Fly  1901 QKLFDEV------------------EADWAKREARAR-------------RNADRF----VNTES 1930
            ::|..||                  |.|..|..:..|             ||..|.    |....
  Rat   762 RRLEKEVLMEKEILEKRKGPLEGHTENDHHKFHSLPRFEPKNGLIHGVTPRNGFRSKLKEVGRAP 826

  Fly  1931 VSNEEDDLSSDEDE--ESEEEIDGV---SMECIVKGRSMPLSQFYRIARNTMALWFKSTDPTVNE 1990
            :......|.:.|.|  :.|||..||   ..:||.||||:.|:.|||.|||.|.:.| |.:|...|
  Rat   827 LKTGRRRLFAQEKEVVKEEEEDKGVLDDFYKCIYKGRSVSLTTFYRTARNIMNMCF-SKEPAPAE 890

  Fly  1991 VEAEFWRHVAVRDSHVCVHSGSIDSSGWGYGFPSPGPKGKGSNYARHPWNLKVLTNNSGSVLRSL 2055
            :|.|:||.|..:|.||.||.|.:|::..|.||    |.||...::||.|||.||.||:||:||.|
  Rat   891 IEQEYWRLVEEKDCHVAVHCGKVDTNTHGSGF----PVGKSEPFSRHGWNLTVLPNNTGSILRHL 951

  Fly  2056 GPVMGVTVPTLHVGMLFSACCWYRDPHGLSWIEYLHTGASKLWYGIPDDQSANFRAALTSLIPTH 2120
            |.|.|||:|.|::||:||..||.||.:.|.:|:||||||..:||.||.::.......:.:|:.
  Rat   952 GAVPGVTIPWLNIGMVFSTSCWSRDQNHLPYIDYLHTGADCIWYCIPAEEENKLEDVVHTLLQ-- 1014

  Fly  2121 CQNKTIWLPC--DTVMVPPHMLTDRGVSLCRIEQKPGEFIVVFPRAYTSSLATGYVVSESVYFAT 2183
             .|.|..|..  ..||:.|.:|...|:.:.|..|:.|:|:|.||.::.|.:..||.|||:|:|||
  Rat  1015 -GNGTPGLQMLESNVMISPEVLCKEGIKVHRTVQQSGQFVVCFPGSFVSKVCCGYNVSETVHFAT 1078

  Fly  2184 MSWLDLAKDDFRDIHESCEPAMFSLEQLLFALGYDQ--RVNSEALHQMLPMLNDVCEKESAAREQ 2246
            ..|..:..:..:::........||:|:||:.:...:  :.|...|..:..:|:::.:.|...|.|
  Rat  1079 TQWTSMGFETAKEMKRRHIAKPFSMEKLLYQIAQAEAKKENGPTLSTISALLDELRDTELRQRRQ 1143

  Fly  2247 LRAAGVTSTEKVQAEKGQ------KAKKQQQPPYKSIESECDLCRANLYISMVRTEDGN-IYCLQ 2304
            |..||:.|:.:..:..|.      |.|.::....::.|..|.:|:...|:|||..|:.| ::||:
  Rat  1144 LFEAGLHSSARYGSHDGSSAVADGKKKPRKWLQLETSERRCQICQHLCYLSMVVQENENVVFCLE 1208

  Fly  2305 HALKNLNNGNIQAKQC---KLIYAYNVDDIQQLIRQLQEKINHK 2345
            .||:::.    :.|.|   ||:|.|:.:.|..|:.|:..|::.|
  Rat  1209 CALRHVE----KQKSCRGLKLMYRYDEEQIISLVNQICGKVSGK 1248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jarid2	NP_648324.1	JmjN	1740..1781	CDD:128818	16/40 (40%)
		ARID	1812..1893	CDD:279697	37/80 (46%)
		JmjC	2066..2181	CDD:202224	44/116 (38%)
		zf-C5HC2	2281..2334	CDD:280996	19/56 (34%)
Jarid2	XP_017456196.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334776
Domainoid	1	1.000	114	1.000	Domainoid score	I5948
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D664180at2759
OrthoFinder	1	1.000	-	-		FOG0007182
OrthoInspector	1	1.000	-	-		oto96460
orthoMCL	1	0.900	-	-		OOG6_109452
Panther	1	1.100	-	-	O	PTHR10694
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5293
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.840