DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jarid2 and KDM5A

DIOPT Version :9

Sequence 1:	NP_648324.1	Gene:	Jarid2 / 39103	FlyBaseID:	FBgn0036004	Length:	2351	Species:	Drosophila melanogaster
Sequence 2:	NP_001036068.1	Gene:	KDM5A / 5927	HGNCID:	9886	Length:	1690	Species:	Homo sapiens

Alignment Length:	765	Identity:	190/765 - (24%)
Similarity:	294/765 - (38%)	Gaps:	184/765 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1740 EAPIFRPTEKEFADPIEFIERITPIAARFGICKIIPPASFKP--ECRISDEMRFTAYNQYVHKML 1802
            |.|:|.|:.:||.||:.||.||.|:|.:.|||||.||..::|  .|.:. ..|||...|.::::.
Human    18 ECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPPFACEVK-SFRFTPRVQRLNELE 81

  Fly  1803 HRWGPSAKELSAIKKYLATQSIVMNHPPWIGGMEVDLPRLYHTVQELGGLKEVIEKKKWARVAEE 1867
            .........|..:.|:...|...:..|. :....:||..|...|...||.:.|.::|||::|...
Human    82 AMTRVRLDFLDQLAKFWELQGSTLKIPV-VERKILDLYALSKIVASKGGFEMVTKEKKWSKVGSR 145

  Fly  1868 M-CIPKLAQDRVTKLDDIYCKYLLPYDTLSPAE------------RQKLFDEVEA--DWAKREAR 1917
            : .:|  .:...:.|...|.:.|.||:......            ::|:..||.:  .....|..
Human   146 LGYLP--GKGTGSLLKSHYERILYPYELFQSGVSLMGVQMPNLDLKEKVEPEVLSTDTQTSPEPG 208

  Fly  1918 ARRN----ADRFVNTESVSNEEDDLSSDED--------------------EESEEEI-------- 1950
            .|.|    ..|.|.|:|   |..|:|.:.:                    ::.|:|:
Human   209 TRMNILPKRTRRVKTQS---ESGDVSRNTELKKLQIFGAGPKVVGLAMGTKDKEDEVTRRRKVTN 270

  Fly  1951 --DGVSME-------------------------------------------CIV-------KG-- 1961
              |..:|:                                           |::       ||
Human   271 RSDAFNMQMRQRKGTLSVNFVDLYVCMFCGRGNNEDKLLLCDGCDDSYHTFCLIPPLPDVPKGDW 335

  Fly  1962 -----------------------RSMPLSQFYRIARNTMALWFK---STDPTVNEVEAEFWRHVA 2000
                                   |...|..|..:|.|..:.:|.   ...|| ..||.||||.|:
Human   336 RCPKCVAEECSKPREAFGFEQAVREYTLQSFGEMADNFKSDYFNMPVHMVPT-ELVEKEFWRLVS 399

  Fly  2001 VRDSHVCVHSGS-IDSSGWGYGFPSPGPKGK----GSNYARHPWNLKVLTNNSGSVLRSLG-PVM 2059
            ..:..|.|..|: |.|..:|.|||....:.|    ...||...|||..:.....|||..:. .:.
Human   400 SIEEDVIVEYGADISSKDFGSGFPVKDGRRKILPEEEEYALSGWNLNNMPVLEQSVLAHINVDIS 464

  Fly  2060 GVTVPTLHVGMLFSACCWYRDPHGLSWIEYLHTGASKLWYGIPDDQSANFRAALTSLIPTHCQNK 2124
            |:.||.|:|||.||:.||:.:.|....|.|||.|..|.|||:|...:......:..|.|...:::
Human   465 GMKVPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQ 529

  Fly  2125 TIWLPCDTVMVPPHMLTDRGVSLCRIEQKPGEFIVVFPRAYTSSLATGYVVSESVYFATMSWLDL 2189
            ...|.....::.|::|.:.||.:.|..|..|||:|.|||||.|....||..:|:|.|.|..||.:
Human   530 PDLLHQLVTIMNPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPI 594

  Fly  2190 AK---DDFRDIHESCEPAMFSLEQLLFALGYDQRVNSEALHQML-PMLNDVCEKESAAREQLRAA 2250
            .:   :.:|.:...|   :||.|:|:|.:..|.......|..|: ..|..:.|:|:..||.:...
Human   595 GRQCVNHYRRLRRHC---VFSHEELIFKMAADPECLDVGLAAMVCKELTLMTEEETRLRESVVQM 656

  Fly  2251 GVTSTEKVQAEKGQKAKKQQQPPYKSIESECDLCRANLYISMV--RTEDGNIYCLQHALKNLNNG 2313
            ||..:|:...|.           ....|.:|..||...::|.:  ......:.||.|. .:|...
Human   657 GVLMSEEEVFEL-----------VPDDERQCSACRTTCFLSALTCSCNPERLVCLYHP-TDLCPC 709

  Fly  2314 NIQAKQCKLIYAYNVDDIQQLI------------------RQLQEKINHK 2345
            .:| |:| |.|.|.::|:..|:                  ..|....|||
Human   710 PMQ-KKC-LRYRYPLEDLPSLLYGVKVRAQSYDTWVSRVTEALSANFNHK 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jarid2	NP_648324.1	JmjN	1740..1781	CDD:128818	21/40 (53%)
		ARID	1812..1893	CDD:279697	20/81 (25%)
		JmjC	2066..2181	CDD:202224	42/114 (37%)
		zf-C5HC2	2281..2334	CDD:280996	15/54 (28%)
KDM5A	NP_001036068.1	JmjN	18..59	CDD:128818	21/40 (53%)
		ARID	85..170	CDD:198082	20/87 (23%)
		PHD1_KDM5A	295..343	CDD:277075	3/47 (6%)
		GSGFP motif. /evidence=ECO:0000250\|UniProtKB:Q3UXZ9	419..423		2/3 (67%)
		JmjC	470..586	CDD:202224	42/115 (37%)
		zf-C5HC2	676..728	CDD:280996	15/54 (28%)
		PLU-1	741..1070	CDD:285609	4/17 (24%)
		PHD2_KDM5A	1163..1215	CDD:277079
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1327..1348
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1407..1433
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1490..1509
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1516..1543
		PHD3_KDM5A	1608..1659	CDD:277156
		Interaction with LMO2. /evidence=ECO:0000269\|PubMed:9129143	1623..1690
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I12140
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D664180at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10694
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920