DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jarid2 and kdm5c

DIOPT Version :9

Sequence 1:	NP_648324.1	Gene:	Jarid2 / 39103	FlyBaseID:	FBgn0036004	Length:	2351	Species:	Drosophila melanogaster
Sequence 2:	NP_001116706.1	Gene:	kdm5c / 553406	ZFINID:	ZDB-GENE-060810-94	Length:	1578	Species:	Danio rerio

Alignment Length:	812	Identity:	190/812 - (23%)
Similarity:	310/812 - (38%)	Gaps:	238/812 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1740 EAPIFRPTEKEFADPIEFIERITPIAARFGICKIIPPASFKPECRIS-DEMRFTAYNQYVHKMLH 1803
            |.|:|.|:.:|||||:.:|.:|.|||.:.|||||.||..::|...:. |...||...|.::::..
Zfish    13 ECPVFEPSWEEFADPLGYIAKIRPIAEKSGICKIRPPPDWQPPFAVEVDNFHFTPRIQRLNELEA 77

  Fly  1804 RWGPSAKELSAIKKYLATQSIVMNHPPWIGGME---VDLPRLYHTVQELGGLKEVIEKKKWARVA 1865
            ........|..|.|:...|...:..|    .:|   :||..|...|.|.||.:.|.::::|||||
Zfish    78 ETRVKLNYLDRIAKFWEIQGSSLKIP----NLERRILDLFSLAKIVTEEGGFESVSKERRWARVA 138

  Fly  1866 EEMCIPKLAQDRVTKLDDIYCKYLLPYD------TLSPAE-RQKLFDEVEADWAKREARAR---- 1919
            :::..|. .::..:.|...|.:.:.|::      :|.|.: ||...|||:.::.......|
Zfish   139 QKLGYPP-GKNIGSLLRSHYERIVYPFELFQSGASLPPRKPRQYDSDEVDREYKPHSIPLRQSVP 202

  Fly  1920 --------RNADRF--------------VNTESVSNEE--------------------------- 1935
                    |.|:|.              ..::.:|:.|
Zfish   203 PSKMSSYGRRANRLQPEGPEDPTHHPLTTGSQHISSPEPTEEDIEKNPELKKLQIYGAGPKMMGL 267

  Fly  1936 -----------DDL--------SSDEDEESE--------------------EEIDG--------- 1952
                       |||        |:.:||.:|                    |::|.
Zfish   268 GLVPRDKTRKKDDLPQTVIVRDSAVKDEPAETAVTKSDPDIPPPPPNLIIKEDVDDDKSHIDKPN 332

  Fly  1953 ---------VSME-----------------------------------------CIV-------K 1960
                     ::|.                                         |::       |
Zfish   333 DPSDEPCTKMTMRLRRNLNNPQFVDSFVCRMCGRGDEDEKLMLCDGCDDNYHTFCLIPPLTDPPK 397

  Fly  1961 G-------------------------RSMPLSQFYRIARNTMALWFK---STDPTVNEVEAEFWR 1997
            |                         |...|..|..:|....|.:|.   ...|| ..||.||||
Zfish   398 GNWRCPKCVAEECKKPSEAFGFEQATREYTLQSFGEMADTFKADYFNMPVHMVPT-ELVEKEFWR 461

  Fly  1998 HVAVRDSHVCVHSGS-IDSSGWGYGFPSPGPKGKGS----NYARHPWNLKVLTNNSGSVLRSL-G 2056
            .|:..:..|.|..|: |.|..:|.|||....|.:.|    .|||..|||.|:.....|:|..: .
Zfish   462 LVSSIEEDVTVEYGADIHSKEFGSGFPVNNGKRQLSEEEEEYARSGWNLNVMPVLEQSLLCHINA 526

  Fly  2057 PVMGVTVPTLHVGMLFSACCWYRDPHGLSWIEYLHTGASKLWYGIPDDQSANFRAALTSLIPTHC 2121
            .:.|:.||.|:|||:|||.||:.:.|....|.|||.|..|.|||:|...:......:..|.|...
Zfish   527 DISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPCSAAEKLEEVMKKLTPELF 591

  Fly  2122 QNKTIWLPCDTVMVPPHMLTDRGVSLCRIEQKPGEFIVVFPRAYTSSLATGYVVSESVYFATMSW 2186
            :.:...|.....::.|::|...||.:.|..|..|||::.|||||.|....||..:|:|.|.|..|
Zfish   592 EFQPDLLHQLVTIMNPNILMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADW 656

  Fly  2187 LDLAK---DDFRDIHESCEPAMFSLEQL---LFALGYDQRVN-SEALHQMLPMLNDVCEKESAAR 2244
            |...:   :.:|.:...|   :||.|:|   :.|......:| :.|.|:.:.:   :.::|...|
Zfish   657 LPTGRSCIEHYRQLRRYC---VFSQEELTCKMAACPEKLDLNLAAATHREMFI---IVQEERKLR 715

  Fly  2245 EQLRAAGVTSTEKVQAEKGQKAKKQQQPPYKSIESECDLCRANLYISMVRTED--GNIYCLQHAL 2307
            :.|...|:...|:...|.           ....|.:||.|:...::|.:...:  ..:.||.||
Zfish   716 KSLLERGIKEAEREAFEL-----------LPDDERQCDKCKTTCFLSALACSNCPERLVCLYHA- 768

  Fly  2308 KNLNNGNIQAKQCKLIYAYNVDDIQQLIRQLQ 2339
            ::|  .:..:::..|.|.|.:|::..::.:|:
Zfish   769 QDL--CSCPSEKLYLRYRYTLDELLAMLHRLK 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jarid2	NP_648324.1	JmjN	1740..1781	CDD:128818	21/40 (53%)
		ARID	1812..1893	CDD:279697	23/83 (28%)
		JmjC	2066..2181	CDD:202224	42/114 (37%)
		zf-C5HC2	2281..2334	CDD:280996	13/54 (24%)
kdm5c	NP_001116706.1	JmjN	13..54	CDD:128818	21/40 (53%)
		BRIGHT	80..170	CDD:128777	23/94 (24%)
		PHD1_KDM5C_5D	360..405	CDD:277077	3/44 (7%)
		JmjC	535..651	CDD:202224	42/115 (37%)
		zf-C5HC2	741..793	CDD:280996	13/54 (24%)
		PLU-1	806..1134	CDD:285609
		PHD2_KDM5C_5D	1254..1311	CDD:277081
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11657
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D664180at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10694
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920