Protein Alignment Jarid2 and Kdm6b

DIOPT Version :10

• Sequence 1: NP_648324.1
• Gene: Jarid2 / 39103
• FlyBaseID: FBgn0036004
• Length: 2351
• Species: Drosophila melanogaster
• Sequence 2: XP_038942397.1
• Gene: Kdm6b / 363630
• RGDID: 1307629
• Length: 1636
• Species: Rattus norvegicus
• Alignment Length: 1950
• Identity: 382/1950 - (19%)
• Similarity: 605/1950 - (31%)
• Gaps: 687/1950 - (35%)

  Fly   190 EKPSTAEKPASDKNNLIAAEAPKIPSRNPTP--------VLPGAVRKRAEVVTDGNRRGARGRGA 246
            :.|.:|..|.|..|:......|...|..|||        .|.|.|:
  Rat    53 QPPLSAPLPPSHGNSSGHPNKPYYASGTPTPRPLHGKLESLHGCVQ------------------- 98

  Fly   247 GISHDKTTPAALSKDNKRRSNRASTKESKPVIDDDNSEDLDE-QEADDDEDEFFSAHDATSRNGE 310
                      ||.::           .::||:    .|.|.: .|::.|.:|....:....|.|.
  Rat    99 ----------ALLRE-----------PAQPVL----WEQLGQLYESEHDSEEAICCYHRALRYGG 138

  Fly   311 EVKADSPVKAEPTKRGRPSAAK-------------KAVEPAPEGQTVL-----------KDKAPV 351
            ......|      :.||...|:             |.:.|..:...:|           :...||
  Rat   139 SFAELGP------RIGRLQQAQLWNLHAGSCQHRAKVLPPLEQVWNLLHLEHKRNYGAKRGGPPV 197

  Fly   352 KRVRQRESPIFIPSPE------------SSGRMTRQRAFFEPVKVPPHKEEPGAHDPPKDEPKKQ 404
            |  |..|.|:..|.|.            |.|...|:....|...:||....|   .||...|...
  Rat   198 K--RSAEPPVVQPMPPAALSGPSGEEGLSPGGKRRRGCSSEQAGLPPGLPLP---PPPPPPPPPP 257

  Fly   405 PETPPSKTEKEQEPTKQIKEAKEKTNSSIYAKEAKQQLENGDSLHGAVAKGKKSLNVFDFSSDDE 469
            |..||...     |...|....:.|...::           ::|||
  Rat   258 PPPPPPPL-----PGLAISPPFQLTKPGLW-----------NTLHG------------------- 287

  Fly   470 QPLAKSIKLKKGAKGASPKKGGAAPIAPAARNRKAAAKKLDKEKEIEKEKQREKEEEIERDKAKE 534
                       .|.|  |::.|:||  |                  |:::||
  Rat   288 -----------DAWG--PERKGSAP--P------------------ERQEQR------------- 306

  Fly   535 KKDKEKEKEKEKHPVPESKVEEPPSGGKRGKA-----GKKKAEDAPADEEDLAPPSSKKVATNAR 594
                  ......||.|.......|...:.|.|     |.:    .|..|.....|:::...::.|
  Rat   307 ------HSLPHPHPYPAPAYTAHPPSHRLGPATPLGPGPR----PPGAESHGCLPATRPPGSDLR 361

  Fly   595 GSR-------KSAKSKASEDSAELEPQRSQ-RPSRKTKEAAAIYMGIIGHKLQLADDEEDDLSMS 651
            .||       .|....||.......|.|.. .|...:..:::...|:.|              :.
  Rat   362 ESRVQRSRMDSSVSPAASTACVPYAPSRPPGLPGTSSSSSSSNNTGLRG--------------VE 412

  Fly   652 SFPDIPNVKEMEKMENEIKRNAAGKLNVPEASTVLSAGKSTRKPSPRPKDSPVTAPVEATRNESP 716
            ..|.||.....:....||         .|..:.:..:..|:|||.   ..:|..||..:..:.:|
  Rat   413 PSPGIPGADHYQNPALEI---------APHQARLGPSAHSSRKPF---LTAPAAAPHLSLPSGTP 465

  Fly   717 SPPEAEEEKPPPPARRGRPPKQNKVNAGPAHKPRIEGMLVKKGSLAKMSEQQAKPKAKSEHSKVD 781
            |.|      |||..|..|||                                 .|.|..:.|...
  Rat   466 SSP------PPPCPRLLRPP---------------------------------PPPAWMKGSACR 491

  Fly   782 SDEEEDFLINEELNETKRKLEKSFSDSDDEPLAIKVPAVAVKEKELLPPKMASPPPKLVPVPSPI 846
            |..|:..::.|           .|..::.                  ||:  .|||.|......:
  Rat   492 SAREDGEILGE-----------LFFGAEG------------------PPR--PPPPPLPHRDGFL 525

  Fly   847 SVPTPAVSVAPSLA-VPSILPTSTGTTQLTMLPLTAKATSSLGSMPMFPS--IQASYSPL----- 903
            ..|.|..||....: .|...||:|.::. :.....:.::|..|.:|..|.  :..|..||
  Rat   526 GPPNPRFSVGTQDSHTPPTPPTTTSSSS-SSSSSNSHSSSPTGPVPFPPPPYLARSIDPLPRPSS 589

  Fly   904 KTMEKK-PPVPTSKILNVPATYALPGSASGAVSFQKTSSYLPQASPHYHSGYVRP----PPTPTH 963
            .|:..: ||:|       |.|.|||.:...:.....:.|:....||       ||    |.||
  Rat   590 PTLSSQDPPLP-------PLTLALPPAPPSSCHQNTSGSFRRSESP-------RPRVSFPKTP-- 638

  Fly   964 QFGGGAPSGS-------------KTPSQGSSPLKYQTPPTTYPPPIE-AYQCP---KINPNFLT- 1010
            :.|.|.|.||             :.|::|  |..:..|||    |:| .::.|   ||.|:.|.
  Rat   639 EVGQGPPPGSLSKAPQPVPPGVGELPARG--PRLFDFPPT----PLEDQFEEPAEFKILPDGLAN 697

  Fly  1011 --------------------------PKYE-----RSPLPRSSTSSFPSPSPVKFQPTSGTTATT 1044
                                      |..|     ||.|| |.|:  |:.:.....||:.||.||
  Rat   698 IMKMLDESIRKEEEQQQQEAGAVPPPPLKEPFASLRSSLP-SDTA--PAATTAAATPTTTTTTTT 759

  Fly  1045 -----VGTPSSATKSPLA--PPPPSPPVSQVVIQTSSLNLSMSIAATVNAAPMPVASTSAAAAHQ 1102
                 ...|:.....|||  ||||.||...   ..|..:|..|:|:.:.........|.||.
  Rat   760 QEEEKKPPPALPPPPPLAKFPPPPQPPPPP---PASPASLLKSLASVLEGQKYCYRGTGAAV--- 818

  Fly  1103 TTVATTVTATS-TPPPAHSNSAATGGGAGANSDPLKDEIGSILAQATLMPSKEESGKIFGIASVS 1166
            :|...:|.||. :|.||          :||.:.|          ..::.||.:.|.|....:|..
  Rat   819 STRPGSVPATQYSPSPA----------SGATAPP----------PTSVAPSAQGSPKPSVSSSSQ 863

  Fly  1167 LAQSSGPDNTKCTLGKCGSIHKPVLGPVVPTEGYFGDQL---------SSKERRKAKVNMTHEQI 1222
            .:.|.||...:...|:     :|..|||.|.      ||         .|:.....:::...|.:
  Rat   864 FSTSGGPWVRERRAGE-----EPAPGPVTPA------QLPPPLPLPPARSESEVLEEISRACETL 917

  Fly  1223 QKWLIECSSNP-DEIQDDLDDDFDDSLRPQQSTTPPPTRDDKELSASFSSSSKNTRGDLGKSES- 1285
            .:.:...:.|| |.:  |:.|..|....||    |||.:                    .|.||
  Rat   918 VERVGRSAINPADPV--DIADPVDSGTEPQ----PPPAQ--------------------AKEESG 956

  Fly  1286 --AWSAKGPSLKATPVLVTPPNRKELHEQADSKDCDALDYDKSSTPVNLTQKITSNESLAVEKKV 1348
              |.:|.||............:|:...:....:..:.....|:..|...::::..|..|..|
  Rat   957 GVAVAAAGPGSGKRRQKEHRRHRRTCRDSVGRRPREGRAKAKAKAPKEKSRRVLGNLDLQSE--- 1018

  Fly  1349 NDRKGKESAK---AAASKAATQPRSTAATPPTPI-SSTPTPASLTPSKSSPTPPPAVKQKAEKGK 1409
             :.:|:|.|:   ..|||..|.  :|.|.||.|. |:.|||.|        .|.|..|.:.|
  Rat  1019 -EIQGREKARPDVGGASKVKTP--TTPAPPPAPAPSAQPTPPS--------APVPGKKTREE--- 1069

  Fly  1410 RNATAGGGATALASPPAAPTPANPKRTPVYNQKNAKAQQQQAETKPASNPPSGAGTKRESVYAFG 1474
                             ||.|....|..:...::.           :..||.....:...|
  Rat  1070 -----------------APGPPGVSRADMLKLRSL-----------SEGPPKELKIRLIKV---- 1102

  Fly  1475 KDDESGSKSGNRRRTDPSPVPAPALVPNALSERSPTKKRAAAAAAATAVQLTLSPTENCKIEGK- 1538
               |||.|.              ..:.:.:.||   :.|.|....:......:..::|.|::||
  Rat  1103 ---ESGDKE--------------TFIASEVEER---RLRMADLTISHCAADVMRASKNAKVKGKF 1147

  Fly  1539 ------PSKA--PTGRGAKKQQQQAPAPPAPPVEASGDSDAEGATFYIP--LQGA---------- 1583
                  |:::  |.....:|..::...||.|.:......||     :.|  ||..
  Rat  1148 RESYLSPAQSVKPKINTEEKLPREKLNPPTPSIYLESKRDA-----FSPVLLQFCTDPRNPITVI 1207

  Fly  1584 -GVGGSGDGGIQGVAVKLGREGPDGPNQKVVMQA----TLVTKAQMDTNSKPLPESLNTNEL--- 1640
             |:.||       :.:.||..     :.|.:::|    |:..:.|:...|....:...|.::
  Rat  1208 RGLAGS-------LRLNLGLF-----STKTLVEASGEHTVEVRTQVQQPSDENWDLTGTRQIWPC 1260

  Fly  1641 -----VKTLLHAASNDAASTTTSLKSLPKA---------STSAAAGAAAAPGASS--LVRVNSNS 1689
                 ..|:...|...|:|...||:...::         ||:..:.:::||...:  :::..:|.
  Rat  1261 ESSRSHTTIAKYAQYQASSFQESLQEEKESEDEESEEPDSTTGTSPSSSAPDPKNHHIIKFGTNI 1325

  Fly  1690 SLFSGSAKSRTAAQTSSTAAAVAKKYKDDTPIKMANNTAF----------------PRHDDPTQM 1738
            .| |.:.:.:...|......|..:.......:....:|..                |.|.:....
  Rat  1326 DL-SDAKRWKPQLQELLKLPAFMRVTSTGNMLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNF 1389

  Fly  1739 VEAPI-FRPTEKE-FADPIEFIERITPIAARFGICKIIPPASFKPECRISDEMRFTAYNQYVHKM 1801
            ....| ..|.:.| ||....:.|.|:....|.|:..:  ..|:.|   |.|::  .|.|..|::.
  Rat  1390 CSVNINIGPGDCEWFAVHEHYWETISAFCDRHGVDYL--TGSWWP---ILDDL--YASNIPVYRF 1447

  Fly  1802 LHR-------------------------W--GPSAKELSAIKKYLA-----------TQSIV-MN 1827
            :.|                         |  ||    |:|.:..||           .:||| |.
  Rat  1448 VQRPGDLVWINAGTVHWVQATGWCNNIAWNVGP----LTAYQYQLALERYEWNEVKNVKSIVPMI 1508

  Fly  1828 HPPWIGGMEVDL--PRLYHTVQELGGLKEVIEKKKWARVAEEMCI---PKLA-QDRVTKLDDIYC 1886
            |..|.....|.:  |.|:..::..     :::..|..:|..|..:   .|:| |.||......||
  Rat  1509 HVSWNVARTVKISDPDLFKMIKFC-----LLQSMKHCQVQRESLVRAGKKIAYQGRVKDEPAYYC 1568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jarid2	NP_648324.1	PHA03247	<157..429	CDD:223021	54/283 (19%)
		Atrophin-1	762..>986	CDD:460830	53/249 (21%)
		JmjN	1740..1781	CDD:128818	10/42 (24%)
		ARID_JARD2	1804..1915	CDD:350634	26/127 (20%)
		cupin_RmlC-like	2066..2181	CDD:477354
		zf-C5HC2	2281..2334	CDD:460750
Kdm6b	XP_038942397.1	BepA	<90..154	CDD:443813	17/113 (15%)
		TPR repeat	106..136	CDD:276809	7/33 (21%)
		JmjC	1336..1400	CDD:214721	7/63 (11%)
		JmjC	1370..1478	CDD:396791	20/114 (18%)