DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jarid2 and kdm5ba

DIOPT Version :9

Sequence 1:	NP_648324.1	Gene:	Jarid2 / 39103	FlyBaseID:	FBgn0036004	Length:	2351	Species:	Drosophila melanogaster
Sequence 2:	NP_001334536.1	Gene:	kdm5ba / 327168	ZFINID:	ZDB-GENE-030131-5379	Length:	1478	Species:	Danio rerio

Alignment Length:	749	Identity:	188/749 - (25%)
Similarity:	290/749 - (38%)	Gaps:	176/749 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1732 HDDPTQMV---EAPIFRPTEKEFADPIEFIERITPIAARFGICKIIPPASFKP--ECRISDEMRF 1791
            |..|.:.:   |.|:|.|:.:|||||..||.:|.|||...|||||.||..::|  .|.: |.:.|
Zfish     3 HSRPNEFIPPPECPVFEPSWEEFADPFGFINKIRPIAENTGICKIRPPPGWQPPFACDV-DRLHF 66

  Fly  1792 TAYNQYVHKMLHRWGPSAKELSAIKKYLATQSIVMNHPPWIGGMEVDLPRLYHTVQELGGLKEVI 1856
            |...|.::::..:.......|..|.|:...|...:. .|.:....:||..||..|:|.||...|.
Zfish    67 TPRIQRLNELEAQTRVKLNFLDQIAKFWELQGCTLK-IPHVERKTLDLFVLYKLVKEDGGFDVVC 130

  Fly  1857 EKKKWARVAEEMCI------------------------------------PKLAQDRVTKLDDIY 1885
            ::::|.::|.:|..                                    |.|..|  || |..|
Zfish   131 KERRWTQIALKMGFAPGKAIGSHLRAHYERILYPYYLFQTGANLMQNSQKPTLTND--TK-DKEY 192

  Fly  1886 CKYLL-------PYDTLSPAERQK-----LFDEVEADWAKREARARRNADRFVNTESVS------ 1932
            ..:.|       |.:|.:.|.|.|     .|.....:..:.:...||....:|......
Zfish   193 KPHDLPQRQSVQPVETCTIARRAKRTEGRCFKSEPGEVCENKPNLRRRMGSYVAKPEPGTFKMLP 257

  Fly  1933 ---NEEDDLSSDEDEESEEE------------------IDG------------------------ 1952
               .||..:...:.|:|:.|                  .||
Zfish   258 VQVKEEPIVQPVDGEKSKVEQYICLVCGGGGDEDRLLLCDGCDDSYHTFCLIPPLHDVPKGDWRC 322

  Fly  1953 ---VSMECIVKGRSMPLSQFYRIARN-------TMALWFKS--------TDPTVNEVEAEFWRHV 1999
               ::.||   |:......|.:..|:       .||..|||        ..|| ..||.||||.|
Zfish   323 PKCLAQEC---GKPQVAFGFEQAPRDYTLRTFGDMADSFKSDYFNMPVHMVPT-ELVEKEFWRLV 383

  Fly  2000 AVRDSHVCVHSGS-IDSSGWGYGFP--------SPGPKGKGSNYARHPWNLKVLTNNSGSVLRSL 2055
            :..:..|.|..|: |.|..:|.|||        ||..:|    |....|||..:.....|||..:
Zfish   384 STIEEDVTVEYGADIASKDFGSGFPVKNGTFKVSPEEEG----YLTSGWNLNNMPVLEASVLTHV 444

  Fly  2056 -GPVMGVTVPTLHVGMLFSACCWYRDPHGLSWIEYLHTGASKLWYGIPDDQSANFRAALTSLIPT 2119
             ..:.|:.:|.|:|||.||:.||:.:.|....:.|||.|..|.|||.|...:......:..|.|.
Zfish   445 TADICGMKLPWLYVGMCFSSFCWHIEDHWSYSVNYLHWGEPKTWYGAPGYAAEQLEDVMKGLAPE 509

  Fly  2120 HCQNKTIWLPCDTVMVPPHMLTDRGVSLCRIEQKPGEFIVVFPRAYTSSLATGYVVSESVYFATM 2184
            ..:::...|.....::.|::|.:.||.:.|..|..|||::.|||||.|....|:..:|:|.|.|.
Zfish   510 LFESQPDLLHQLVTIMNPNLLMEHGVPIYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTA 574

  Fly  2185 SWLDLAK---DDFRDIHESCEPAMFSLEQLLFALGYDQRVNSEALHQMLPMLNDVCEKESAAREQ 2246
            .||.|.:   :.:|.::..|   :||.:::..      .:.::|         |..|.|.|...|
Zfish   575 DWLPLGRQCVEHYRSLYRYC---VFSHDEMAC------NIAAKA---------DSLELELACAVQ 621

  Fly  2247 LRAAGVTSTEKVQAEKGQKAK--KQQQPPYKSI---ESECDLCRANLYISMVR--TEDGNIYCLQ 2304
            .....:...||:..||..|..  ..||..|..:   |.:|..||...|:|.:.  .....:.||.
Zfish   622 KDMNAMIQEEKILREKAYKLGMWHSQQVDYDILPDEERQCAKCRTTCYLSAITCPCSPEQVVCLH 686

  Fly  2305 HALKNLNNGNIQAKQCKLIYAYNVDDIQQLIRQL 2338
            |. ::|  .:..|:...|.|.|.:.:::...:.|
Zfish   687 HT-QDL--CSCPARNYTLNYKYTLAELKTFFQAL 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jarid2	NP_648324.1	JmjN	1740..1781	CDD:128818	22/40 (55%)
		ARID	1812..1893	CDD:279697	26/123 (21%)
		JmjC	2066..2181	CDD:202224	39/114 (34%)
		zf-C5HC2	2281..2334	CDD:280996	13/54 (24%)
kdm5ba	NP_001334536.1	JmjN	14..55	CDD:128818	22/40 (55%)
		BRIGHT	81..171	CDD:128777	17/90 (19%)
		PHD1_KDM5B	280..325	CDD:277076	2/44 (5%)
		JmjC	455..571	CDD:202224	39/115 (34%)
		zf-C5HC2	661..712	CDD:308530	13/53 (25%)
		PLU-1	726..1046	CDD:312061
		PHD_SF	1145..1188	CDD:328929
		PHD3_KDM5B	1422..1471	CDD:277157
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11657
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D664180at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10694
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.020