Protein Alignment Jarid2 and KDM6B

DIOPT Version :10

• Sequence 1: NP_648324.1
• Gene: Jarid2 / 39103
• FlyBaseID: FBgn0036004
• Length: 2351
• Species: Drosophila melanogaster
• Sequence 2: NP_001073893.1
• Gene: KDM6B / 23135
• HGNCID: 29012
• Length: 1682
• Species: Homo sapiens
• Alignment Length: 1784
• Identity: 352/1784 - (19%)
• Similarity: 551/1784 - (30%)
• Gaps: 620/1784 - (34%)

  Fly   324 KRGRPSAAKKAVEPAPEGQTVLKDKAPVKRVRQRESPIFIPSPE-----SSGRMTRQRAFFEPVK 383
            |||.| ..|:|.||.               |.|...|..:..|.     |.|...|:....|...
Human   191 KRGGP-PVKRAAEPP---------------VVQPVPPAALSGPSGEEGLSPGGKRRRGCNSEQTG 239

  Fly   384 VPPHKEEPGAHDPPKDEPKKQPETPPSKTEKEQEPTKQIKEAKEKTNSSIYAKEAKQQLENGDSL 448
            :||....|....||  .|...|..||........|..|:      |...:::           :|
Human   240 LPPGLPLPPPPLPP--PPPPPPPPPPPLPGLATSPPFQL------TKPGLWS-----------TL 285

  Fly   449 HGAVAKGKKSLNVFDFSSDDEQPLAKSIKLKKGAKGASPKKGGAAPIAPAARNRKAAAKKLDKEK 513
            ||                              .|.|  |::.|:||
Human   286 HG------------------------------DAWG--PERKGSAP------------------- 299

  Fly   514 EIEKEKQREKEEEIERDKAKEKKDKEKEKEKEKHPVP---ESKVEEPPSGGKRGKAGKKKAEDAP 575
                                  .::::::....||.|   .:....||        |.:....||
Human   300 ----------------------PERQEQRHSLPHPYPYPAPAYTAHPP--------GHRLVPAAP 334

  Fly   576 ADEEDLAPPSSKKVATNARGSRKSAKSKASEDSAELEPQRSQRPSRKTKEAAAIYM--------G 632
            ..      |..:.....:.|...:.:...| |..|...|||:..|..:..|....:        |
Human   335 PG------PGPRPPGAESHGCLPATRPPGS-DLRESRVQRSRMDSSVSPAATTACVPYAPSRPPG 392

  Fly   633 IIGHKLQLADDEEDDLSMSSF---PDIPNVKEMEKMENEIKRNAAGKLNVPEASTVLSAGKSTRK 694
            :.|.....:.....:..:...   |.||.....:....|:..:  |:|. |.|       .|:||
Human   393 LPGTTTSSSSSSSSNTGLRGVEPNPGIPGADHYQTPALEVSHH--GRLG-PSA-------HSSRK 447

  Fly   695 PSPRPKDSPVTAPVEATRNESPSPPEAEEEKPPPPARRGRPPKQNKVNAGPAHKPRIEGMLVKKG 759
            |.       :.||. ||.:.| .||......|||..|..|||.......|||
Human   448 PF-------LGAPA-ATPHLS-LPPGPSSPPPPPCPRLLRPPPPPAWLKGPA------------- 490

  Fly   760 SLAKMSEQQAKPKAKSEHSKVDSDEEEDFLINEELNETKRKLEKSFSDSDDEPLAIKVPAVAVKE 824
                       .:|..|..::                    ||:.|..::.
Human   491 -----------CRAAREDGEI--------------------LEELFFGTEG-------------- 510

  Fly   825 KELLPPKMASPP-PK----LVPVPSPISVPTPAVSVAPSLAVPSILPTSTGTTQLTMLPLTAKAT 884
                ||:.|.|| |.    |.|..|..||.|......|:   |   ||          |.|:.:.
Human   511 ----PPRPAPPPLPHREGFLGPPASRFSVGTQDSHTPPT---P---PT----------PTTSSSN 555

  Fly   885 SSLGSMPMFPSIQASYSPLKTMEK------KPPVPTSKILN---VPATYALP--------GSASG 932
            |:.||....|:...|:.|...:.:      :||.|.....:   ||.|.|||        .:.||
Human   556 SNSGSHSSSPAGPVSFPPPPYLARSIDPLPRPPSPAQNPQDPPLVPLTLALPPAPPSSCHQNTSG 620

  Fly   933 A----------VSFQKTSSYLPQASPHYHSGYVRPPPTPTHQFGGGAPSG-SKTPSQGSSPLKYQ 986
            :          |||.||    |:..|       .|||.|..:.....|.| .:.|::|  |..:.
Human   621 SFRRPESPRPRVSFPKT----PEVGP-------GPPPGPLSKAPQPVPPGVGELPARG--PRLFD 672

  Fly   987 TPPTTYPPPIE-AYQCP---KINPNFLT----------------PKYERSPLP----RSSTSSFP 1027
            .|||    |:| .::.|   ||.|:.|.                .::|....|    :...:|..
Human   673 FPPT----PLEDQFEEPAEFKILPDGLANIMKMLDESIRKEEEQQQHEAGVAPQPPLKEPFASLQ 733

  Fly  1028 SPSPVKFQPTSG------TTATTVGTPSSATKS-------------PLA---------PPPPSPP 1064
            ||.|....||:.      ||.||..|.::||:.             |||         ||||.||
Human   734 SPFPTDTAPTTTAPAVAVTTTTTTTTTTTATQEEEKKPPPALPPPPPLAKFPPPSQPQPPPPPPP 798

  Fly  1065 VSQVVIQTSSLNLSMSIAATVNAAPMPVASTSAAAAHQTTVATTVTATSTPPPAHSNSAATGGGA 1129
                    |..:|..|:|:.:.........|.||            .::.|.|..:...:.|..:
Human   799 --------SPASLLKSLASVLEGQKYCYRGTGAA------------VSTRPGPLPTTQYSPGPPS 843

  Fly  1130 GANSDPLKDEIGSILAQATLMPSKEESGKIFGIASVSLAQSSGPDNTKCTLGKCGSIHKPVLGPV 1194
            ||.:.|......|  ||.:..||...|.:        .:.|.||...:...|:     :||.||:
Human   844 GATALPPTSAAPS--AQGSPQPSASSSSQ--------FSTSGGPWARERRAGE-----EPVPGPM 893

  Fly  1195 VPTEGYFGDQLSSKERRKAKVNMTHEQIQKWLIECSSNPDEIQDDLDDDFD--DSLRPQQSTTP- 1256
            .||:.  ...||....|.....:  |:|.:   .|.:..:.:.....|..|  |:..|..|.|.
Human   894 TPTQP--PPPLSLPPARSESEVL--EEISR---ACETLVERVGRSATDPADPVDTAEPADSGTER 951

  Fly  1257 --PPTRDDKELS--ASFSSSSKNTRGDLGKSESAWSAKGPSLKATPVLVTPPNRKELHEQADSKD 1317
              ||.:..:|..  |:.|.|.|..:.:..|....                  :|:...:....:.
Human   952 LLPPAQAKEEAGGVAAVSGSCKRRQKEHQKEHRR------------------HRRACKDSVGRRP 998

  Fly  1318 CDALDYDKSSTPVNLTQKITSNESLAVEKKVNDRKGKESAK---AAASKAATQPRSTAATPPTPI 1379
            .:.....|:..|...::::..|..|..|    :.:|:|.::   ..|||         |.|||
Human   999 REGRAKAKAKVPKEKSRRVLGNLDLQSE----EIQGREKSRPDLGGASK---------AKPPT-- 1048

  Fly  1380 SSTPTPASLTPSKSSPTPPPAVKQKAEKGKRNATAGGGATALASPPAAPTPANPKRTPVYNQKNA 1444
              .|.|.|.....:.||||.|    :..||:            :...||.|....|..:...::.
Human  1049 --APAPPSAPAPSAQPTPPSA----SVPGKK------------AREEAPGPPGVSRADMLKLRSL 1095

  Fly  1445 KAQQQQAETKPASNPPSGAGTKRESVYAFGKDDESGSKSGNRRRTDPSPVPAPALVPNALSERSP 1509
                       :..||.....:...|       |||.|.              ..:.:.:.||
Human  1096 -----------SEGPPKELKIRLIKV-------ESGDKE--------------TFIASEVEER-- 1126

  Fly  1510 TKKRAAAAAAATAVQLTLSPTENCKIEGK-------PSKA--PTGRGAKKQQQQAPAPPAPPVEA 1565
             :.|.|....:......:..:.|.|::||       |:::  |.....:|..::...||.|.:..
Human  1127 -RLRMADLTISHCAADVVRASRNAKVKGKFRESYLSPAQSVKPKINTEEKLPREKLNPPTPSIYL 1190

  Fly  1566 SGDSDAEGATFYIP--LQGA-----------GVGGSGDGGIQGVAVKLGREGPDGPNQKVVMQA- 1616
            ....||     :.|  ||..           |:.||       :.:.||..     :.|.:::|
Human  1191 ESKRDA-----FSPVLLQFCTDPRNPITVIRGLAGS-------LRLNLGLF-----STKTLVEAS 1238

  Fly  1617 ---TLVTKAQMDTNSK------------PLPESLNTNELVKTLLHAASNDAASTTTSLKS----- 1661
               |:..:.|:...|.            |...|.:...:.|...:.||:...|.....:|
Human  1239 GEHTVEVRTQVQQPSDENWDLTGTRQIWPCESSRSHTTIAKYAQYQASSFQESLQEEKESEDEES 1303

  Fly  1662 -LPKASTSAAAGAAAAPGASSLVRVNSNSSLFSGSAKSRTAAQTSSTAAAVAKKYKDDTPIKMAN 1725
             .|.::|.....:|..|....:::..:|..| |.:.:.:...|......|..:.......:....
Human  1304 EEPDSTTGTPPSSAPDPKNHHIIKFGTNIDL-SDAKRWKPQLQELLKLPAFMRVTSTGNMLSHVG 1367

  Fly  1726 NTAF----------------PRHDDPTQMVEAPI-FRPTEKE-FADPIEFIERITPIAARFGICK 1772
            :|..                |.|.:........| ..|.:.| ||....:.|.|:....|.|:..
Human  1368 HTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFAVHEHYWETISAFCDRHGVDY 1432

  Fly  1773 IIPPASFKPECRISDEMRFTAYNQYVHKMLHR-------------------------W--GPSAK 1810
            :  ..|:.|   |.|::  .|.|..|::.:.|                         |  ||
Human  1433 L--TGSWWP---ILDDL--YASNIPVYRFVQRPGDLVWINAGTVHWVQATGWCNNIAWNVGP--- 1487

  Fly  1811 ELSAIKKYLA-----------TQSIV-MNHPPWIGGMEVDL--PRLYHTVQELGGLKEVIEKKKW 1861
             |:|.:..||           .:||| |.|..|.....|.:  |.|:..::..     :::..|.
Human  1488 -LTAYQYQLALERYEWNEVKNVKSIVPMIHVSWNVARTVKISDPDLFKMIKFC-----LLQSMKH 1546

  Fly  1862 ARVAEEMCI---PKLA-QDRVTKLDDIYC 1886
            .:|..|..:   .|:| |.||......||
Human  1547 CQVQRESLVRAGKKIAYQGRVKDEPAYYC 1575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jarid2	NP_648324.1	PHA03247	<157..429	CDD:223021	27/109 (25%)
		Atrophin-1	762..>986	CDD:460830	56/256 (22%)
		JmjN	1740..1781	CDD:128818	10/42 (24%)
		ARID_JARD2	1804..1915	CDD:350634	27/128 (21%)
		cupin_RmlC-like	2066..2181	CDD:477354
		zf-C5HC2	2281..2334	CDD:460750
KDM6B	NP_001073893.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	52..88
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	190..680		146/725 (20%)
		PRK12323	<572..718	CDD:481241	39/162 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	704..807		26/110 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	822..1096		73/369 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1288..1325		6/36 (17%)
		JmjC	1343..1407	CDD:214721	7/63 (11%)
		JmjC	1377..1485	CDD:396791	20/114 (18%)