DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jarid2 and Kdm6a

DIOPT Version :9

Sequence 1:	NP_648324.1	Gene:	Jarid2 / 39103	FlyBaseID:	FBgn0036004	Length:	2351	Species:	Drosophila melanogaster
Sequence 2:	XP_006527657.1	Gene:	Kdm6a / 22289	MGIID:	1095419	Length:	1476	Species:	Mus musculus

Alignment Length:	905	Identity:	167/905 - (18%)
Similarity:	282/905 - (31%)	Gaps:	332/905 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   611 LEPQRSQRPSRKTKEAAAI-YM---------GIIGHKLQLADDEEDDLSMSSFPDIPNVKEMEKM 665
            |...||:..|..:..||.| |:         |.:.:|.:|               :|:::|
Mouse   378 LNATRSKNCSNTSGLAARIKYLQAQLCNLPQGSLQNKTKL---------------LPSIEE---- 423

  Fly   666 ENEIKRNAAGKLNVPEASTVLSAGKSTRKPSPRPKDSPVTAPVEATRNESP-----------SPP 719
                    |..|.:|...|......:|.:.:.:| ..|.|.||... :::|           .|.
Mouse   424 --------AWSLPIPAELTSRQGAMNTAQQACKP-HHPNTEPVLGL-SQTPISQQSLPLHMIPPS 478

  Fly   720 EAEEEKPPPPARRGRPPKQNKV------NAGPAHKPRIEGMLVKKGSLAKMSEQQAKPKAKSEHS 778
            :.::...|...:|...|.:|..      ||.|..:.:.....:....|..:.:.:|.
Mouse   479 QVDDLSSPAKRKRTSSPTKNTSDNWSGGNAPPPVEQQTHSWCLTPQKLQHLEQLRAN-------- 535

  Fly   779 KVDSDEEEDFLINEELNETKR----KLEKSFSDSDDEPLAIKVPAVAVKEKELLPPKMASPPPKL 839
                        ...||..::    :||..|              |.:::.::....:|...|..
Mouse   536 ------------RNNLNPAQKLMLEQLESQF--------------VLMQQHQMRQTGVAQVRPTG 574

  Fly   840 VPVPSPISVPTPAVSVAPSLAVPSILPTSTGTTQLTMLPLTAKATSSLGSMPMFPSIQASYSPLK 904
            :     ::.||          |.|.|||::.:.|...||||...:.|.      |.:..: .|.:
Mouse   575 I-----LNGPT----------VDSSLPTNSVSGQQPQLPLTRMPSVSQ------PGVHTA-CPRQ 617

  Fly   905 TMEKKP------PVPTSKILNVPATYAL-----PGSAS-GAVSF-QKTSSYLPQASPHYHSGYVR 956
            |:...|      |..||:.|....|..:     .||.| |.|.: |:.:..||....:..|....
Mouse   618 TLANGPFSAGHVPCSTSRTLGSTDTVLIGNNHVTGSGSNGNVPYLQRNAPTLPHNRTNLTSSTEE 682

  Fly   957 P--------------PPTPTHQFG--GGAPSGSKTPSQ----GSSPLKYQTPPTTYPP------- 994
            |              .|: :|..|  |..|..|..|||    ..|.::.|....|.|.
Mouse   683 PWKNQLSNSTQGLHKGPS-SHLAGPNGERPLSSTGPSQHLQAAGSGIQNQNGHPTLPSNSVTQGA 746

  Fly   995 ---PIEAYQCPKINPNFLTPKYERSP------LPRSSTSSFPSPSPVKFQPTSGTTATTVGTPSS 1050
               .:.::.........:|...|..|      :|.:|..:..:|:         :||:..|.|:.
Mouse   747 ALNHLSSHTATSGGQQGITLTKESKPSGNTLTVPETSRQTGETPN---------STASVEGLPNH 802

  Fly  1051 A---------------TKSPLAPPPPSPPVSQVVIQTSSLNLSMSIAATVN-------------- 1086
            .               :|||......:|.:|.:::..::.|:.......||
Mouse   803 VHQVMADAVCSPSHGDSKSPGLLSSDNPQLSALLMGKANNNVGPGTCDKVNNIHPTVHTKTDNSV 867

  Fly  1087 -AAPMPVASTSAAAAHQTTVATTVTATSTPPPAHSNSAATGGGAGANSDPLKDEIGSILAQATLM 1150
             ::|....||:..:...|...||.:.||...|........|.|...:..|:|.::        |:
Mouse   868 ASSPSSAISTATPSPKSTEQTTTNSVTSLNSPHSGLHTINGEGMEESQSPIKTDL--------LL 924

  Fly  1151 PSKEESGKIFGIASVSLAQSS-------------GPDNTKCTLGKC------GSIHKPV----LG 1192
            .|...|.:|....|||:..||             |..|:...|.||      .|.:.|:    |.
Mouse   925 VSHRPSPQIIPSMSVSIYPSSAEVLKACRNLGKNGLSNSSILLDKCPPPRPPSSPYPPLPKDKLN 989

  Fly  1193 PVVPT-------EGYF------------------------------------------------- 1201
            |..|:       :.:|
Mouse   990 PPTPSIYLENKRDAFFPPLHQFCTNPNNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRT 1054

  Fly  1202 ---------GDQLSSKERRKAKVNMTHEQIQKWL-IECSSNPDEIQDDLDDDFDDSLRPQQSTTP 1256
                     .|...:|:....:.|.:|..|.|:. .:.||            |.:|||.:..
Mouse  1055 QLLQPADENWDPTGTKKIWHCESNRSHTTIAKYAQYQASS------------FQESLREENE--- 1104

  Fly  1257 PPTRDDKELSASFSSSSKNTRGDLGKSESAWSAKGP--SLKATPVLVTPPNRK---ELHE 1311
             .....|:.|.|.|:||.|:    ||..     |||  ::|....:....::|   :|||
Mouse  1105 -KRSHHKDHSDSESTSSDNS----GKRR-----KGPFKTIKFGTNIDLSDDKKWKLQLHE 1154

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jarid2	NP_648324.1	JmjN	1740..1781	CDD:128818
		ARID	1812..1893	CDD:279697
		JmjC	2066..2181	CDD:202224
		zf-C5HC2	2281..2334	CDD:280996
Kdm6a	XP_006527657.1	TPR repeat	95..123	CDD:276809
		TPR	108..401	CDD:223533	8/22 (36%)
		TPR repeat	131..161	CDD:276809
		TPR repeat	166..196	CDD:276809
		TPR repeat	207..235	CDD:276809
		TPR repeat	287..314	CDD:276809
		TPR repeat	319..349	CDD:276809
		TPR repeat	354..380	CDD:276809	1/1 (100%)
		JmjC	1151..1215	CDD:214721	3/4 (75%)
		JmjC	1185..1293	CDD:334913
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900