DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jarid2 and Kdm6b

DIOPT Version :9

Sequence 1:	NP_648324.1	Gene:	Jarid2 / 39103	FlyBaseID:	FBgn0036004	Length:	2351	Species:	Drosophila melanogaster
Sequence 2:	XP_030101676.1	Gene:	Kdm6b / 216850	MGIID:	2448492	Length:	1642	Species:	Mus musculus

Alignment Length:	1796	Identity:	359/1796 - (19%)
Similarity:	542/1796 - (30%)	Gaps:	645/1796 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   324 KRGRPSAAKKAVEPAPEGQTVLKDKAPVKRVRQRESPIFIPSPE------------SSGRMTRQR 376
            |||.|                     |||  |..|.|:..|.|.            |.|...|:.
Mouse   191 KRGGP---------------------PVK--RSAEPPVVQPMPPAALSGPSGEEGLSPGGKRRRG 232

  Fly   377 AFFEPVKVPPHKEEPGAHDPPKDEPKKQPETPPSKTEKEQEPTKQIKEAKEKTNSSIYAKEAKQQ 441
            ...|...:||....|....||...|...|..||..      |...|....:.|...::
Mouse   233 CSSEQAGLPPGLPLPPPPPPPPPPPPPPPPPPPPL------PGLAISPPFQLTKPGLW------- 284

  Fly   442 LENGDSLHGAVAKGKKSLNVFDFSSDDEQPLAKSIKLKKGAKGASPKKGGAAPIAPAARNRKAAA 506
                ::|||                              .|.|  |::.|:||
Mouse   285 ----NTLHG------------------------------DAWG--PERKGSAP------------ 301

  Fly   507 KKLDKEKEIEKEKQREKEEEIERDKAKEKKDKEKEKEKEKHPVPES----------------KVE 555
                                             .|:::::|.:|.|                .|.
Mouse   302 ---------------------------------PERQEQRHSMPHSYPYPAPAYSAHPPSHRLVP 333

  Fly   556 EPPSGGKRGKAGKKKAEDAPADEEDLAPPSSKKVATNARGSR-KSAKSKASEDSAELEPQRSQRP 619
            ..|.|......|.:.....||..    ||.|....:..:.|| .|:.|.|:  |....|....||
Mouse   334 NTPLGPGPRPPGAESHGCLPATR----PPGSDLRESRVQRSRMDSSVSPAA--STACVPYAPSRP 392

  Fly   620 -------SRKTKEAAAIYMGIIGHKLQLADDEEDDLSMSSFPDIPNVKEMEKMENEIKRNAAGKL 677
                   |..:..:::...|:.|              :...|.||.....:....||.
Mouse   393 PGLPGTSSSSSSSSSSNNTGLRG--------------VEPSPGIPGADHYQNPALEIS------- 436

  Fly   678 NVPEASTVLSAGKSTRKPSPRPKDSPVTAPVEATRNESPSPPEAEEEKPPPPARRGRPPKQNKVN 742
              |..:.:..:..|:|||.       :|||. ||.:.| .||......|||..|..|||..
Mouse   437 --PHQARLGPSAHSSRKPF-------LTAPA-ATPHLS-LPPGTPSSPPPPCPRLLRPPPP---- 486

  Fly   743 AGPAHKPRIEGMLVKKGSLAKMSEQQAKPKAKSEHSKVDSDEEEDFLINEELNETKRKLEKSFSD 807
              ||.         .|||..:.:                   .||..|..||          |..
Mouse   487 --PAW---------MKGSACRAA-------------------REDGEILGEL----------FFG 511

  Fly   808 SDDEPLAIKVPAVAVKEKELLPPKMASPPPKLVPVPSPISVPTPAVSVAPSLA-VPSILPTSTGT 871
            ::.                  ||:  .|||.|......:..|.|..||....: .|.|.||:|.:
Mouse   512 AEG------------------PPR--PPPPPLPHRDGFLGPPNPRFSVGTQDSHNPPIPPTTTSS 556

  Fly   872 TQLTMLPLTAKATSSLGSMPMFPS--IQASYSPL-----KTME-KKPPVPTSKILNVPATYALP- 927
            :..:    .:.::|..|.:|..|.  :..|..||     .|:. :.||:|       |.|.|||
Mouse   557 SSSS----NSHSSSPTGPVPFPPPSYLARSIDPLPRPSSPTLSPQDPPLP-------PLTLALPP 610

  Fly   928 -------GSASGAVSFQKTSSYLPQAS----PHYHSGYVRPPPTPTHQFGGGAPSG-SKTPSQGS 980
                   .:.||  ||:::.|..|:.|    |....|   |||.|..:.....|.| .:.|::|
Mouse   611 APPSSCHQNTSG--SFRRSESPRPRVSFPKTPEVGQG---PPPGPVSKAPQPVPPGVGELPARG- 669

  Fly   981 SPLKYQTPPTTYPPPIE-AYQCP---KINPNFLT----------PKYER---------SPLP--- 1019
             |..:..|||    |:| .::.|   ||.|:.|.          .|.|.         :|.|
Mouse   670 -PRLFDFPPT----PLEDQFEEPAEFKILPDGLANIMKMLDESIRKEEEQQQQQEAGVAPPPPLK 729

  Fly  1020 ---RSSTSSFPS---PSPVKFQPTSGTTATTVGT----------------PSSATKSPLAP---P 1059
               .|....|||   |:.....||:.||.||..|                |....|.|..|   |
Mouse   730 EPFASLQPPFPSDTAPATTTAAPTTATTTTTTTTTTTQEEEKKPPPALPPPPPLAKFPPPPQPQP 794

  Fly  1060 PPSPPVSQVVIQTSSLNLSMSIAATVNAAPMPVASTSAAAAHQTTVATTVTATS-TPPPAHSNSA 1123
            ||.||.|..       :|..|:|:.:.........|.||.   :|...:|.||. :|.||
Mouse   795 PPPPPASPA-------SLLKSLASVLEGQKYCYRGTGAAV---STRPGSVPATQYSPSPA----- 844

  Fly  1124 ATGGGAGANSDPLKDEIGSILAQATLMPSKEESGKIFGIASVSLAQSSGPDNTKCTLGKCGSIHK 1188
                 :||.:.|          ..::.||.:.|.|....:|...:.|.||...:...|:     :
Mouse   845 -----SGATAPP----------PTSVAPSAQGSPKPSVSSSSQFSTSGGPWAREHRAGE-----E 889

  Fly  1189 PVLGPVVPTEGYFGDQL---------SSKERRKAKVNMTHEQIQKWLIECSSNPDEIQDDLDDDF 1244
            |..|||.|.      ||         .|:.....:::...|.:.:.:...:.||    .|..|..
Mouse   890 PAPGPVTPA------QLPPPLPLPPARSESEVLEEISRACETLVERVGRSAINP----VDTADPV 944

  Fly  1245 DDSLRPQQSTTPPPTRDDKELSASFSSSSKNTRGDLGKSES---AWSAKGPSLKATPVLVTPPNR 1306
            |....||    |||.:                    .|.||   |.:|.||............:|
Mouse   945 DSGTEPQ----PPPAQ--------------------AKEESGGVAVAAAGPGSGKRRQKEHRRHR 985

  Fly  1307 KELHEQADSKDCDALDYDKSSTPVNLTQKITSNESLAVEKKVNDRKGKESAKAAASKAATQPRST 1371
            :...:....:..:.....|:..|...::::..|..|..|    :.:|:|.|:....
Mouse   986 RACRDSVGRRPREGRAKAKAKAPKEKSRRVLGNLDLQSE----EIQGREKARPDVG--------- 1037

  Fly  1372 AATPPTPISSTPTPASLTPSKSSPTPPPAVKQKAEKGKRNATAGGGATALASPPAAPTPANPKRT 1436
                  .:|...||       ::|.||||....|:               .:||:||.|....|
Mouse  1038 ------GVSKVKTP-------TAPAPPPAPAPAAQ---------------PTPPSAPVPGKKTR- 1073

  Fly  1437 PVYNQKNAKAQQQQAETKPASNPPSGAGTKRESVYAFGKDDESGSKSGNRRRTDPSPVPAPALVP 1501
                             :.|..||   |..|..:.......|...|....|............:.
Mouse  1074 -----------------EEAPGPP---GVSRADMLKLRSLSEGPPKELKIRLIKVESGDKETFIA 1118

  Fly  1502 NALSERSPTKKRAAAAAAATAVQLTLSPTENCKIEGK-------PSKA--PTGRGAKKQQQQAPA 1557
            :.:.||   :.|.|....:......:..::|.|::||       |:::  |.....:|..::...
Mouse  1119 SEVEER---RLRMADLTISHCAADVMRASKNAKVKGKFRESYLSPAQSVKPKINTEEKLPREKLN 1180

  Fly  1558 PPAPPVEASGDSDAEGATFYIP--LQGA-----------GVGGS--------------GDGGIQG 1595
            ||.|.:......||     :.|  ||..           |:.||              ...|...
Mouse  1181 PPTPSIYLESKRDA-----FSPVLLQFCTDPRNPITVIRGLAGSLRLNLGLFSTKTLVEASGEHT 1240

  Fly  1596 VAVKLGREGPDGPNQKVV------------MQATLVTKAQMDTNSKPLPESLNTNELVKTLLHAA 1648
            |.|:...:.|...|..:.            ...|:...||...:|  ..|||...|       ..
Mouse  1241 VEVRTQVQQPSDENWDLTGTRQIWPCESSRSHTTIAKYAQYQASS--FQESLQQEE-------RE 1296

  Fly  1649 SNDAASTTTSLKSLPKASTSAAAGAAAAPGASSLVRVNSNSSLFSGSAKSRTAAQTSSTAAAVAK 1713
            |.|..|..      |.::|..:..:|..|....:::..:|..| |.:.:.:...|......|..:
Mouse  1297 SEDEESEE------PDSTTGTSPSSAPDPKNHHIIKFGTNIDL-SDAKRWKPQLQELLKLPAFMR 1354

  Fly  1714 KYKDDTPIKMANNTAF----------------PRHDDPTQMVEAPI-FRPTEKE-FADPIEFIER 1760
            .......:....:|..                |.|.:........| ..|.:.| ||....:.|.
Mouse  1355 VTSTGNMLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFAVHEHYWET 1419

  Fly  1761 ITPIAARFGICKIIPPASFKPECRISDEMRFTAYNQYVHKMLHR--------------------- 1804
            |:....|.|:..:  ..|:.|   |.|::  .|.|..|::.:.|
Mouse  1420 ISAFCDRHGVDYL--TGSWWP---ILDDL--YASNIPVYRFVQRPGDLVWINAGTVHWVQATGWC 1477

  Fly  1805 ----W--GPSAKELSAIKKYLA-----------TQSIV-MNHPPWIGGMEVDL--PRLYHTVQEL 1849
                |  ||    |:|.:..||           .:||| |.|..|.....|.:  |.|:..::..
Mouse  1478 NNIAWNVGP----LTAYQYQLALERYEWNEVKNVKSIVPMIHVSWNVARTVKISDPDLFKMIKFC 1538

  Fly  1850 GGLKEVIEKKKWARVAEEMCI---PKLA-QDRVTKLDDIYC 1886
                 :::..|..:|..|..:   .|:| |.||......||
Mouse  1539 -----LLQSMKHCQVQRESLVRAGKKIAYQGRVKDEPAYYC 1574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jarid2	NP_648324.1	JmjN	1740..1781	CDD:128818	10/42 (24%)
		ARID	1812..1893	CDD:279697	23/93 (25%)
		JmjC	2066..2181	CDD:202224
		zf-C5HC2	2281..2334	CDD:280996
Kdm6b	XP_030101676.1	TPR repeat	106..136	CDD:276809
		JmjC	1342..1406	CDD:214721	7/63 (11%)
		JmjC	1376..1484	CDD:396791	20/114 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900