DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jarid2 and Kdm5d

DIOPT Version :9

Sequence 1:	NP_648324.1	Gene:	Jarid2 / 39103	FlyBaseID:	FBgn0036004	Length:	2351	Species:	Drosophila melanogaster
Sequence 2:	NP_035549.1	Gene:	Kdm5d / 20592	MGIID:	99780	Length:	1548	Species:	Mus musculus

Alignment Length:	799	Identity:	187/799 - (23%)
Similarity:	305/799 - (38%)	Gaps:	227/799 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1730 PRHDDPTQMVEAPIFRPTEKEFADPIEFIERITPIAARFGICKIIPPASFKPECRIS-DEMRFTA 1793
            |..||.....|.|:|.|:..||.||:.:|.:|.|||.:.|||||.|||.::|...:. |..|||.
Mouse     3 PGSDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRFTP 67

  Fly  1794 YNQYVHKMLHRWGPSAKELSAIKKYLATQSIVMNHPPWIGGME---VDLPRLYHTVQELGGLKEV 1855
            ..|.::::..:.......|..|.|:...|...:..|    .:|   :||..|...|.|.||.:.:
Mouse    68 RIQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIP----NVERKILDLYSLNKIVMEEGGYEAI 128

  Fly  1856 IEKKKWARVAEEMCIPKLAQDRVTKLDDIYCKYLLPY--------------DTLSPAERQKLF-- 1904
            .:.::|||||:.:..|. .::..:.|...|.:.:.||              |.....||.|.:
Mouse   129 CKDRRWARVAQRLNYPS-GKNIGSLLRSHYERIIYPYEIFQSGANLVQCNTDPFDSEERDKEYKP 192

  Fly  1905 --------------------------------DEVEADWAKREARARRNADRFVNTESVSNEEDD 1937
                                            :::|.:...::.:......:.:.....:.|:..
Mouse   193 HSIPLRQSVQPSKFSCYSRRGKRLQPEPEPTEEDIEKNPELKKLQIYGAGPKMIGLGLKAKEKTL 257

  Fly  1938 LSSDEDEESEEEI---------------------------------------------------- 1950
            ...|..:..:||:
Mouse   258 RKKDSKQPDKEEVTCPATIVVKGEASEFGKVTSAFSDKNLNHSFEPCMKMTMQLRNNHSSTQFMN 322

  Fly  1951 -------------------DGVS----MECIV-------KG------------RSMP-------- 1965
                               ||.|    :.|::       ||            :|.|
Mouse   323 SYVCRICSRGDEVDKFLLCDGCSDNYHIFCLLPPLSEVPKGVWRCPKCILAECKSPPEAFGFEQA 387

  Fly  1966 -----LSQFYRIARNTMALWFK---STDPTVNEVEAEFWRHVAVRDSHVCVHSGS-IDSSGWGYG 2021
                 |..|..:|.:..|.:|.   ...|| ..||.||||.|:..:..|.|..|: |.|..:|.|
Mouse   388 TQEYTLQSFGEMADSFKADYFNMPVHMVPT-EVVEKEFWRLVSSIEEDVTVEYGADIHSKEFGSG 451

  Fly  2022 FP--------SPGPKGKGSNYARHPWNLKVLTNNSGSVLRSL-GPVMGVTVPTLHVGMLFSACCW 2077
            ||        ||..|    .||...|||.|:.....|||..: ..:.|:.||.|:|||:|||.||
Mouse   452 FPVNNSKWDLSPEEK----EYAACGWNLNVMPVLDQSVLCHINADISGMKVPWLYVGMVFSAFCW 512

  Fly  2078 YRDPHGLSWIEYLHTGASKLWYGIPDDQSANFRAALTSLIPTHCQNKTIWLPCDTVMVPPHMLTD 2142
            :.:.|....|.|||.|..|.|||:|...:.:....:..|.|....::...|.....::.|:.|..
Mouse   513 HIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEDVMKRLTPELFDSQPDLLHQLVTLMNPNTLMS 577

  Fly  2143 RGVSLCRIEQKPGEFIVVFPRAYTSSLATGYVVSESVYFATMSWLDLAK---DDFRDIHESCEPA 2204
            .||.:.|..|..|||::.|||||.|....||..:|:|.|.|..||.:.:   :.:|.:...|
Mouse   578 HGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPVGRQCIEHYRRLRRYC--- 639

  Fly  2205 MFSLEQLLFAL-GYDQRVN---SEALH-QMLPMLNDVCEKESAAREQLRAAGVTSTEKVQAEKGQ 2264
            :||.|:|:..: .:.::::   :.|:| :|..|:    ::|...|:.|...|:|..|:...|.
Mouse   640 VFSHEELICKMAAFPEKLDLNLAVAVHKEMFIMV----QEERRLRKTLLEKGITEAEREAFEL-- 698

  Fly  2265 KAKKQQQPPYKSIESECDLCRANLYISMVRTED--GNIYCLQHALKNLNNGNIQAKQCK------ 2321
                     ....|.:|..|:...::|.:...|  .::.||.|    :|:      .||
Mouse   699 ---------LPDDERQCIKCKTTCFLSALACYDCPDSLVCLSH----IND------LCKCSRNRQ 744

  Fly  2322 -LIYAYNVDDIQQLIRQLQ 2339
             |.|.|.:|::..::::|:
Mouse   745 YLRYRYTLDELPAMLQKLK 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jarid2	NP_648324.1	JmjN	1740..1781	CDD:128818	21/40 (53%)
		ARID	1812..1893	CDD:279697	23/97 (24%)
		JmjC	2066..2181	CDD:202224	42/114 (37%)
		zf-C5HC2	2281..2334	CDD:280996	14/61 (23%)
Kdm5d	NP_035549.1	JmjN	13..54	CDD:128818	21/40 (53%)
		BRIGHT	80..170	CDD:128777	23/94 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	208..229		0/20 (0%)
		PHD1_KDM5C_5D	325..370	CDD:277077	6/44 (14%)
		JmjC	500..616	CDD:202224	42/115 (37%)
		zf-C5HC2	706..758	CDD:280996	14/61 (23%)
		PLU-1	771..1094	CDD:285609
		PHD_SF	1182..1242	CDD:304600
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1438..1468
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D664180at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10694
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920