DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jarid2 and utx-1

DIOPT Version :9

Sequence 1:	NP_648324.1	Gene:	Jarid2 / 39103	FlyBaseID:	FBgn0036004	Length:	2351	Species:	Drosophila melanogaster
Sequence 2:	NP_001309685.1	Gene:	utx-1 / 181110	WormBaseID:	WBGene00017046	Length:	1146	Species:	Caenorhabditis elegans

Alignment Length:	800	Identity:	145/800 - (18%)
Similarity:	259/800 - (32%)	Gaps:	282/800 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1704 TSSTAAAV----AKKYKDDTPIKMANNTAFPRHDDPTQMVEA-----PIFRPTEKE--------- 1750
            :|||...|    .:.|:...|:::.|.......|...|...|     ..||..|.|
Worm   449 SSSTFETVIPSLKEAYEQPIPLELRNRQDAAYADREAQYDNAFWDLWEDFRTMEHEKPEDMEWDV 513

  Fly  1751 -FADPIEFIERITPIAARFGICKII---PPASFKP-----ECRISDEMRFTAYNQYVHKMLHRWG 1806
             :..|:|.:|        ..:.:::   .||..|.     ||..:.|..|.|      |::....
Worm   514 TYPRPMEDLE--------IQVMQLLRANEPALVKAEREVLECLETSEAVFKA------KVIEYVI 564

  Fly  1807 PSA-KELSAIKKYLATQSIVMN---HPPWIGGMEVDLPRLYHTVQELGGLKEVIEKKKWARVAEE 1867
            |.| :|:..:     |:.::.|   |     |..::.||.|                      ..
Worm   565 PEAVREMPRV-----TEEMIQNLRDH-----GHLLESPRCY----------------------SF 597

  Fly  1868 MCIPKLA----QDRVTKLDDIYC--------------KYLLPYDTLSPAERQKLFDEVEADWAKR 1914
            ..:||::    .|..:.|.::|.              :...|..|..|     :|:|    :||.
Worm   598 PFLPKISFNDLPDSFSLLSELYVSMDISAQEIMQMVHRRTQPNSTYLP-----VFEE----FAKL 653

  Fly  1915 EARARRNADRFVNTESV-----SNEE------------DDLSSDEDEESEEEIDGVSMECIVKGR 1962
            ....|......|..|.|     .:|:            |:....:..|.:..:||.::.|| :|.
Worm   654 PEPPRGPVKPIVTDEDVRTALERSEKHPLILKTPILTVDNRKEAQSLELQRFLDGSTISCI-RGL 717

  Fly  1963 S----MPLSQF-------------------YRIARNT------MALWFKSTDP---TVN---EVE 1992
            :    :.||.|                   |::...|      ...|...:||   |||   |.:
Worm   718 TGCLRLDLSLFSTKAVAEIDGNQEIEIRTQYQLPPETNCDHASQQTWQCVSDPSYTTVNKYAEYQ 782

  Fly  1993 AEFWRHVAVRDSH-VCVHSGSIDSSGWGYGFPSPGPK-----GKGSNYARHPWNLKVLTN----- 2046
            :|.::|....::. :..:.|         |...|.||     .:.|:..:|..::|..||
Worm   783 SESFKHTLKGEAEKIKKNVG---------GTRGPSPKRMKLYKRASSPPKHLKSIKYGTNIDLSD 838

  Fly  2047 --------NSGSVLRSLGPVMGVTVPTLHVGMLFSACCWYRDPHGLSWIEYLHTGASKLWYGIPD 2103
                    |..|.|.:...::..:....|:|         ...||::.:        ||:..:|.
Worm   839 DTKWGKQINELSKLPAFCRLIAGSNMLSHLG---------HQVHGMNTV--------KLFMKVPG 886

  Fly  2104 -----DQSANFRAALT-SLIPTHCQ------------------------NKTIWLPCDTVMVPPH 2138
                 .|.:|..|::. ::.|..|:                        ..|.|...|.
Worm   887 CRTPAHQDSNHMASININIGPGDCEWFAVPYEYWGKMHKLCEKNGVDLLTGTFWPIIDD------ 945

  Fly  2139 MLTDRGVSLCRIEQKPGEFIVVFPRAYTSSLATGYVVSESVYFATMSWLDLAKDDFRDIHESCEP 2203
             |.|.|:.:.|..||.|:.:      |.|..|..: |..|.:...:|| ::|..:|:.:
Worm   946 -LLDAGIPVHRFTQKAGDMV------YVSGGAIHW-VQASGWCNNISW-NVAPLNFQQL------ 995

  Fly  2204 AMFSLEQLLFALGYDQRVNSEALHQML------------PMLNDVCEK---ESAAREQLRAAGVT 2253
               |:..|.:.....:|..||...|::            .::.:.|:.   .|.|..::.|..:.
Worm   996 ---SISLLSYEYNKLRRFKSEVPMQLMCWQVAKNVKFTNQLIYNTCKGVLIRSLAFLRMVADYIV 1057

  Fly  2254 STEKVQAEKGQKAKKQQQPPYKSIESECDLCRANLY-ISMVRTEDG--NIYCLQHALKNLNNGNI 2315
            |.:|  ..|.......:|..:      |..|...:: |..|:...|  .::|:..|......|.|
Worm  1058 SQKK--TIKAHTRTSGEQSHF------CMTCECEVFCILFVKDIGGKFTVFCVYCAKSQGIEGFI 1114

  Fly  2316 QAKQCKLIYAYNVDDIQQLI 2335
            ..:|......|::.|..:.|
Worm  1115 ALQQFSFTDLYSIYDNMKYI 1134

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jarid2	NP_648324.1	JmjN	1740..1781	CDD:128818	10/58 (17%)
		ARID	1812..1893	CDD:279697	13/101 (13%)
		JmjC	2066..2181	CDD:202224	27/144 (19%)
		zf-C5HC2	2281..2334	CDD:280996	12/55 (22%)
utx-1	NP_001309685.1	TPR_11	138..204	CDD:290150
		TPR repeat	138..168	CDD:276809
		TPR repeat	176..203	CDD:276809
		TPR repeat	271..301	CDD:276809
		TPR repeat	315..348	CDD:276809
		TPR_11	353..419	CDD:290150
		TPR repeat	353..383	CDD:276809
		TPR_1	354..387	CDD:278916
		TPR repeat	388..415	CDD:276809
		TPR	390..419	CDD:197478
		JmjC	845..909	CDD:214721	14/80 (18%)
		JmjC	879..987	CDD:202224	25/122 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900