Protein Alignment Jarid2 and rbr-2

DIOPT Version :10

• Sequence 1: NP_648324.1
• Gene: Jarid2 / 39103
• FlyBaseID: FBgn0036004
• Length: 2351
• Species: Drosophila melanogaster
• Sequence 2: NP_502032.2
• Gene: rbr-2 / 177985
• WormBaseID: WBGene00004319
• Length: 1477
• Species: Caenorhabditis elegans
• Alignment Length: 805
• Identity: 200/805 - (24%)
• Similarity: 317/805 - (39%)
• Gaps: 191/805 - (23%)

  Fly  1697 KSRTAAQTSSTAAAVAKKYKDDTPIKMAN--NTAFPRHDDPTQMVE-----------APIFRPTE 1748
            ::|....:.||.:|.:   ...:|.|.|:  |:....|....:|.:           |||:.|||
 Worm     2 RARRQENSISTPSAPS---TSTSPRKKASIGNSRSKNHGSKMEMYDQFYKKFVRPPMAPIYYPTE 63

  Fly  1749 KEFADPIEFIERITPIAARFGICKIIPPASFKPECRISDEMRFTAYNQYVHKMLHRWGPSAKELS 1813
            :||:||||::.:|...|.:||:.||:|||:|||...| |:..|| :.....|:        .|:.
 Worm    64 EEFSDPIEYVAKIRHEAEKFGVVKIVPPANFKPPFAI-DKEAFT-FRPRTQKL--------NEVE 118

  Fly  1814 AIKKYLAT-----------QSIVMNHPPWIGGMEVDLPRLYHTVQELGGLKEVIEKKKWARVAEE 1867
            ||.|...|           ..:....|....|..|||.||:..||..||.:||.|.:||..||.|
 Worm   119 AIVKEKHTFIDRLINFNRYSGLTFEFPVDRDGNIVDLYRLHRIVQNFGGCEEVNEDEKWRDVARE 183

  Fly  1868 MCIPK--LA--------------------------QDRVTKLDD--------IYCKYLLPYDTLS 1896
            . :||  :|                          :::..|.||        :..||...:.|:.
 Worm   184 Y-LPKEQMARGVPSAFINLIRSHYNLHIEPFNRNLKEKAMKNDDESDDEMEELKHKYQHHHGTMR 247

  Fly  1897 -----PAERQKLFDEVEADWAKREARAR------RNADRFVNTESVSNE----------EDDLSS 1940
                 |.::.....|.|...:.:..|.|      .::.:.:.|.|..|.          |.|...
 Worm   248 TEIEVPNDKTTEGGEDECPVSMQSGRRRSKNKKASSSRKTLGTSSKKNSTRGRKNKKKAEGDDDD 312

  Fly  1941 DED----------EESEEE-------IDGVS----------------------MECIVK------ 1960
            |||          .|.::|       |||.:                      .:||..
 Worm   313 DEDPMDQVFCVACNEGKDEDLLLLCDIDGCNNGRHTYCCDPVLDEVPEGEWRCPKCIESEDAKIG 377

  Fly  1961 --------GRSMPLSQFYRIARNTMALWFKSTD---PTVNEVEAEFWRHVAVRDSHVCVHSGS-I 2013
                    .....|:.|...|......:|...|   .:.:.||..||::|...::.|.|..|: :
 Worm   378 LDWGFYDADTEYNLNSFTEFANKWKCDYFGVKDVSQVSCDAVERSFWKNVISHENPVSVKYGADL 442

  Fly  2014 DSSGWGYGFPSPGPKGKG------SNYARHPWNLKVLTNNSGSVLRSLGP-VMGVTVPTLHVGML 2071
            .:|..|.|||....|..|      ..||.|.|||..:.....|||..... :.|:.||.::|||.
 Worm   443 ITSRVGSGFPRKEDKHTGPDLKLKQQYASHAWNLNNMPVLRESVLSHFNTGISGMMVPWVYVGMC 507

  Fly  2072 FSACCWYRDPHGLSWIEYLHTGASKLWYGIPDDQSANFRAALTSLIPTHCQNKTIWLPCDTVMVP 2136
            ||..||:.:.|....:.|.|.|..|:|||:..:.:..|..||..:.|.....:.......|....
 Worm   508 FSTFCWHTEDHWTYSVNYNHFGERKIWYGVGGEDAEKFEDALKKIAPGLTGRQRDLFHHMTTAAN 572

  Fly  2137 PHMLTDRGVSLCRIEQKPGEFIVVFPRAYTSSLATGYVVSESVYFATMSWLDLAKDDFRDIHESC 2201
            ||:|...||.:..:.|..|||::.|||||.:....|...:|:|.||.:.||...::.........
 Worm   573 PHLLRSLGVPIHSVHQNAGEFVITFPRAYHAGFNEGLNFAEAVNFAPIDWLSKGRECVESYSNVR 637

  Fly  2202 EPAMFSLEQLLF-------ALGYDQRVNSEALHQMLPMLNDVCEKESAAREQLRAAGVTSTEKVQ 2259
            ...:||.::|||       .||...   |.|.|:.|..   :.||:...||.|...||::
 Worm   638 RYLVFSHDELLFKMVEAMDKLGISM---SLATHEELIR---IYEKQKMLRELLARLGVSN----- 691

  Fly  2260 AEKGQKAKKQQQPPYKSIESE---CDLCRANLYI-SMVRTEDGNIYCLQHALKNLNNGNIQAKQC 2320
                   ::.||..::.|..|   |..|:..|:: ::|..:...:.|::|. .:|.| :...|..
 Worm   692 -------RQMQQVMFEKIPDEQRSCRFCKTTLFMCALVCNKHKKMTCVEHH-DHLCN-SCTTKDY 747

  Fly  2321 KLIYAYNVDDIQQLIRQLQEK-INH 2344
            :..|.:.:|.:..:..:|.:: :|:
 Worm   748 RYQYRFELDQLNNMCDELGKRTVNY 772

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jarid2	NP_648324.1	PHA03247	<157..429	CDD:223021
		Atrophin-1	762..>986	CDD:460830
		JmjN	1740..1781	CDD:128818	22/51 (43%)
		ARID_JARD2	1804..1915	CDD:350634	36/162 (22%)
		cupin_RmlC-like	2066..2181	CDD:477354	37/114 (32%)
		zf-C5HC2	2281..2334	CDD:460750	11/53 (21%)
rbr-2	NP_502032.2	JmjN	55..96	CDD:128818	22/40 (55%)
		BRIGHT	122..214	CDD:128777	24/92 (26%)
		PHD_SF	321..368	CDD:473978	5/46 (11%)
		JmjC	501..617	CDD:396791	37/115 (32%)
		zf-C5HC2	709..761	CDD:460750	11/53 (21%)
		PLU-1	787..1132	CDD:462475
		PHD	1208..1254	CDD:214584
		PHD3_KDM5A_like	1413..1463	CDD:277083