DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jarid2 and Jarid2

DIOPT Version :9

Sequence 1:	NP_648324.1	Gene:	Jarid2 / 39103	FlyBaseID:	FBgn0036004	Length:	2351	Species:	Drosophila melanogaster
Sequence 2:	NP_001191972.1	Gene:	Jarid2 / 16468	MGIID:	104813	Length:	1234	Species:	Mus musculus

Alignment Length:	1240	Identity:	348/1240 - (28%)
Similarity:	548/1240 - (44%)	Gaps:	255/1240 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1270 SSSSKNTRGDLGKSESAWSAKGPSLKATPVLVTPPNRKELHEQADSKDCDALDYDKSSTPVNLTQ 1334
            :.|.|...|.||.:::  .|.||:                .||::::..||.....
Mouse    53 AGSLKAVNGLLGNAQA--KALGPA----------------SEQSENEKDDASQVSS--------- 90

  Fly  1335 KITSNESLAVEKKVNDRKGKESAKAAASKAATQPRSTAATPPTPISSTPTPASLTPSKSSPTPPP 1399
              |||:..:.:.:....:.:...:|....|.:||.|.:.||...:              .|..||
Mouse    91 --TSNDVSSSDFEEGPSRKRPRLQAQRKFAQSQPNSPSTTPVKIV--------------EPLLPP 139

  Fly  1400 AVKQKAEKGKRNATAGGGAT--ALASPPAAPTPANPKRTPVY---NQKNAKAQQQQAETKPASNP 1459
            ...|.::..||........|  .|...||.|      .:.||   :|.....:::..||:.....
Mouse   140 PATQISDLSKRKPKTEDFLTFLCLRGSPALP------NSMVYFGSSQDEEDVEEEDDETEDVKAT 198

  Fly  1460 PSGAGTKRESVYAFGKDDE--------SGSKSGNRRRTDP-----SPVPAPALVPNALSERSPTK 1511
            .:.|.:..:|....||..:        :|| |.:.|..:|     |....|....:: ..|:.::
Mouse   199 TNNASSSCQSTPRKGKTHKHVHNGHVFNGS-SRSAREKEPAHKHRSKEATPGKEKHS-EPRADSR 261

  Fly  1512 KRAAAAAAATAVQLTLSPTENCKIEGKPSKAPTGRGAKKQQQQAPAPPAPPVEASGDSDAEGATF 1576
            :..|:.|..||.....|..:......:|  .|:.|.|:..::|.             |...|.|.
Mouse   262 REQASGAQPTAASAAASSAKGLAANHQP--PPSHRSAQDLRKQV-------------SKVNGVTR 311

  Fly  1577 YIPLQGAGVGGSGDGGIQGVAVKLGREGPDGPNQKVVMQATLV------TKAQMD---------- 1625
            ...| |||..          :.|..||....|::.|...||:.      |||:.:
Mouse   312 MSSL-GAGTN----------SAKKIREVRPSPSKTVKYTATVTKGTVTYTKAKRELVKETKPNHH 365

  Fly  1626 ----------------TNSKPLPESLNTNELVKTLLHAASNDAASTTTSLKSL------------ 1662
                            :|:|...:.|:.....|:...|||...||:..:.||.
Mouse   366 KPSSAVNHTISGKTESSNAKTRKQVLSLGGASKSTGPAASGLKASSRLNPKSCTKEVGGRQLREG 430

  Fly  1663 -------------------PKASTSAAAGAAAAPGASSLVRVNSNSSLFSGSAK----SRTAAQT 1704
                               |.......||.|.|||..:.. .:...||.:|..|    .|:..:.
Mouse   431 LRNSKRRLEEAQQVDKPQSPPKKMKGVAGNAEAPGKKASA-ASGEKSLLNGHVKKEVPERSLERN 494

  Fly  1705 SSTAAAVAKKY--------KDDTPIKMANNTAFPR-----HDDP------------TQMVEAPIF 1744
            ....||..|..        .:.||.: ..:|:.|.     ||..            ..|.|.|:.
Mouse   495 RPKRAAAGKNMLGKQAHGKTEGTPCE-NRSTSQPESSHKPHDPQGKPEKGSGKSGWAAMDEIPVL 558

  Fly  1745 RPTEKEFADPIEFIERITPIAARFGICKIIPPASFKPECRISDEMRFTAYNQYVHKMLHRWGPSA 1809
            ||:.|||.||:.:||.:.....::|:|::|||..::|||:::|||||....|::||:..||||:.
Mouse   559 RPSAKEFHDPLIYIESVRAQVEKYGMCRVIPPPDWRPECKLNDEMRFVTQIQHIHKLGRRWGPNV 623

  Fly  1810 KELSAIKKYLATQSIVMNHPPWIGGMEVDLPRLYHTVQELGGLKEVIEKKKWARVAEEMCIPKLA 1874
            :.|:.|||:|.:|.|.|:..|.|||.|:||...:..:.|:||:::|.:.|||.::|:.:.|||.|
Mouse   624 QRLACIKKHLRSQGITMDELPLIGGCELDLACFFRLINEMGGMQQVTDLKKWNKLADMLRIPKTA 688

  Fly  1875 QDRVTKLDDIYCKYLLPYDTLSPAERQKLFDEV------------------EADWAKREARAR-- 1919
            |||:.||.:.||:|||.||:|||.|.::|..||                  |:|..|..:..|
Mouse   689 QDRLAKLQEAYCQYLLSYDSLSPEEHRRLEKEVLMEKEILEKRKGPLEGHTESDHHKFHSLPRFE 753

  Fly  1920 -----------RNADRF----VNTESVSNEEDDLSSDEDE--ESEEEIDGVSME---CIVKGRSM 1964
                       ||..|.    |....:......|.:.|.|  :.|||..||..:   ||.||||:
Mouse   754 PKNGLVHGVTPRNGFRSKLKEVGRAPLKTGRRRLFAQEKEVVKEEEEDKGVLNDFHKCIYKGRSV 818

  Fly  1965 PLSQFYRIARNTMALWFKSTDPTVNEVEAEFWRHVAVRDSHVCVHSGSIDSSGWGYGFPSPGPKG 2029
            .|:.|||.|||.|.:.| |.:|...|:|.|:||.|..:|.||.||.|.:|::..|.||    |.|
Mouse   819 SLTTFYRTARNIMNMCF-SKEPAPAEIEQEYWRLVEEKDCHVAVHCGKVDTNTHGSGF----PVG 878

  Fly  2030 KGSNYARHPWNLKVLTNNSGSVLRSLGPVMGVTVPTLHVGMLFSACCWYRDPHGLSWIEYLHTGA 2094
            |...::||.|||.||.||:||:||.||.|.|||:|.|::||:||..||.||.:.|.:|:||||||
Mouse   879 KSEPFSRHGWNLTVLPNNTGSILRHLGAVPGVTIPWLNIGMVFSTSCWSRDQNHLPYIDYLHTGA 943

  Fly  2095 SKLWYGIPDDQSANFRAALTSLIPTHCQNKTIWLPC--DTVMVPPHMLTDRGVSLCRIEQKPGEF 2157
            ..:||.||.::.......:.:|:.   .|.|..|..  ..||:.|.:|..:|:.:.|..|:.|:|
Mouse   944 DCIWYCIPAEEENKLEDVVHTLLQ---GNGTPGLQMLESNVMISPEVLCKKGIKVHRTVQQSGQF 1005

  Fly  2158 IVVFPRAYTSSLATGYVVSESVYFATMSWLDLAKDDFRDIHESCEPAMFSLEQLLFALGYDQ--R 2220
            :|.||.::.|.:..||.|||:|:|||..|..:..:..:::........||:|:||:.:...:  :
Mouse  1006 VVCFPGSFVSKVCCGYNVSETVHFATTQWTSMGFETAKEMKRRHIAKPFSMEKLLYQIAQAEAKK 1070

  Fly  2221 VNSEALHQMLPMLNDVCEKESAAREQLRAAGVTSTEKVQAEKGQ------KAKKQQQPPYKSIES 2279
            .|...|..:..:|:::.:.|...|..|..||:.|:.:..:..|.      |.|.::....::.|.
Mouse  1071 ENGPTLSTISALLDELRDTELRQRRLLFEAGLHSSARYGSHDGNSTVADGKKKPRKWLQLETSER 1135

  Fly  2280 ECDLCRANLYISMVRTEDGN-IYCLQHALKNLNNGNIQAKQC---KLIYAYNVDDIQQLIRQLQE 2340
            .|.:|:...|:|||..|:.| ::||:.||:::.    :.|.|   ||:|.|:.:.|..|:.|:..
Mouse  1136 RCQICQHLCYLSMVVQENENVVFCLECALRHVE----KQKSCRGLKLMYRYDEEQIISLVNQICG 1196

  Fly  2341 KINHK 2345
            |::.|
Mouse  1197 KVSGK 1201

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jarid2	NP_648324.1	JmjN	1740..1781	CDD:128818	16/40 (40%)
		ARID	1812..1893	CDD:279697	37/80 (46%)
		JmjC	2066..2181	CDD:202224	44/116 (38%)
		zf-C5HC2	2281..2334	CDD:280996	19/56 (34%)
Jarid2	NP_001191972.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	68..150		12/81 (15%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:12890668	104..110		0/5 (0%)
		Sufficient for interaction with the PRC2 complex. /evidence=ECO:0000250\|UniProtKB:Q92833	141..170		7/28 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..339		38/187 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..548		60/285 (21%)
		JmjN	554..595	CDD:128818	19/40 (48%)
		ARID_JARD2	618..729	CDD:350634	45/147 (31%)
		GSGFP motif	872..876		3/3 (100%)
		JmjC	914..1029	CDD:396791	33/116 (28%)
		zf-C5HC2	1137..1190	CDD:397190
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1206..1234
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831061
Domainoid	1	1.000	114	1.000	Domainoid score	I6080
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D664180at2759
OrthoFinder	1	1.000	-	-		FOG0007182
OrthoInspector	1	1.000	-	-		oto92906
orthoMCL	1	0.900	-	-		OOG6_109452
Panther	1	1.100	-	-	O	PTHR10694
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6120
SonicParanoid	1	1.000	-	-		X5293
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.830