Protein Alignment Jarid2 and KDM5B

DIOPT Version :10

• Sequence 1: NP_648324.1
• Gene: Jarid2 / 39103
• FlyBaseID: FBgn0036004
• Length: 2351
• Species: Drosophila melanogaster
• Sequence 2: NP_001300971.1
• Gene: KDM5B / 10765
• HGNCID: 18039
• Length: 1580
• Species: Homo sapiens
• Alignment Length: 809
• Identity: 204/809 - (25%)
• Similarity: 307/809 - (37%)
• Gaps: 227/809 - (28%)

  Fly  1740 EAPIFRPTEKEFADPIEFIERITPIAARFGICKIIPPASFKP--ECRISDEMRFTAYNQYVHKML 1802
            |.|:|.|:.:|||||..||.:|.|||.:.||||:.||..::|  .|.: |::.||...|.::::.
Human    31 ECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDV-DKLHFTPRIQRLNELE 94

  Fly  1803 HRWGPSAKELSAIKKYLATQSIVMNHPPWIGGMEVDLPRLYHTVQELGGLKEVIEKKKWARVAEE 1867
            .:.......|..|.||...|...:. .|.:....:||.:|...|.|.||...|.:.:||.::|.:
Human    95 AQTRVKLNFLDQIAKYWELQGSTLK-IPHVERKILDLFQLNKLVAEEGGFAVVCKDRKWTKIATK 158

  Fly  1868 M---------------------------------CI--PKL---AQDRVTKLDDI-YCKYLLPYD 1893
            |                                 |:  |.|   .:|:..|..|| ..:.:.|.:
Human   159 MGFAPGKAVGSHIRGHYERILNPYNLFLSGDSLRCLQKPNLTTDTKDKEYKPHDIPQRQSVQPSE 223

  Fly  1894 TLSPAERQK----------------------------LFD--------------EVEADWAKREA 1916
            |..||.|.|                            |.|              ::|.: ...||
Human   224 TCPPARRAKRMRAERQSLAVLPRLECSGAILAHCNLRLLDSSNSSASASQAMNIKIEPE-ETTEA 287

  Fly  1917 RARRNADRF-VNTESVSNEEDDLSSDEDE---------ESEEE---------------------- 1949
            |......|. ..|....||::..||.:.|         |:|:|
Human   288 RTHNLRRRMGCPTPKCENEKEMKSSIKQEPIERKDYIVENEKEKPKSRSKKATNAVDLYVCLLCG 352

  Fly  1950 ----------IDGVS----------------------MECIVKGRSMPLSQ--FYRIARN----- 1975
                      .||..                      .:|:.:..|.|...  |.:.||:
Human   353 SGNDEDRLLLCDGCDDSYHTFCLIPPLHDVPKGDWRCPKCLAQECSKPQEAFGFEQAARDYTLRT 417

  Fly  1976 --TMALWFKS--------TDPTVNEVEAEFWRHVAVRDSHVCVHSGS-IDSSGWGYGFPSPGPKG 2029
              .||..|||        ..|| ..||.||||.|:..:..|.|..|: |.|..:|.|||....|.
Human   418 FGEMADAFKSDYFNMPVHMVPT-ELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRDGKI 481

  Fly  2030 KGS----NYARHPWNLKVLTNNSGSVLRSL-GPVMGVTVPTLHVGMLFSACCWYRDPHGLSWIEY 2089
            |.|    .|....|||..:.....|||..: ..:.|:.:|.|:|||.||:.||:.:.|....|.|
Human   482 KLSPEEEEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDHWSYSINY 546

  Fly  2090 LHTGASKLWYGIPDDQSANFRAALTSLIPTHCQNKTIWLPCDTVMVPPHMLTDRGVSLCRIEQKP 2154
            ||.|..|.|||:|...:......:..|.|....::...|.....::.|:.|....|.:.|..|..
Human   547 LHWGEPKTWYGVPGYAAEQLENVMKKLAPELFVSQPDLLHQLVTIMNPNTLMTHEVPVYRTNQCA 611

  Fly  2155 GEFIVVFPRAYTSSLATGYVVSESVYFATMSWLDLAK---DDFRDIHESCEPAMFSLEQLLFALG 2216
            |||::.|||||.|....|:..:|:|.|.|:.||.|.:   :.:|.:|..|   :||.::::..:.
Human   612 GEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVEHYRLLHRYC---VFSHDEMICKMA 673

  Fly  2217 -----YDQRVNSEALHQMLPMLNDVCEKESAAREQLRAAGVTSTEKVQAEKGQKAKKQQQPPYKS 2276
                 .|..|.|.....|..|:.|    |.|.||.:|..||..:|::..|.           ...
Human   674 SKADVLDVVVASTVQKDMAIMIED----EKALRETVRKLGVIDSERMDFEL-----------LPD 723

  Fly  2277 IESECDLCRANLYISMV--RTEDGNIYCLQHALKNLNNGNIQAKQC-----KLIYAYNVDDIQQL 2334
            .|.:|..|:...::|.:  ..:.|.:.||.| :|.|.:       |     ||.|.|.:||:..:
Human   724 DERQCVKCKTTCFMSAISCSCKPGLLVCLHH-VKELCS-------CPPYKYKLRYRYTLDDLYPM 780

  Fly  2335 IRQLQ---EKINH---------KAAVKKK 2351
            :..|:   |..|.         :|.:.||
Human   781 MNALKLRAESYNEWALNVNEALEAKINKK 809

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jarid2	NP_648324.1	PHA03247	<157..429	CDD:223021
		Atrophin-1	762..>986	CDD:460830
		JmjN	1740..1781	CDD:128818	21/40 (53%)
		ARID_JARD2	1804..1915	CDD:350634	34/191 (18%)
		cupin_RmlC-like	2066..2181	CDD:477354	39/114 (34%)
		zf-C5HC2	2281..2334	CDD:460750	16/59 (27%)
KDM5B	NP_001300971.1	JmjN	31..72	CDD:128818	21/40 (53%)
		ARID_KDM5B	94..183	CDD:350638	18/89 (20%)
		PHD1_KDM5B	347..392	CDD:277076	2/44 (5%)
		JmjC	522..638	CDD:396791	39/115 (34%)
		zf-C5HC2	728..780	CDD:460750	16/59 (27%)
		PLU-1	793..1124	CDD:462475	3/17 (18%)
		PHD2_KDM5B	1214..1257	CDD:277080
		PHD3_KDM5B	1522..1571	CDD:277157