DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jarid2 and kdm5a

DIOPT Version :9

Sequence 1:	NP_648324.1	Gene:	Jarid2 / 39103	FlyBaseID:	FBgn0036004	Length:	2351	Species:	Drosophila melanogaster
Sequence 2:	XP_017209947.2	Gene:	kdm5a / 100333310	ZFINID:	ZDB-GENE-150114-1	Length:	1663	Species:	Danio rerio

Alignment Length:	705	Identity:	174/705 - (24%)
Similarity:	276/705 - (39%)	Gaps:	175/705 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1740 EAPIFRPTEKEFADPIEFIERITPIAARFGICKIIPPASFKP--ECRISDEMRFTAYNQYVHKML 1802
            |.|:|.|:.::|:||..||.:|..||...|||||.||..::|  .|.:. ..|||...|.::::.
Zfish    12 ECPVFEPSWQDFSDPFSFIHKIREIAENTGICKIRPPQGWQPPFACDVR-SFRFTPRVQRLNELE 75

  Fly  1803 HRWGPSAKELSAIKKYLATQSIVMNHPPWIGGMEVDLPRLYHTVQELGGLKEVIEKKKWARVAEE 1867
            .........|..:.::...|...: ..|.:....:||..|...|...||.:.|.::|:|::::..
Zfish    76 ALTRVKLNFLDQLSRFWELQGCRL-RIPHVERRVLDLYLLSKLVSAEGGFELVCKEKRWSKISSR 139

  Fly  1868 MCIPKLAQDRVTKLDDIYCKYLLPYDTLSP----------------------AERQKLFDEVEAD 1910
            :..|. .:...:.|...:.:.|.||:....                      |..::..||.|
Zfish   140 LGFPS-GRAVGSLLRQHHERILYPYELFQSGASLTGVYPDSADSDSVDEGIGAADEEAVDEEE-- 201

  Fly  1911 WAKREARARRNADRFVNTESVSNEE-------DDLSSDE-------------------------- 1942
              ::|.||.|.:.|....:...|.|       |.:|:|:
Zfish   202 --EKERRAERRSPRHRLKDERENTEPRGVPVLDVISADDEAFLRKQKHLKAQAFALKMRPRKEVL 264

  Fly  1943 ----------------DEESE--------------------EEI---DGVSMECIVKGRSMPLSQ 1968
                            |||..                    :::   |....:|:.:..|.|...
Zfish   265 EVNYIDLYMCMACGRGDEEDRLLLCDGCDDSCHTFCLIPPLQDVPRGDWRCPKCVAEECSKPREA 329

  Fly  1969 F--------YRI-ARNTMALWFKS--------TDPTVNEVEAEFWRHVAVRDSHVCVHSGS-IDS 2015
            |        |.: :...||..|||        ..|| ..||.||||.|:..|..|.|..|: |.|
Zfish   330 FGFEQAVREYTLQSFGEMADHFKSDYFNMPVHMVPT-ELVEKEFWRLVSSIDEDVIVEYGADISS 393

  Fly  2016 SGWGYGFPSPGPK----GKGSNYARHPWNLK--------VLTNNSGSVLRSLGPVMGVTVPTLHV 2068
            ...|.|||....:    |....||...|||.        |||:.||.       :.|:.||.|:|
Zfish   394 KDVGSGFPVRDGRRKLIGDEEEYAASGWNLNNLPVLEQCVLTHTSGD-------ISGMKVPWLYV 451

  Fly  2069 GMLFSACCWYRDPHGLSWIEYLHTGASKLWYGIPDDQSANFRAALTSLIPTHCQNKTIWLPCDTV 2133
            ||.||:.||:.:.|..|.|.|||.|..|.|||:|...:......:..:.|....::...|.....
Zfish   452 GMCFSSFCWHIEDHWSSSINYLHWGEPKTWYGVPARAAEQLECVMKKVAPELFDSQPDLLHQLVT 516

  Fly  2134 MVPPHMLTDRGVSLCRIEQKPGEFIVVFPRAYTSSLATGYVVSESVYFATMSWLDLAK---DDFR 2195
            ::.|::|.:.||.:.|..|..|||::.|||||.|....||..:|:|.|.|..||.:.:   ..:|
Zfish   517 LMNPNVLMEHGVPVYRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVSHYR 581

  Fly  2196 DIHESCEPAMFSLEQLLFAL-----GYDQRVNSEALHQMLPMLNDVCEKESAAREQLRAAGVTST 2255
            .:...|   :||.|:|:..:     |.|..:.:.|:.:    |.::.|:|:..|..|...||.|:
Zfish   582 RLQRYC---VFSHEELVCKMAADPEGLDVELAAAAVRE----LEELLEEETRLRSALEETGVISS 639

  Fly  2256 EKVQAEKGQKAKKQQQPPYKSI---ESECDLCRANLYISMV--RTEDGNIYCLQH 2305
                          .|..::.:   |.:|..|:...::|.|  ......:.||:|
Zfish   640 --------------VQEVFELLPDDERQCWSCKTTCFLSAVTCSCSPERLVCLRH 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jarid2	NP_648324.1	JmjN	1740..1781	CDD:128818	19/40 (48%)
		ARID	1812..1893	CDD:279697	16/80 (20%)
		JmjC	2066..2181	CDD:202224	41/114 (36%)
		zf-C5HC2	2281..2334	CDD:280996	7/27 (26%)
kdm5a	XP_017209947.2	JmjN	12..53	CDD:128818	19/40 (48%)
		ARID	79..164	CDD:198082	16/86 (19%)
		PHD1_KDM5A_like	274..318	CDD:276990	4/43 (9%)
		JmjC	448..564	CDD:202224	41/115 (36%)
		zf-C5HC2	654..706	CDD:308530	7/27 (26%)
		PLU-1	719..1051	CDD:312061
		PHD2_KDM5A	1142..1197	CDD:277079
		PHD3_KDM5A	1584..1635	CDD:277156
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D664180at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10694
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.020