DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Uch-L5 and Uchl5

DIOPT Version :9

Sequence 1:	NP_001261632.1	Gene:	Uch-L5 / 39102	FlyBaseID:	FBgn0011327	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_062508.2	Gene:	Uchl5 / 56207	MGIID:	1914848	Length:	329	Species:	Mus musculus

Alignment Length:	333	Identity:	201/333 - (60%)
Similarity:	252/333 - (75%)	Gaps:	15/333 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGDGAGNWCLIESDPGVFTELIREFGCDGAQVEEIWSLDSESFKNLEPIHGLIFLFKWVQEDEPA 65
            |...||.|||:|||||||||||:.|||.||||||||||:.|||:.|:|:|||||||||...:|||
Mouse     1 MSSNAGEWCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPESFEKLKPVHGLIFLFKWQPGEEPA 65

  Fly    66 GKVVLDR--ENIFFAKQVINNACATQAILSLLMNLDHEDIKLGETLTNFKEFCQCFDPYNKGLTL 128
            |.||.|.  |.|||||||||||||||||:|:|:|..|:|:.|||||:.||||.|.||...|||.|
Mouse    66 GSVVQDSRLETIFFAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLAL 130

  Fly   129 SNASQIRTVHNSFARPTLFELDTKNQKKDDDVYHFVGYMPIGGRLYELDGLREGPIDLGEIKSEQ 193
            ||:..||.|||||||..:||.|||...|::|.:|||.|:|:.|||||||||||||||||.. ::.
Mouse   131 SNSDVIRQVHNSFARQQMFEFDTKTPAKEEDAFHFVSYVPVNGRLYELDGLREGPIDLGAC-NQD 194

  Fly   194 NWIDVVRPIIEKRMQRYSDGEIHFNLMALISDRQRIYEQQIEKLLN--PAPNAMDTEEDR----- 251
            :||..|||:||||:|:||:|||.|||||::|||:.||||:|.:|..  .....|||::..
Mouse   195 DWITAVRPVIEKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQLAEEEPMDTDQGSTVLSA 259

  Fly   252 -QAEISSLRTYIEYEIQKKKRYKVENVRRKHNYLPFIVELLKILGENGQLMPIYEKAKQRALERE 315
             |:|::..:..||.|:||.||||:||:||||||||||:||||.|.|:.||:|:.||||    |::
Mouse   260 IQSEVARNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKAK----EKQ 320

  Fly   316 QAQRKKDT 323
            .|::.::|
Mouse   321 NAKKAQET 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uch-L5	NP_001261632.1	Peptidase_C12_UCH37_BAP1	8..222	CDD:187738	146/215 (68%)
Uchl5	NP_062508.2	Peptidase_C12	8..223	CDD:187736	146/215 (68%)
		UCH_C	264..309	CDD:375501	27/44 (61%)
		Interaction with ADRM1. /evidence=ECO:0000250	313..329		7/20 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849800
Domainoid	1	1.000	284	1.000	Domainoid score	I1630
eggNOG	1	0.900	-	-		E1_KOG2778
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9326
Inparanoid	1	1.050	401	1.000	Inparanoid score	I1922
Isobase	1	0.950	-	0	Normalized mean entropy	S1802
OMA	1	1.010	-	-		QHG53985
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001783
OrthoInspector	1	1.000	-	-		oto93236
orthoMCL	1	0.900	-	-		OOG6_102753
Panther	1	1.100	-	-	LDO	PTHR10589
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1589
SonicParanoid	1	1.000	-	-		X1137
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740