DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Uch-L5 and UCHL5

DIOPT Version :9

Sequence 1:	NP_001261632.1	Gene:	Uch-L5 / 39102	FlyBaseID:	FBgn0011327	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	XP_006711430.1	Gene:	UCHL5 / 51377	HGNCID:	19678	Length:	421	Species:	Homo sapiens

Alignment Length:	343	Identity:	194/343 - (56%)
Similarity:	241/343 - (70%)	Gaps:	38/343 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGDGAGNWCLIESDPGVFTELIREFGCDGAQVEEIWSLDSESFKNLEPIHGLIFLFKWVQEDEPA 65
            |...||.|||:|||||||||||:.|||.||||||||||:.|:|:.|:|:|||||||||...:|||
Human    68 MTGNAGEWCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPENFEKLKPVHGLIFLFKWQPGEEPA 132

  Fly    66 GKVVLDR--ENIFFAKQVINNACATQAILSLLMNLDHEDIKLGETLTNFKEFCQCFDPYNKGLTL 128
            |.||.|.  :.|||||||||||||||||:|:|:|..|:|:.|||||:.||||.|.||...|||.|
Human   133 GSVVQDSRLDTIFFAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLAL 197

  Fly   129 SNASQIRTVHNSFARPTLFELDTKNQKKDDDVYHFVGYMPIGGRLYELDGLREGPIDLGEIKSEQ 193
            ||:..||.|||||||..:||.|||...|::|.:|||.|:|:.|||||||||||||||||.. ::.
Human   198 SNSDVIRQVHNSFARQQMFEFDTKTSAKEEDAFHFVSYVPVNGRLYELDGLREGPIDLGAC-NQD 261

  Fly   194 NWIDVVRPIIEKRMQR---------------------------YSDGEIHFNLMALISDRQRIYE 231
            :||..|||:||||:|:                           ||:|||.|||||::|||:.|||
Human   262 DWISAVRPVIEKRIQKDGFSPCCPGWSQTPELKPSACLDLPKWYSEGEIRFNLMAIVSDRKMIYE 326

  Fly   232 QQIEKLLN--PAPNAMDTEEDR------QAEISSLRTYIEYEIQKKKRYKVENVRRKHNYLPFIV 288
            |:|.:|..  .....|||::..      |:|::..:..||.|:||.||||:||:||||||||||:
Human   327 QKIAELQRQLAEEEPMDTDQGNSMLSAIQSEVAKNQMLIEEEVQKLKRYKIENIRRKHNYLPFIM 391

  Fly   289 ELLKILGENGQLMPIYEK 306
            ||||.|.|:.||:|:.||
Human   392 ELLKTLAEHQQLIPLVEK 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uch-L5	NP_001261632.1	Peptidase_C12_UCH37_BAP1	8..222	CDD:187738	144/242 (60%)
UCHL5	XP_006711430.1	Peptidase_C12	75..317	CDD:187736	144/242 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159431
Domainoid	1	1.000	283	1.000	Domainoid score	I1655
eggNOG	1	0.900	-	-		E1_KOG2778
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9326
Inparanoid	1	1.050	399	1.000	Inparanoid score	I1947
Isobase	1	0.950	-	0	Normalized mean entropy	S1802
OMA	1	1.010	-	-		QHG53985
OrthoDB	1	1.010	-	-		D1363547at2759
OrthoFinder	1	1.000	-	-		FOG0001783
OrthoInspector	1	1.000	-	-		oto89667
orthoMCL	1	0.900	-	-		OOG6_102753
Panther	1	1.100	-	-	LDO	PTHR10589
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1589
SonicParanoid	1	1.000	-	-		X1137
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750