DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Uch-L5 and Bap1

DIOPT Version :9

Sequence 1:	NP_001261632.1	Gene:	Uch-L5 / 39102	FlyBaseID:	FBgn0011327	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_001100762.1	Gene:	Bap1 / 306257	RGDID:	1311938	Length:	740	Species:	Rattus norvegicus

Alignment Length:	287	Identity:	108/287 - (37%)
Similarity:	157/287 - (54%)	Gaps:	47/287 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 WCLIESDPGVFTELIREF-------------GCDGAQVEEIWSLDSESFKNLEPIHGLIFLFKWV 59
            |..:|||||:||.|:.:|             |..|.|||||:.|.|   |...|::|.||||||:
  Rat     5 WLELESDPGLFTLLVEDFGKNPFTPDRRALAGVKGVQVEEIYDLQS---KCQGPVYGFIFLFKWI 66

  Fly    60 QEDEPAGKV--------VLDRE---NIFFAKQVINNACATQAILSLLMNLDHEDIKLGETLTNFK 113
            :|.....||        |:|.:   ::|||.|:|.|:|||.|:||:|:|..:.|  ||.||:..|
  Rat    67 EERRSRRKVSTLVDDTSVIDDDIVNSMFFAHQLIPNSCATHALLSVLLNCSNVD--LGPTLSRMK 129

  Fly   114 EFCQCFDPYNKGLTLSNASQIRTVHNSFARPTLFELDTK----NQKKDDDVYHFVGYMPIGGRLY 174
            :|.:.|.|.:||..:.||.::...|||.|||....|..|    :..:..:.:|||.|:||.|||:
  Rat   130 DFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRLF 194

  Fly   175 ELDGLREGPIDLGEIKSEQNWIDVVRPIIEKRMQRYSDGE----IHFNLMALISDRQRIYEQQIE 235
            |||||:..|||.|....::.|.|..|.:|.:|:...:.||    |.|||||::.||:..||.::.
  Rat   195 ELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRVKYEARLH 259

  Fly   236 KLLNPAPNAMDTEEDRQAEISSLRTYI 262
            .|          :.:||..:.:|:..|
  Rat   260 VL----------KGNRQTVLEALQQLI 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uch-L5	NP_001261632.1	Peptidase_C12_UCH37_BAP1	8..222	CDD:187738	98/245 (40%)
Bap1	NP_001100762.1	Peptidase_C12_UCH37_BAP1	5..246	CDD:187738	98/245 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	286..364
		HBM-like motif. /evidence=ECO:0000250\|UniProtKB:Q92560	376..379
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..448
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..535
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	586..635
		Interaction with BRCA1. /evidence=ECO:0000250	607..732
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	715..740
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q92560	728..733
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2778
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1363547at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820