DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Uch-L5 and ubh-4

DIOPT Version :9

Sequence 1:	NP_001261632.1	Gene:	Uch-L5 / 39102	FlyBaseID:	FBgn0011327	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_001379065.1	Gene:	ubh-4 / 174289	WormBaseID:	WBGene00006724	Length:	321	Species:	Caenorhabditis elegans

Alignment Length:	320	Identity:	161/320 - (50%)
Similarity:	226/320 - (70%)	Gaps:	12/320 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 AGNWCLIESDPGVFTELIREFGCDGAQVEEIWSLDSESFKNLEPIHGLIFLFKWVQEDEPAGKVV 69
            ||:|||||||||||||::|.||.||.||||::|||.:.... .|.:||||||||.|.||..| :.
Worm     4 AGSWCLIESDPGVFTEMLRGFGVDGLQVEELYSLDDDKAMT-RPTYGLIFLFKWRQGDETTG-IP 66

  Fly    70 LDRENIFFAKQVINNACATQAILSLLMNLDHEDIKLGETLTNFKEFCQCFDPYNKGLTLSNASQI 134
            .|::|||||.|.|.|||||||:::||||::..|:|||..|..:|||....||..:|..|||:.:|
Worm    67 SDKQNIFFAHQTIQNACATQALINLLMNVEDTDVKLGNILNQYKEFAIDLDPNTRGHCLSNSEEI 131

  Fly   135 RTVHNSFARPTLFELDTKNQKKDDDVYHFVGYMPIGGRLYELDGLREGPIDLGEIKSEQNWIDVV 199
            |||||||:|.||||||.|..:.:|: ||||.|:|||.::||||||||.|:::.|.:.||:||:.:
Worm   132 RTVHNSFSRQTLFELDIKGGESEDN-YHFVTYVPIGNKVYELDGLRELPLEVAEFQKEQDWIEAI 195

  Fly   200 RPIIEKRMQRYSDGEIHFNLMALISDRQRIYEQQIEKLLNPAPNAMDTEEDRQAEISSLRTYIEY 264
            :|:|::|||:||:|||.||||||:.:|::..::.:|.|:....|     .:.:.:|:.|...|..
Worm   196 KPVIQQRMQKYSEGEITFNLMALVPNRKQKLQEMMENLIQANEN-----NELEEQIADLNKAIAD 255

  Fly   265 EIQKKKRYKVENVRRKHNYLPFIVELLKILGENGQLMPIYEKAKQRALEREQAQRKKDTD 324
            |..|.:.|:.||.||:|||.||::||:|||.:.|:|:.:.:.|.|.|.|:.    |.:||
Worm   256 EDYKMEMYRKENNRRRHNYTPFVIELMKILAKEGKLVGLVDNAYQAAKEKS----KLNTD 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uch-L5	NP_001261632.1	Peptidase_C12_UCH37_BAP1	8..222	CDD:187738	124/213 (58%)
ubh-4	NP_001379065.1	Peptidase_C12_UCH37_BAP1	7..218	CDD:187738	124/213 (58%)
ubh-4	NP_001379065.1	UCH_C	246..291	CDD:407868	21/44 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167044
Domainoid	1	1.000	241	1.000	Domainoid score	I1247
eggNOG	1	0.900	-	-		E1_KOG2778
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9326
Inparanoid	1	1.050	322	1.000	Inparanoid score	I1477
Isobase	1	0.950	-	0	Normalized mean entropy	S1802
OMA	1	1.010	-	-		QHG53985
OrthoDB	1	1.010	-	-		D1363547at2759
OrthoFinder	1	1.000	-	-		FOG0001783
OrthoInspector	1	1.000	-	-		otm14336
orthoMCL	1	0.900	-	-		OOG6_102753
Panther	1	1.100	-	-	LDO	PTHR10589
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1589
SonicParanoid	1	1.000	-	-		X1137
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750