DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Uch-L5 and Bap1

DIOPT Version :9

Sequence 1:	NP_001261632.1	Gene:	Uch-L5 / 39102	FlyBaseID:	FBgn0011327	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_081364.1	Gene:	Bap1 / 104416	MGIID:	1206586	Length:	728	Species:	Mus musculus

Alignment Length:	274	Identity:	109/274 - (39%)
Similarity:	157/274 - (57%)	Gaps:	34/274 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 WCLIESDPGVFTELIREFGCDGAQVEEIWSLDSESFKNLEPIHGLIFLFKWVQEDEPAGKV---- 68
            |..:|||||:||.|:.:||..|.|||||:.|.|   |...|::|.||||||::|.....||
Mouse     5 WLELESDPGLFTLLVEDFGVKGVQVEEIYDLQS---KCQGPVYGFIFLFKWIEERRSRRKVSTLV 66

  Fly    69 ----VLDRE---NIFFAKQVINNACATQAILSLLMNLDHEDIKLGETLTNFKEFCQCFDPYNKGL 126
                |:|.:   |:|||.|:|.|:|||.|:||:|:|..:.|  ||.||:..|:|.:.|.|.:||.
Mouse    67 DDTSVIDDDIVNNMFFAHQLIPNSCATHALLSVLLNCSNVD--LGPTLSRMKDFTKGFSPESKGY 129

  Fly   127 TLSNASQIRTVHNSFARPTLFELDTK----NQKKDDDVYHFVGYMPIGGRLYELDGLREGPIDLG 187
            .:.||.::...|||.|||....|..|    :..:..:.:|||.|:||.|||:|||||:..|||.|
Mouse   130 AIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRLFELDGLKVYPIDHG 194

  Fly   188 EIKSEQNWIDVVRPIIEKRMQRYSDGE----IHFNLMALISDRQRIYEQQIEKLLNPAPNAMDTE 248
            ....::.|.|..|.:|.:|:...:.||    |.|||||::.||:..||.::..|          :
Mouse   195 PWGEDEEWTDKARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRIKYETRLHVL----------K 249

  Fly   249 EDRQAEISSLRTYI 262
            .:||..:.:|:..|
Mouse   250 VNRQTVLEALQQLI 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uch-L5	NP_001261632.1	Peptidase_C12_UCH37_BAP1	8..222	CDD:187738	99/232 (43%)
Bap1	NP_081364.1	Peptidase_C12_UCH37_BAP1	5..233	CDD:187738	99/232 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	273..333
		HBM-like motif. /evidence=ECO:0000250\|UniProtKB:Q92560	363..366
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	372..436
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	463..523
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..623
		Interaction with BRCA1. /evidence=ECO:0000250	595..720
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	702..728
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q92560	716..721
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2778
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1363547at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820