DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LAMA4 and wb

DIOPT Version :9

Sequence 1:NP_001098676.2 Gene:LAMA4 / 3910 HGNCID:6484 Length:1823 Species:Homo sapiens
Sequence 2:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster


Alignment Length:1938 Identity:462/1938 - (23%)
Similarity:760/1938 - (39%) Gaps:459/1938 - (23%)


- Green bases have known domain annotations that are detailed below.


Human    71 FFHTLSGECVPCDCNGNSNECLDGSGYCVHCQRNTTGEHCEKCLDGYIGDSIRGAPQFCQPCPCP 135
            |...|.|...||.|||.|::|...:|.|.:|:.||.|:||.:|.:|:.||.  .:|..||.||||
  Fly  1659 FIEDLIGRAAPCHCNGRSSDCDRETGVCQNCRGNTGGDHCHQCAEGFYGDP--NSPHGCQACPCP 1721

Human   136 LPHLANFAESCYRKNGAVRCICNENYAGPNCERCAPGYYGNPLLI-GSTCKKCDCSGNSDPNLIF 199
            ..: .|||..|...:|.|.|:|...|.|..||||..||:|:|:.. .:||:.|:|..:   .:..
  Fly  1722 ETN-RNFARGCNVWDGEVSCVCKPGYTGRLCERCQAGYFGDPMRYPNTTCQPCNCHPD---GIQT 1782

Human   200 EDCDEVTGQCRNCLRNTTGFKCERC-APGYYGDARIAKNCAVCNCGGGPCDSVTGECLEEGFEPP 263
            |.||..||:| .|....||.||::| |..::   .:...|.:                       
  Fly  1783 EGCDVETGRC-YCREGVTGLKCDKCQAERHH---LVDNGCKI----------------------- 1820

Human   264 TGMDCPTISCDKCVWDLTDDLRLAALSIEEGKSGVLSVSSGAAAHRHVNEINATIYLLKTKLSER 328
                     ||.|...|.|.:.|....:..|... :.::...|.:|              ||||.
  Fly  1821 ---------CDNCTLLLLDYMELVGNKLRRGMHN-MDLTGIPAPYR--------------KLSEY 1861

Human   329 ENQY------------ALRKIQINNAENTMKSLLSDVEELVEKENQASRKG-QLVQKESMDTINH 380
            |:.|            ..|::|..::.:.:|     :|...|.....|||. ..:.|......:.
  Fly  1862 ESAYEKWNGRHWDFSQTKRRLQDYDSADILK-----LEAHAENLKFQSRKAVATIGKREFAIKSM 1921

Human   381 ASQLVEQAHD---MRDKIQEINNKMLYYGEE-HELS-PKEISEKLVLAQ------KMLEEIRSR- 433
            ....|.|.|.   :|.:|.:..:.:..||:. |.|| |..:.:.....|      :|::.|||. 
  Fly  1922 REDAVTQQHSVGLLRSEILQTLSDLHGYGKSAHYLSLPTALKQARFYLQAIREHDQMVQGIRSTN 1986

Human   434 ----QPFFTQRELVDEEADEA--YELLSQAESWQRLHNETRTLFPVVLEQLDDYNAKLSDLQEAL 492
                :.|:......|...||:  .|:|     |:.| |:|              |.::.|::..:
  Fly  1987 DCAWKHFYAMGNASDASFDESGRLEML-----WRDL-NQT--------------NHRVVDMRLQV 2031

Human   493 DQALNYVRDAED-MNRATAARQRDHEKQQERVREQMEVVNMSLSTSADSLTTP----------RL 546
            |:......:||| :........|..|..||     ::.:|..:|...|    |          ||
  Fly  2032 DRVQEVENEAEDVLEHVRNLSIRVGESHQE-----LDELNQRISDHLD----PGYLEQGEGLLRL 2087

Human   547 TLSELDDIIKNASGIYAEIDGAK----SELQVKLSNLSNLSHDLVQEAIDHAQDLQQEANELSRK 607
            |:..  .|:.|  |...::||.:    :.|.||......:....:.:|..||..|...:||.:||
  Fly  2088 TVQR--QIMLN--GHLNQLDGYRILLNTTLGVKTEQQREVRKHWLPKAEKHASHLLARSNEYARK 2148

Human   608 LHSSDMNGLVQKALDASNVYENIVNYVSEANETAEFALNTTDRIYDAVSGIDTQIIYHKDES--- 669
            ...: .|| .:.|:.||:.:.||...:::|...:..|   .:|:|:|     .:.:|..|.|   
  Fly  2149 FQPT-RNG-ARIAMLASSAHSNITEAINDARLASILA---KERVYEA-----QRTLYPSDGSSMI 2203

Human   670 ---ENLLNQARELQAKA--ESSSDEAVADTSRR----VGG--ALARKSALKTRLSDAVKQLQAAE 723
               ::.|:::::||.:|  :......:.|...|    |.|  :....|.|:|  ::...|||...
  Fly  2204 ERAKHSLHRSKQLQQEALKQMHKSNVLKDKLHRQEQQVEGIKSTIYDSGLRT--NNISGQLQGLS 2266

Human   724 RGDAQQRLGQSRLITEEANRT----------TMEVQQATAPMANNLTN----WSQNLQHFDSSAY 774
            .|.|::   |::...|.|:||          ..::|::...|.|:.:|    |...|.....:..
  Fly  2267 DGSARR---QAKDSLEMADRTGEQMRAELQKAKDMQKSIQNMRNSFSNLEPDWEIKLGMAQENIS 2328

Human   775 NTAVNSARDAVRNLTEVVPQLLDQLRTVEQKRPA---SNVSASIQRIRELIAQTRSVASKIQVSM 836
            .|..|      ..|..|....|:|....||:...   ::::..:|::|:.||:.|..|..|.||:
  Fly  2329 LTQTN------LRLANVSLSYLEQQAEKEQQVFEVWNNSMAQQLQQLRDQIAKARHAAEAIDVSL 2387

Human   837 MFDGQSAVEVHSRTSMDDLKAFTSLSLYMKPPVKRPELTETADQFILYLGSKNAKKEYMGLAIKN 901
            ...|...:..:       |.|...||...|..:............:::|.|...:  ::.|.:..
  Fly  2388 ESLGPKCIRSY-------LPASYGLSTSNKIRMSFALSNHLESSPLIHLASSEGR--HITLELYK 2443

Human   902 DNLVYVYNLG--TKDVEIPL-----DSKPVSSWPAYFSIVKIERVGKHGKVFLTVPSLSSTAEEK 959
            ..:..|:|||  |..|..|:     |.|...:|             .|.:...|: :|.|....:
  Fly  2444 RRVRLVWNLGGTTATVTHPMVVHTRDPKYDDAW-------------YHVEANRTL-NLGSLVVRR 2494

Human   960 FIKKGEFSGDDSLL---DLDPEDTVFY--------VGGVPSNFKLPTSLNLPGFVGCLELATLNN 1013
            ....||.:..:.::   ..|.|.|.||        :||..|.....|    ||....:....::|
  Fly  2495 MNNYGELTPPNPVIITGSTDTEHTRFYQSRSDRISLGGFASKDLQFT----PGLNVVVHQVEVDN 2555

Human  1014 DVISLYNFKHIYNMDPSTSVPCARDKLAFTQSRAAS--YFFDGSGYAVVRDI----TRRGKFGQV 1072
            ..:.|:||       .::...|....:...:|.|:|  ..|:|.|||.:...    ||:..|...
  Fly  2556 KPLGLWNF-------VTSEGSCGGSMVGAKESSASSTARHFNGLGYAQLMKTRPRPTRKNLFSVQ 2613

Human  1073 TRFDIEVRTPADNGLILLMVN-------------GSMFFRLEMRNGYLHVFYDFGFSGGPVHLED 1124
            ..|    ||..:|.|:.|.|:             |.:.||:           |:|..        
  Fly  2614 MTF----RTLDENALLFLAVDDKNNRSVSVTLSRGRIMFRI-----------DYGDE-------- 2655

Human  1125 TLKKAQINDAKYH------------EISIIYHNDKKMILVVDRRHVKSMDNEKMKIPF------T 1171
              .|.:||..|.:            |.|.....:..|:.|.:.|.:.......:.|..      |
  Fly  2656 --SKLEINTTKKYNVGQWIKIEAAREFSAKRSTENGMLRVNNDRPISGAPTLPVNIHLLPDLSKT 2718

Human  1172 DIYIGGAPPEILQ--SRALRAHLPLDINFRGCMKGFQFQKKDFNLLEQTETLGVGYGCPEDSLIS 1234
            ..|:||.||....  |:|..|..|    |.||||..|...:.::.||.:...||...|  .::|:
  Fly  2719 VYYLGGVPPGFTSGTSKAPGADNP----FLGCMKDVQVNGETYDPLESSSYYGVEPSC--KNMIT 2777

Human  1235 RRAYFNGQSFI----ASIQKISFFDGFEGGFNFRTLQPNGLLFYYASGSDV------------FS 1283
             :|.|:|..::    .|::|.|     .....||||||:.||...|...::            ||
  Fly  2778 -KAGFSGNGYLELPSQSLRKRS-----NTALVFRTLQPDCLLLLAAYPPEILGDYDAKDIKGNFS 2836

Human  1284 ISLDNGTVIMDVKG----IKVQSVDKQYNDGLSHFVISSVSPTRYELIVD----KSRVGSKNPTK 1340
            |||.:|.:.:.|..    ||:.|...|.|||..|.|....:..:.||:||    :.|..:.|||.
  Fly  2837 ISLVDGQLHVWVNSGRSFIKMSSNSSQMNDGEFHVVHLIKTGRKLELMVDDELQEIRNLNGNPTV 2901

Human  1341 GKIEQTQASEKKFYFGG-------SPISAQYANFTGCISNAYFTRVDRDVEVEDFQRYTE----- 1393
            ..:.:....   .|.||       :|::..:.|..|.|.:..|.  :|.:...|...:..     
  Fly  2902 VSLPRDAGG---LYIGGAPPHESYTPLAPTFVNLEGAIRDVVFN--NRTINFNDALTFANVQIGR 2961

Human  1394 ------KVHTSLYECPIESSPLFLLHKKGKNLSKPKASQNKKGGKSKDAPSWDPVA--------- 1443
                  .:...||:..:::.|:.     ||:.     :.:.:|.|...:.|::|.|         
  Fly  2962 NGPLMGSLKGGLYDVLLKTEPMI-----GKSF-----TASPEGCKRIGSYSYEPNAFKFGDDIYS 3016

Human  1444 ---LKLPERNTPRNSHCHLSNSPRAIEHAYQYGGTANSRQEFEHLKGDFGAKSQFSIRLRTRSSH 1505
               ||||||                  |.:|        :.| ||..||          |:...:
  Fly  3017 YSQLKLPER------------------HFWQ--------RNF-HLSFDF----------RSFYPN 3044

Human  1506 GMIFYV--SDQEENDFMTLFLAHGRLVYMFNVGHKKLKIRSQEKYNDGLWHDV-IFIRERSSGRL 1567
            ||::..  |.::...::.|.|..|:||.:.. |.::.:::...|.|||.||.| |...:|.....
  Fly  3045 GMLYLSPGSKEKPKHYVALVLKDGQLVLVVR-GRRREELQLTAKLNDGEWHRVTISCHDRKVTMS 3108

Human  1568 VIDGLRVLEESLPPTEATWKIKGPI------YLGGV--APGKAVKNVQINSIYSFSGCLSNLQLN 1624
            |..|     .:...|.|..|:...|      .:||:  :|.|...::.:. :..|.|||..:.:|
  Fly  3109 VEIG-----RTDQKTSAQMKLPKKIGASQLLLVGGLPQSPVKVSSDLYVR-LEPFKGCLRRVSIN 3167

Human  1625 G--ASITSASQTFSVTPCFEGPMETGTYFSTEGGYVVLDESFNIGLKFEIAFEVRPRSSSGTLVH 1687
            .  ..:....:..:|..||. .:|.|:||..: .|.:..::||:|...::..|.|....||.|:.
  Fly  3168 NNTQDLARPGKHSNVGQCFP-TVERGSYFPGD-AYAIYKKNFNVGKYLDLETEFRTSELSGILLS 3230

Human  1688 GHSVNG-EYLNVHMKNGQVIVKVNNG----IRDFSTSVTPKQSLCDGRWHRITVIRDSNVVQLDV 1747
            ....|| ..|::.:.||.:|...:.|    :| ..:|:..|.:|||.:||.|:.:.|...:.|.:
  Fly  3231 VSDPNGFPALSLELHNGNIIFSCDPGNGAPMR-VESSLPTKYALCDNKWHNISALYDGEQIVLRI 3294

Human  1748 DS--EVNHVVGPLNPKPIDHREPVFVGGVPESLLTPRLAPSKPFTGCIRHFVI 1798
            |.  .|..|....|...:..|.|:::||:|||..:..|...:.|.|||||..|
  Fly  3295 DQLPAVISVGNQGNAGKVQTRSPLYIGGLPESAPSGSLISRENFKGCIRHVSI 3347

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LAMA4NP_001098676.2 EGF_Lam 81..130 CDD:238012 20/48 (42%)
EGF_Lam 131..185 CDD:238012 23/54 (43%)
EGF_Lam 187..238 CDD:238012 15/51 (29%)
Laminin_I 296..554 CDD:283627 60/299 (20%)
SPEC 339..531 CDD:295325 43/211 (20%)
COG1340 426..724 CDD:224259 76/333 (23%)
Prefoldin 510..609 CDD:298833 27/112 (24%)
Laminin_II 734..861 CDD:283628 30/143 (21%)
LamG 835..1012 CDD:238058 37/194 (19%)
LamG 1049..1207 CDD:238058 46/196 (23%)
LamG 1237..1376 CDD:238058 46/169 (27%)
LamG 1492..1624 CDD:238058 33/142 (23%)
LamG 1648..1799 CDD:238058 49/158 (31%)
wbNP_723870.1 Laminin_N 164..396 CDD:278484
EGF_Lam 401..450 CDD:238012
TNFRSF <407..507 CDD:304602
EGF_Lam 505..552 CDD:238012
Laminin_EGF 550..597 CDD:278482
Laminin_B 660..798 CDD:278481
EGF_Lam 851..900 CDD:238012
Laminin_EGF <943..971 CDD:278482
VSP 953..1414 CDD:146106
Laminin_EGF 974..1018 CDD:278482
EGF_Lam 1017..1065 CDD:238012
Laminin_EGF 1065..>1105 CDD:278482
EGF_Lam 1150..1197 CDD:238012
Laminin_EGF 1199..1247 CDD:278482
EGF_Lam 1247..1292 CDD:238012
Laminin_EGF 1294..1342 CDD:278482
Laminin_EGF 1340..1392 CDD:278482
Laminin_B 1486..1611 CDD:278481
EGF_Lam 1669..1716 CDD:238012 20/48 (42%)
Laminin_EGF 1718..1767 CDD:278482 22/49 (45%)
EGF_Lam 1772..1819 CDD:238012 15/53 (28%)
CrfC <1933..2267 CDD:223771 85/378 (22%)
Laminin_II 2277..2400 CDD:283628 28/135 (21%)
LamG 2399..>2492 CDD:304605 22/108 (20%)
Laminin_G_2 2616..2755 CDD:280389 38/167 (23%)
Laminin_G_2 2804..2944 CDD:280389 41/144 (28%)
Laminin_G_2 3038..3169 CDD:280389 35/147 (24%)
LamG 3192..3347 CDD:238058 48/156 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100395
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
43.670

Return to query results.
Submit another query.