Protein Alignment LAMA4 and SP2353

DIOPT Version :10

• Sequence 1: NP_001098676.2
• Gene: LAMA4 / 3910
• HGNCID: 6484
• Length: 1823
• Species: Homo sapiens
• Sequence 2: NP_611082.2
• Gene: SP2353 / 36771
• FlyBaseID: FBgn0034070
• Length: 1361
• Species: Drosophila melanogaster
• Alignment Length: 777
• Identity: 163/777 - (20%)
• Similarity: 272/777 - (35%)
• Gaps: 203/777 - (26%)

Human  1201 CMKGFQFQKKDFN--LLEQTETLGVGYGCPEDSLISRRAYFNGQSFIA---------SIQKISFF 1254
            |::|::..|..::  ::..|.....|.|..::.::    |..|.||.|         |:.|.:|.
  Fly    69 CIEGYELNKNGYSCQVINATSNSLDGRGKSDEDVL----YQKGASFSAKLANDDGGKSMAKSTFA 129

Human  1255 ------------------DGFEG-GFNFRTLQPNGLLF------------------------YYA 1276
                              .|.|| .:::..|:.:....                        ||.
  Fly   130 LSAAQSASPAGNENGEDESGSEGDSYDYGELEDSNSETQEQKQKSLNLQQQQQQQQKVNSNDYYI 194

Human  1277 SGSDVFSISLDNGTVIMDVKGIKVQSVDKQYNDGLSHFVISSVSPTRYELIVDKSRVGSKNPTKG 1341
            |...:...|...|....||...|..|.          .:.|||.||........:...:...|..
  Fly   195 SAESINFNSESEGQEQQDVADFKAAST----------MLPSSVPPTPSRSTTRATASTTTTTTTT 249

Human  1342 KIEQTQASEKKFYFGGSPISAQYANFTGCISNAYFTRVDRDV--EVEDFQ---RYTEKVHTSLYE 1401
            :...|:|.:::       :...|....|....:|..:.|..|  :|.:.|   |...|..|  |:
  Fly   250 RRSPTRAPKQR-------VDVDYGEGDGSDDYSYSYKSDMSVYDDVNNNQLNLRRNSKSQT--YQ 305

Human  1402 CPIESSPLFLLHKKGKNLSK-PKASQNK-------KGGKSKDAPSWDPV---ALKLPERNTP--- 1452
            ....::       ..||..| |..:.||       :..:.::..:.:|.   |....:|:||
  Fly   306 QTSNTN-------TAKNRRKYPNVTSNKVQMHITRETNRLENISAAEPAVVGAAMTTDRSTPTCN 363

Human  1453 ----RNSHCHLSNSPRAIEHAYQYGGTANSRQE----------------FEHLKGDFGAKSQFSI 1497
                .:..|.|..:..:......:|.|.|..||                |..|.|.: ...|..|
  Fly   364 LDCGSDGICALEATAASSRCLCPFGKTGNGCQEDIRAHVPRFAKRSWLAFPALHGAY-KHVQLRI 427

Human  1498 RLRTRSSHGMIFYVSDQEE--NDFMTLFLAHGRLVYMFNVGHKKLKIRSQEKYNDGLWHDVIFIR 1560
            ..|..|..|:|....::::  .|||.|.|..|.:.:.|:.|.....:||:|......|:.||..|
  Fly   428 EFRPESFDGIILLSGERDDLTGDFMALLLNKGFVEFWFDCGSGVGSVRSRETILLNEWNSVIIYR 492

Human  1561 ERSSGRLVID-GLRVLEESLPPTEATWKIKGPIYLGGVA--PGKAVKNVQINSIYSFSGCLSNL- 1621
            .|....||:: |.:|...| ....:....:.|::|||:.  .|.| |.:.:..  .|:||:...
  Fly   493 HRWDAWLVLNHGTKVQGRS-NGLFSRITFREPVFLGGIGNITGLA-KRLPLAE--GFAGCIRRFV 553

Human  1622 ---------------QLNGASITSASQTFSVT-PCFEG----PMETGTYFSTEGGYV-------- 1658
                           .:||..|...|....|. ||..|    |.:.|.......|:|
  Fly   554 ANEHDYKFTEHPLGDVINGFDIQDCSTDKCVRYPCQHGGKCLPSDQGAICLCPIGFVGDLCEIRM 618

Human  1659 -VLDESFNIGLKF--------------EIAFEVRPRSSSGTLVH-GHSVNGEYLNVHMKNGQVIV 1707
             :...:|| |..|              |:...::|..:.|.::: |....|:::.:::
  Fly   619 DLQVPAFN-GSSFLRYAPLGDSALIWLELKVTLKPEQADGLILYSGPEHRGDFIALYL------- 675

Human  1708 KVNNGIRDFS-------TSVTPKQSLCDGRWHRITVIRDSNVVQLDVDSEVNHVVGPLNPKPIDH 1765
              |:|..:|:       ..|..:.||..|:||.|.:.|.:.:..|.||.  :..|..::.....|
  Fly   676 --NDGFVEFAFDLGSGPALVRSEHSLSLGQWHTIKISRTARLAVLKVDK--HQEVLTISSNGFWH 736

Human  1766 ---REPVFVGGVPESLLTPRLAPSKP-FTGCIRHFVIDGHPVSFSKAALVSGAVSINSCPAA 1823
               .:.:|||||......|.....|| |.|||:...|:||.:.....||  |..:|.:||.|
  Fly   737 LSLDQNLFVGGVNHVDRLPLDLKYKPFFVGCIQRIDINGHSLGIVAEAL--GGSNIGNCPHA 796

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LAMA4	NP_001098676.2	EGF_Lam	81..130	CDD:238012
		EGF_Lam	131..185	CDD:238012
		EGF_Lam	187..238	CDD:238012
		Laminin_I	298..554	CDD:310534
		CwlO1	529..>757	CDD:443091
		Laminin_II	734..861	CDD:368703
		LamG	835..1012	CDD:238058
		LamG	1049..1207	CDD:238058	2/5 (40%)
		LamG	1237..1376	CDD:238058	31/190 (16%)
		LamG	1492..1624	CDD:238058	37/152 (24%)
		LamG	1648..1799	CDD:238058	40/185 (22%)
SP2353	NP_611082.2	FXa_inhibition	53..82	CDD:464251	3/12 (25%)
		LamG	404..555	CDD:238058	40/155 (26%)
		EGF	583..612	CDD:394967	8/28 (29%)
		LamG	625..774	CDD:238058	37/160 (23%)
		LamG	1205..1340	CDD:214598