DRSC/TRiP Functional Genomics Resources

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Protein Alignment LAMA4 and LanB1

DIOPT Version :10

Sequence 1:NP_001098676.2 Gene:LAMA4 / 3910 HGNCID:6484 Length:1823 Species:Homo sapiens
Sequence 2:NP_476618.1 Gene:LanB1 / 34068 FlyBaseID:FBgn0261800 Length:1788 Species:Drosophila melanogaster


Alignment Length:1064 Identity:243/1064 - (22%)
Similarity:392/1064 - (36%) Gaps:273/1064 - (25%)


- Green bases have known domain annotations that are detailed below.


Human    21 CSRAASGDDNAFPFDIEGSSA-----VGRQDP------------PETSEPRVALGRLPPAAEKCN 68
            |.:.|.|   .:.|..||..|     :|.:|.            |.|      .||   ...:|.
  Fly   819 CDQCAPG---TYGFGPEGCKACDCNSIGSKDKYCDLITGQCQCVPNT------YGR---ECNQCQ 871

Human    69 AGFFHTLSGECVPCDCNGNSNECLDGSGYCVHCQRNTTGEHCEKCLDGYIGDSIRGAPQFCQPCP 133
            .|:::  ..||..|.|||::..|....|.|:.||.:|||..|:.|||||.|:.:.|:...|:||.
  Fly   872 PGYWN--FPECRVCQCNGHAATCDPIQGTCIDCQDSTTGYSCDSCLDGYYGNPLFGSEIGCRPCR 934

Human   134 CP------LPHLANFAESCY--RKNGAVRCICNENYAGPNCERCAPGYYGNPLLIGSTCKKCDCS 190
            ||      |.|    |:.|.  .:|..:.|.|.|.|:|..||.||..::||| ..|.||.||:||
  Fly   935 CPETVASGLAH----ADGCSLDTRNNNMLCHCQEGYSGSRCEICADNFFGNP-DNGGTCSKCECS 994

Human   191 GNSDPNLIFE--DCDEVTGQCRNCLRNTTGFKCERCAPGYYGDARIAKNCAVCNCGG-------G 246
            .|.|   :::  :||..||.|..||..|||..||.|..|::||| :.:||..|.|..       .
  Fly   995 NNVD---LYDTGNCDRQTGACLKCLYQTTGDHCELCKDGFFGDA-LQQNCQQCECDFLGTNNTIA 1055

Human   247 PCDSVTGECLEEGFEPPTGMDCPTISCDKCV---WDLTDDLRLAALSIEEGKSGVLSVSSGAAAH 308
            .||..||:|       |...:...:.||:|.   |                     .::||....
  Fly  1056 HCDRFTGQC-------PCLPNVQGVRCDQCAENHW---------------------KIASGEGCE 1092

Human   309 R-HVNEINATIYLLKTKLSERENQY-------------ALRKIQINNAEN-TMKSLLSDVEELVE 358
            . :.:.|.|        |.|:.|.|             |..:.|.:...| ..|....:.::...
  Fly  1093 SCNCDPIGA--------LHEQCNSYTGQCQCKPGFGGRACNQCQAHYWGNPNEKCQPCECDQFGA 1149

Human   359 KENQASRK-GQLVQKESM-----------------------------DTINHASQLVEQAHDMRD 393
            .:.|..|: |..|..|.:                             |.|..|.:....|..:|.
  Fly  1150 ADFQCDRETGNCVCHEGIGGYKCNECARGYIGQFPHCSPCGECFNNWDLILSALEDATTATILRA 1214

Human   394 K-IQEINNKMLYYGEEHELSPKEISEKLVLAQKMLEEIRSRQPFFTQRELVD-EEADEAYELLSQ 456
            | |:::.....|..|..||     .:||...:.:|:.        |...||| |:.|  ||..|.
  Fly  1215 KEIKQVGATGAYTSEFSEL-----DKKLQHIRNLLQN--------TSVSLVDIEKLD--YETQSL 1264

Human   457 AESWQRLH---NETR----------TLFPVVLEQLDDYNAKLSDLQEALDQ------------AL 496
            .:..|..|   :||.          :|..|.||.|.:::..:..|.:.|.:            ||
  Fly  1265 RDQLQASHGRLSETEQNLDDIYNSLSLSGVELESLQNHSRLVQQLSKELKENGIQLQESNIEGAL 1329

Human   497 NYVRDA-EDMNRATAARQRDHEKQQERVREQMEVVNMSLSTSADSLTTPRLTLSELDDIIKNASG 560
            |..|.| |.::..:..:...:|......|....|.|:|....|           |.||:..|.. 
  Fly  1330 NLTRHAYERVSNLSTLKDEANELASNTDRNCKRVENLSNKIQA-----------EADDLANNNK- 1382

Human   561 IYAEIDGAKSELQVKLSNLSNLSHDLV---------------------------------QEAID 592
               .|:..::||....|.:..|::.:.                                 :||:.
  Fly  1383 ---LIEDYRAELTSLTSQIPELNNQVCGKPGDPCDSLCGGAGCGHCGGFLSCEHGAKTHSEEALK 1444

Human   593 HAQDLQQEANELSRKLHSSD--MNGLVQKALDASNVYENI-------VNYVSEANETAEFALNTT 648
            .|:|.:   ..::.|...:|  :..|.|..|:||..||..       ..|:::.|...:.|.|  
  Fly  1445 VAKDAE---TAITSKKDQADQTIRALTQAKLNASEAYEKAKRGFEQSERYLNQTNANIKLAEN-- 1504

Human   649 DRIYDAVSGIDTQIIYHKDESENLLNQARELQAKAESSSDEAVADTSRRVGGALARKSALKTRLS 713
              ::.|::...........||:.|..:..:|..|.|....|.:.|...|...:|....|:..|..
  Fly  1505 --LFIALNNFQENKTASPSESKELAQKTLDLDLKLEPEEIETLGDQINRAVSSLKNVEAIIYRTK 1567

Human   714 ---DAVKQLQA---AERGDAQQRLGQSRLITEE---ANRTTMEVQQATAPMANNLTNWSQNLQHF 769
               |.|..||:   |.:..|.:.|..:..:.|.   |:.:..:.:.|.....:|:....|:|:..
  Fly  1568 PDLDRVNNLQSIANATKEKADKILDSANSVVESLAAADESQGKAKDAIQQANSNIELAGQDLEKI 1632

Human   770 DSSAYN--TAVNSARDAVRNLTEVVPQLLDQLRTVEQKRPASNVSASIQRIRELIAQTRSVASKI 832
            |...|:  ...|:....|..|.:.|.:|  |...::..|.|..::.....::....:.|..|:.:
  Fly  1633 DEETYSAEAPANNTAQQVEKLAKKVQKL--QNNIMKNDRDAKEITKEAGSVKLEAMRARGEANNL 1695

Human   833 QVSMMFDGQSAVEVHSRTSMDDLKAFTSLSLYMKPPV-KRPELTETADQFILYLGSKNAKKEYMG 896
            |.:.....|:..:..||:.....:|...|....|..| ...:|.:..|...:||   |..::.:.
  Fly  1696 QSATSATNQTLTDRASRSENARERAKQLLQRASKLTVDTNAKLKDLNDLQTVYL---NKNQQLLR 1757

Human   897 LAIK--------NDNLVYVYNLGT 912
            |..:        |::|:::...|:
  Fly  1758 LQAEIGPLNKELNEHLIHIKERGS 1781

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LAMA4NP_001098676.2 EGF_Lam 81..130 CDD:238012 20/48 (42%)
EGF_Lam 131..185 CDD:238012 23/61 (38%)
EGF_Lam 187..238 CDD:238012 22/52 (42%)
Laminin_I 298..554 CDD:310534 65/328 (20%)
CwlO1 529..>757 CDD:443091 53/278 (19%)
Laminin_II 734..861 CDD:368703 23/131 (18%)
LamG 835..1012 CDD:238058 16/87 (18%)
LamG 1049..1207 CDD:238058
LamG 1237..1376 CDD:238058
LamG 1492..1624 CDD:238058
LamG 1648..1799 CDD:238058
LanB1NP_476618.1 Laminin_N 54..286 CDD:459653
EGF_Lam 287..343 CDD:238012
Laminin_EGF 355..415 CDD:395007
Laminin_EGF 418..475 CDD:395007
EGF_Lam 477..526 CDD:238012
EGF_Lam 529..567 CDD:214543
EGF_Lam 789..834 CDD:214543 5/17 (29%)
Laminin_EGF 837..885 CDD:395007 11/58 (19%)
Laminin_EGF 883..930 CDD:395007 20/46 (43%)
Laminin_EGF 933..988 CDD:395007 21/59 (36%)
Laminin_EGF 991..1035 CDD:395007 20/46 (43%)
Laminin_EGF 1043..1091 CDD:395007 14/75 (19%)
Laminin_EGF 1094..1142 CDD:395007 10/55 (18%)
Laminin_EGF 1142..1190 CDD:395007 5/47 (11%)
Mplasa_alph_rch 1228..>1771 CDD:275316 116/584 (20%)
cc_DmLAMB1-like_C 1717..1786 CDD:411973 13/68 (19%)
Blue background indicates that the domain is not in the aligned region.

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