DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3437 and MCM3AP

DIOPT Version :9

Sequence 1:	NP_648318.2	Gene:	CG3437 / 39096	FlyBaseID:	FBgn0035998	Length:	349	Species:	Drosophila melanogaster
Sequence 2:	NP_003897.2	Gene:	MCM3AP / 8888	HGNCID:	6946	Length:	1980	Species:	Homo sapiens

Alignment Length:	339	Identity:	85/339 - (25%)
Similarity:	144/339 - (42%)	Gaps:	25/339 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GSCESFCPDGEAKMRIREKLLHYFELKNG-QKNKPGVLVKEFTRSAADVKMPMPKEMRTEAALTK 69
            |:|...||:.|..||.....|..||:..| .:......|||::||:||.:.|:|.|:|....|::
Human   635 GTCLDMCPEKERYMRETRSQLSVFEVVPGTDQVDHAAAVKEYSRSSADQEEPLPHELRPLPVLSR 699

  Fly    70 TVEYLLKDIILDTRKPYNVAYDFIFDRLRAVRREIVIQMYDASQKICLLEPIVMFLAYSRYRLCE 134
            |::||:..|:..........|||:::|.|.:|::|..|.......:.|:|....|..:..:.:||
Human   700 TMDYLVTQIMDQKEGSLRDWYDFVWNRTRGIRKDITQQHLCDPLTVSLIEKCTRFHIHCAHFMCE 764

  Fly   135 EPIEKFDLKICNQHLQECLTGVLCCYEELEDLESSREPTVRELERRCFIESLYQ----LFNLGSP 195
            ||:..||.||.|:::.:||..:...|::|           |.....|..|:.:|    |.:|...
Human   765 EPMSSFDAKINNENMTKCLQSLKEMYQDL-----------RNKGVFCASEAEFQGYNVLLSLNKG 818

  Fly   196 ESFTRALTLPDYVRRDATFKLCFGICLAFQQGNLYRVLMGVPQLPHILCAVAAAKLQVIRRSLLQ 260
            :...........||..:..|.......|....|..|....|....::...:.......||:..|:
Human   819 DILREVQQFHPAVRNSSEVKFAVQAFAALNSNNFVRFFKLVQSASYLNACLLHCYFSQIRKDALR 883

  Fly   261 IFTHAY--NNKQLTV-PVPYLLRLLLFDGPTGLQD--QCRHYNISLTADRKAVQFNKTDFNHNAE 320
            ....||  :.::.|: |:..::|:|||.......|  .|.    .||.....|:.|::.|.....
Human   884 ALNFAYTVSTQRSTIFPLDGVVRMLLFRDCEEATDFLTCH----GLTVSDGCVELNRSAFLEPEG 944

  Fly   321 VFTPQHERFVESKL 334
            :...:...|:..||
Human   945 LSKTRKSVFITRKL 958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3437	NP_648318.2	SAC3_GANP	56..284	CDD:281402	55/234 (24%)
MCM3AP	NP_003897.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..67
		NupH_GANP	2..291	CDD:293373
		FG-repeats	33..340
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..247
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	266..432
		RRM_MCM3A_like	435..506	CDD:240889
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	511..557
		Interaction with PCID2 and SEM1. /evidence=ECO:0000269\|PubMed:22307388	686..1003		67/288 (23%)
		SAC3_GANP	686..910	CDD:281402	55/234 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	998..1038
		CID	1162..1256
		Interaction with ENY2. /evidence=ECO:0000269\|PubMed:22307388	1162..1200
		CID_GANP	1164..1234	CDD:293371
		Interaction with ENY2. /evidence=ECO:0000269\|PubMed:22307388	1207..1235
		Interaction with Centrin. /evidence=ECO:0000269\|PubMed:22307388	1236..1256
		MCM3AP_GANP	1262..1976	CDD:293374
		Acetyltransferase	1658..1790
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5079
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1280
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840