DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3437 and mcm3ap

DIOPT Version :9

Sequence 1:	NP_648318.2	Gene:	CG3437 / 39096	FlyBaseID:	FBgn0035998	Length:	349	Species:	Drosophila melanogaster
Sequence 2:	XP_005167925.1	Gene:	mcm3ap / 436589	ZFINID:	ZDB-GENE-040715-1	Length:	2118	Species:	Danio rerio

Alignment Length:	344	Identity:	81/344 - (23%)
Similarity:	148/344 - (43%)	Gaps:	18/344 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GSCESFCPDGEAKMRIREKLLHYFE-LKNGQKNKPGVLVKEFTRSAADVKMPMPKEMRTEAALTK 69
            |:|...||:.|..||.....|..|| :.:.:|......:||::||:||.:.|:|.|:|....|:.
Zfish   687 GTCPDMCPEKERYMRETRNQLSVFEVVPDTEKVDHYAAIKEYSRSSADQEEPLPHELRPLPVLSM 751

  Fly    70 TVEYLLKDIILDTRKPYNVAYDFIFDRLRAVRREIVIQMYDASQKICLLEPIVMFLAYSRYRLCE 134
            |::||:..|:..........|||:::|.|.:|::|..|.....:.:.|:|....|..:..:.||:
Zfish   752 TMDYLVTQIMDQGEGNCRDWYDFVWNRTRGIRKDITQQHLCDPETVSLIEKCTRFHIHCAHHLCQ 816

  Fly   135 EPIEKFDLKICNQHLQECLTGVLCCYEEL--EDLESSREPTVRELERRCFIESLYQLFNLGSPES 197
            ||:..||.||.|:::.:||..:...|::|  :::...:|...|:..         .|..|...:.
Zfish   817 EPMMSFDAKINNENMTKCLQSLKEMYQDLATKEVYCPKEAEFRQYN---------VLVKLNDGDI 872

  Fly   198 FTRALTLPDYVRRDATFKLCFGICLAFQQGNLYRVLMGVPQLPHILCAVAAAKLQVIRRSLLQIF 262
            ..........:|..........:..|....|..|....|....::...:.......:||..|:|.
Zfish   873 LREVQQFRKEIRESPEVTFAVQVFAALNSNNFVRFFKLVSAASYLSSCILHRYFNQVRRQALKIL 937

  Fly   263 THAY---NNKQLTVPVPYLLRLLLFDGPTGLQDQCRHYNISLTADRKAVQFNKTDFNHNAEVFTP 324
            ..|:   :.:....||...:|:|:|...|...:..:.|  .||.....|:.::|.: ...:...|
Zfish   938 NVAFTVGSQRSTIFPVEDFVRMLMFRNATEATEFIQQY--GLTVSDGMVELSRTAY-QEPDYSLP 999

  Fly   325 QHERFVESKLKRIYIPEVL 343
            |.:.....|.:.:.|.||:
Zfish  1000 QKKSVAIEKKRTVLIGEVV 1018

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3437	NP_648318.2	SAC3_GANP	56..284	CDD:281402	51/232 (22%)
mcm3ap	XP_005167925.1	NupH_GANP	2..310	CDD:293373
		Nucleoporin_FG	3..81	CDD:290362
		RRM_MCM3A_like	481..553	CDD:240889
		SAC3_GANP	738..962	CDD:281402	51/232 (22%)
		CID_GANP	1226..1294	CDD:293371
		MCM3AP_GANP	1324..2114	CDD:293374
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5079
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1280
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840