DRSC/TRiP Functional Genomics Resources

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Protein Alignment phol and GLIS2

DIOPT Version :10

Sequence 1:NP_648317.1 Gene:phol / 39095 FlyBaseID:FBgn0035997 Length:669 Species:Drosophila melanogaster
Sequence 2:NP_115964.2 Gene:GLIS2 / 84662 HGNCID:29450 Length:524 Species:Homo sapiens


Alignment Length:273 Identity:51/273 - (18%)
Similarity:89/273 - (32%) Gaps:92/273 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   174 SVMFCTVLNYICL-RMLGENPEQDACKRARQWILDRGGVIFIPSWGKFWLSILGVYDWSGTNPTP 237
            ||..|.|.:.:.: .:|..|.|:.:..|..|         ..|.|..|:                
Human    23 SVEICNVCSCVSVENVLYVNCEKVSVYRPNQ---------LKPPWSNFY---------------- 62

  Fly   238 PELLMLPSFLPI-HPGKILCYSRMVSI-----PMSYLYGKRFVGPITPLILLLREELYLEPYEEI 296
             .|....:||.| :|...:.:|..||:     .:..:.|..|:|              |...:::
Human    63 -HLNFQNNFLNILYPNTFVNFSHAVSLHLGNNKLQNIEGGAFLG--------------LSALKQL 112

  Fly   297 NWKKSRRLYAKEDMYYAHPLVQDLLSD-TLQNFVEPLLTRWPLNKLVREKALQLTMKHIHYEDEN 360
            :...:.....:.|.:.....::.|.:| .|..::|    |...|||.:.|.|.|....|.:..:|
Human   113 HLNNNELKILRADTFLGIENLEYLQADYNLIKYIE----RGAFNKLHKLKVLILNDNLISFLPDN 173

  Fly   361 -------SH------------YITIGCVEKV------------------LCMLACWVEN-PNGDY 387
                   :|            |  ||.:|.:                  |..|..|:|| |...|
Human   174 IFRFASLTHLDIRGNRIQKLPY--IGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIY 236

  Fly   388 FKKHLARIPDYMW 400
            ..:.:...|..::
Human   237 IGEAICETPSDLY 249

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pholNP_648317.1 COG5048 <504..614 CDD:227381
C2H2 Zn finger 504..526 CDD:275368
C2H2 Zn finger 533..553 CDD:275368
C2H2 Zn finger 561..583 CDD:275368
C2H2 Zn finger 591..613 CDD:275368
GLIS2NP_115964.2 Interaction with CTNND1. /evidence=ECO:0000250 35..174 33/182 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 39..62 7/31 (23%)
Transcription activation. /evidence=ECO:0000250 71..137 11/79 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 84..114 6/43 (14%)
Transcription repression. /evidence=ECO:0000250 148..171 8/22 (36%)
C2H2 Zn finger 213..229 CDD:275368 3/15 (20%)
COG5048 233..>327 CDD:227381 2/17 (12%)
C2H2 Zn finger 237..257 CDD:275368 1/13 (8%)
C2H2 Zn finger 265..287 CDD:275368
C2H2 Zn finger 295..317 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 439..480
Blue background indicates that the domain is not in the aligned region.

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