Protein Alignment phol and ZIC3

DIOPT Version :10

• Sequence 1: NP_648317.1
• Gene: phol / 39095
• FlyBaseID: FBgn0035997
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_003404.1
• Gene: ZIC3 / 7547
• HGNCID: 12874
• Length: 467
• Species: Homo sapiens
• Alignment Length: 130
• Identity: 53/130 - (40%)
• Similarity: 69/130 - (53%)
• Gaps: 10/130 - (7%)

  Fly   498 EEPKFRCTHRGCNKEFRNHSAMRKHM---HTHGP--RGHVC--NVC---GKSFVESSKLKRHQLV 552
            :|.:.....:.|::.|.....:..|:   |..||  ..|||  ..|   ||||....||..|..|
Human   257 DEAQLSRPKKSCDRTFSTMHELVTHVTMEHVGGPEQNNHVCYWEECPREGKSFKAKYKLVNHIRV 321

  Fly   553 HTGEKPFECTFEGCGKRFSLDFNLRTHVRIHTGDRPYHCPIDGCSKCFAQSTNLKSHMLTHTKPK 617
            |||||||.|.|.||||.|:...||:.|.|.|||::|:.|..:||.:.||.|::.|.||..||..|
Human   322 HTGEKPFPCPFPGCGKIFARSENLKIHKRTHTGEKPFKCEFEGCDRRFANSSDRKKHMHVHTSDK 386

  Fly   618  617
            Human   387  386

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phol	NP_648317.1	COG5048	<504..614	CDD:227381	49/119 (41%)
		C2H2 Zn finger	504..526	CDD:275368	4/24 (17%)
		C2H2 Zn finger	533..553	CDD:275368	9/24 (38%)
		C2H2 Zn finger	561..583	CDD:275368	11/21 (52%)
		C2H2 Zn finger	591..613	CDD:275368	9/21 (43%)
ZIC3	NP_003404.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	66..107
		zf_ZIC	245..290	CDD:436441	5/32 (16%)
		Nuclear localization signal	297..322		9/24 (38%)
		C2H2 Zn finger	302..322	CDD:275368	8/19 (42%)
		SFP1	<324..408	CDD:227516	32/63 (51%)
		C2H2 Zn finger	330..352	CDD:275368	11/21 (52%)
		Nuclear localization signal	330..352		11/21 (52%)
		C2H2 Zn finger	360..382	CDD:275368	9/21 (43%)
		C2H2 Zn finger	390..410	CDD:275368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	404..467