DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment phol and YY1

DIOPT Version :9

Sequence 1:	NP_001287005.1	Gene:	phol / 39095	FlyBaseID:	FBgn0035997	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_003394.1	Gene:	YY1 / 7528	HGNCID:	12856	Length:	414	Species:	Homo sapiens

Alignment Length:	610	Identity:	170/610 - (27%)
Similarity:	223/610 - (36%)	Gaps:	279/610 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 VEQDPYTVLAGDPMGEESESFLIEEIIDDYDDEANIVVDSG-----------EFFEHYEYYPVDR 114
            ||..|...:....:|||.|        :|.|||.....|.|           ....|:.::
Human    28 VETIPVETIETTVVGEEEE--------EDDDDEDGGGGDHGGGGGHGHAGHHHHHHHHHHH---- 80

  Fly   115 LDRLTSVTVATADALPPPIIMQQ-TSDD--------EEFIEEDGQQMTSSCDGDG--DED---DE 165
                           ||.|.:|. .:||        |..:.:..:::....|.||  .||   |:
Human    81 ---------------PPMIALQPLVTDDPTQVHHHQEVILVQTREEVVGGDDSDGLRAEDGFEDQ 130

  Fly   166 ATAPATTNA---FEIASEMLTTIEATNIKEEQLESDFYMKATEDSNSSNGQLQDFKLFGSSRVER 227
            ...|....|   .:...:.|.|:.|..            |:....:||:         |..||::
Human   131 ILIPVPAPAGGDDDYIEQTLVTVAAAG------------KSGGGGSSSS---------GGGRVKK 174

  Fly   228 PMGNSAA---------------------KRWKQTKVPIRITQDEFNVTLWSSLNSEDEDEEEELE 271
            ..|..:.                     |:|:|.:|.|:..:.||:||:|||...:|.|.|..:|
Human   175 GGGKKSGKKSYLSGGAGAAGGGGADPGNKKWEQKQVQIKTLEGEFSVTMWSSDEKKDIDHETVVE 239

  Fly   272 EPPGCAGTTSVTSSSAAQNEGSPSMPKLIIDEHMINHDVLSDGIGNEYVI---LPDPFSASAVTD 333
            |                |..|..|.|..                 :||:.   ||.
Human   240 E----------------QIIGENSPPDY-----------------SEYMTGKKLPP--------- 262

  Fly   334 VEEVVNAFMGDVKGEEDSQPLSEQLIYAENQLEEAYGNIELIENMPNNVELIQTPGPGPATVSVA 398
                     |.:.|.:.|.|
Human   263 ---------GGIPGIDLSDP--------------------------------------------- 273

  Fly   399 LSKVNGCVPNPQPALPKLVLQNSSTNVRLKSAGNQSKVTKRQLTAAAQVATPNPPPPLVASSNPA 463
                                                    :||...|::
Human   274 ----------------------------------------KQLAEFARM---------------- 282

  Fly   464 RPQRPTIVTKLPTAVANQTAGNAMGAAGAAGEEDEEPK-FRCTHRGCNKEFRNHSAMRKHMHTHG 527
            :|::.                          :||:.|: ..|.|:||.|.||::||||||:||||
Human   283 KPRKI--------------------------KEDDAPRTIACPHKGCTKMFRDNSAMRKHLHTHG 321

  Fly   528 PRGHVCNVCGKSFVESSKLKRHQLVHTGEKPFECTFEGCGKRFSLDFNLRTHVRIHTGDRPYHCP 592
            ||.|||..|||:||||||||||||||||||||:|||||||||||||||||||||||||||||.||
Human   322 PRVHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPYVCP 386

  Fly   593 IDGCSKCFAQSTNLKSHMLTHTKPK 617
            .|||:|.||||||||||:|||.|.|
Human   387 FDGCNKKFAQSTNLKSHILTHAKAK 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phol	NP_001287005.1	zf-C2H2	502..526	CDD:278523	14/23 (61%)
		COG5048	<504..614	CDD:227381	92/109 (84%)
		C2H2 Zn finger	504..526	CDD:275368	14/21 (67%)
		zf-C2H2	531..553	CDD:278523	18/21 (86%)
		C2H2 Zn finger	533..553	CDD:275368	16/19 (84%)
		zf-H2C2_2	546..571	CDD:290200	23/24 (96%)
		C2H2 Zn finger	561..583	CDD:275368	21/21 (100%)
		zf-H2C2_2	575..602	CDD:290200	22/26 (85%)
		C2H2 Zn finger	591..613	CDD:275368	17/21 (81%)
YY1	NP_003394.1	Interaction with the SMAD1/SMAD4 complex	1..170		36/189 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..81		11/74 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..203		7/66 (11%)
		Involved in nuclear matrix association	257..341		44/228 (19%)
		COG5048	<268..407	CDD:227381	100/265 (38%)
		Binding to DNA	295..414		95/117 (81%)
		C2H2 Zn finger	298..320	CDD:275368	14/21 (67%)
		C2H2 Zn finger	327..347	CDD:275368	16/19 (84%)
		Involved in repression of activated transcription	333..371		35/37 (95%)
		C2H2 Zn finger	355..377	CDD:275368	21/21 (100%)
		Involved in masking transactivation domain	371..397		21/25 (84%)
		C2H2 Zn finger	385..407	CDD:275368	17/21 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	84	1.000	Domainoid score	I8245
eggNOG	1	0.900	-	-		E33208_3BEPX
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2955
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D362296at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.830