DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment phol and Yy1

DIOPT Version :9

Sequence 1:	NP_001287005.1	Gene:	phol / 39095	FlyBaseID:	FBgn0035997	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_033563.2	Gene:	Yy1 / 22632	MGIID:	99150	Length:	414	Species:	Mus musculus

Alignment Length:	604	Identity:	170/604 - (28%)
Similarity:	225/604 - (37%)	Gaps:	267/604 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 VEQDPYTVLAGDPMGEESESFLIEEIIDDYDDEANIVVDSG-------------EFFEHYEYYPV 112
            ||..|...:....:|||.|        :|.|||.....|.|             ....|:.::
Mouse    28 VETIPVETIETTVVGEEEE--------EDDDDEDGGGGDHGGGGGGHGHAGHHHHHHHHHHHH-- 82

  Fly   113 DRLDRLTSVTVATADALPPPIIMQQ-TSDD--------EEFIEEDGQQMTSSCDGDG--DED--- 163
                             ||.|.:|. .:||        |..:.:..:::....|.||  .||
Mouse    83 -----------------PPMIALQPLVTDDPTQVHHHQEVILVQTREEVVGGDDSDGLRAEDGFE 130

  Fly   164 DEATAPATTNA---FEIASEMLTTIEATNIKEEQLESDFYMKATEDSNSSNGQLQDFKLFGSSRV 225
            |:...|....|   .:...:.|.|:.|..            |:...::|..|::   |..|..:.
Mouse   131 DQILIPVPAPAGGDDDYIEQTLVTVAAAG------------KSGGGASSGGGRV---KKGGGKKS 180

  Fly   226 ERP--MGNSAA-----------KRWKQTKVPIRITQDEFNVTLWSSLNSEDEDEEEELEEPPGCA 277
            .:.  :|..|.           |:|:|.:|.|:..:.||:||:|||...:|.|.|..:||
Mouse   181 GKKSYLGGGAGAAGGGGADPGNKKWEQKQVQIKTLEGEFSVTMWSSDEKKDIDHETVVEE----- 240

  Fly   278 GTTSVTSSSAAQNEGSPSMPKLIIDEHMINHDVLSDGIGNEYVI---LPDPFSASAVTDVEEVVN 339
                       |..|..|.|..                 :||:.   ||.
Mouse   241 -----------QIIGENSPPDY-----------------SEYMTGKKLPP--------------- 262

  Fly   340 AFMGDVKGEEDSQPLSEQLIYAENQLEEAYGNIELIENMPNNVELIQTPGPGPATVSVALSKVNG 404
               |.:.|.:.|.|
Mouse   263 ---GGIPGIDLSDP--------------------------------------------------- 273

  Fly   405 CVPNPQPALPKLVLQNSSTNVRLKSAGNQSKVTKRQLTAAAQVATPNPPPPLVASSNPARPQRPT 469
                                              :||...|::                :|::.
Mouse   274 ----------------------------------KQLAEFARM----------------KPRKI- 287

  Fly   470 IVTKLPTAVANQTAGNAMGAAGAAGEEDEEPK-FRCTHRGCNKEFRNHSAMRKHMHTHGPRGHVC 533
                                     :||:.|: ..|.|:||.|.||::||||||:||||||.|||
Mouse   288 -------------------------KEDDAPRTIACPHKGCTKMFRDNSAMRKHLHTHGPRVHVC 327

  Fly   534 NVCGKSFVESSKLKRHQLVHTGEKPFECTFEGCGKRFSLDFNLRTHVRIHTGDRPYHCPIDGCSK 598
            ..|||:||||||||||||||||||||:|||||||||||||||||||||||||||||.||.|||:|
Mouse   328 AECGKAFVESSKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPYVCPFDGCNK 392

  Fly   599 CFAQSTNLKSHMLTHTKPK 617
            .||||||||||:|||.|.|
Mouse   393 KFAQSTNLKSHILTHAKAK 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phol	NP_001287005.1	zf-C2H2	502..526	CDD:278523	14/23 (61%)
		COG5048	<504..614	CDD:227381	92/109 (84%)
		C2H2 Zn finger	504..526	CDD:275368	14/21 (67%)
		zf-C2H2	531..553	CDD:278523	18/21 (86%)
		C2H2 Zn finger	533..553	CDD:275368	16/19 (84%)
		zf-H2C2_2	546..571	CDD:290200	23/24 (96%)
		C2H2 Zn finger	561..583	CDD:275368	21/21 (100%)
		zf-H2C2_2	575..602	CDD:290200	22/26 (85%)
		C2H2 Zn finger	591..613	CDD:275368	17/21 (81%)
Yy1	NP_033563.2	Interaction with the SMAD1/SMAD4 complex. /evidence=ECO:0000250	1..170		34/180 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	32..83		12/77 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..203		7/58 (12%)
		Involved in nuclear matrix association. /evidence=ECO:0000250	257..341		44/228 (19%)
		COG5048	<268..407	CDD:227381	100/265 (38%)
		Binding to DNA. /evidence=ECO:0000250	295..414		95/117 (81%)
		C2H2 Zn finger	298..320	CDD:275368	14/21 (67%)
		zf-C2H2	325..347	CDD:278523	18/21 (86%)
		C2H2 Zn finger	327..347	CDD:275368	16/19 (84%)
		Involved in repression of activated transcription. /evidence=ECO:0000250	333..371		35/37 (95%)
		zf-H2C2_2	340..365	CDD:290200	23/24 (96%)
		C2H2 Zn finger	355..377	CDD:275368	21/21 (100%)
		zf-H2C2_2	369..396	CDD:290200	22/26 (85%)
		Involved in masking transactivation domain. /evidence=ECO:0000250	371..397		21/25 (84%)
		C2H2 Zn finger	385..407	CDD:275368	17/21 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10637
eggNOG	1	0.900	-	-		E33208_3BEPX
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2955
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D362296at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.830