DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment phol and Yy2

DIOPT Version :9

Sequence 1:NP_001287005.1 Gene:phol / 39095 FlyBaseID:FBgn0035997 Length:669 Species:Drosophila melanogaster
Sequence 2:NP_001364162.1 Gene:Yy2 / 103690827 RGDID:2324567 Length:376 Species:Rattus norvegicus


Alignment Length:577 Identity:156/577 - (27%)
Similarity:201/577 - (34%) Gaps:264/577 - (45%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 AYFTHAHQPTAATIVEQDPYTVLAGDPM--GEESESFLI----EEIIDDYDDEANIVVDSGEFFE 105
            |:..|.|.|    ::...|   |||..:  |:..:..:|    ||:: ||.|..|:::  |..||
  Rat    55 AHGGHYHSP----LIALQP---LAGSNLSNGDHDQEMIIVQTREEVV-DYQDSDNLLL--GTEFE 109

  Fly   106 HYEYYPVDRLDRLTSVTVATADALPPPIIMQQTSDDEEFIEEDGQQMTSSCDGDGDEDDEATAPA 170
            .....||:..|.|...|...:..:               ..|:||...|...|:           
  Rat   110 SQMVLPVNEDDYLQPTTATFSGFM---------------AAENGQDELSPYGGN----------- 148

  Fly   171 TTNAFEIASEMLTTIEATNIKEEQLESDFYMKATEDSNSSNGQLQDFKLFGSSRVERPMGNSAAK 235
                   ...:.|.|||              .|.|..|...|.                     |
  Rat   149 -------LCGLTTIIEA--------------GAEEGVNPDLGD---------------------K 171

  Fly   236 RWKQTKVPIRITQDEFNVTLWSSLNSEDEDEEEELEEPPGCAGTTSVTSSSAAQNEGSPSMPKLI 300
            :|:|.::.|.....||...:|         |:..|:|.|            .|:.|...|.|.  
  Rat   172 QWEQKQIQIDGLDGEFPFAMW---------EDNNLKEDP------------VAEEEAGESTPD-- 213

  Fly   301 IDEHMINHDVLSDGIGNEYVILPDPFSASAVTDVEEVVNAFMGDVKGEEDSQPLSEQLIYAENQL 365
            ..|:|.......:||..  :.|.||                                     .||
  Rat   214 YSEYMTGKKFPPEGIPG--IDLSDP-------------------------------------KQL 239

  Fly   366 EEAYGNIELIENMPNNVELIQTPGPGPATVSVALSKVNGCVPNPQPALPKLVLQNSSTNVRLKSA 430
            .|                                                               
  Rat   240 AE--------------------------------------------------------------- 241

  Fly   431 GNQSKVTKRQLTAAAQVATPNPPPPLVASSNPARPQRPTIVTKLPTAVANQTAGNAMGAAGAAGE 495
                                      ..|..|.:|:     ...|..||                
  Rat   242 --------------------------FTSMKPKKPK-----GDFPRPVA---------------- 259

  Fly   496 EDEEPKFRCTHRGCNKEFRNHSAMRKHMHTHGPRGHVCNVCGKSFVESSKLKRHQLVHTGEKPFE 560
                    |:|:||.|.|:::||||||:|.||||.|||..|||:|||||||||||||||||||::
  Rat   260 --------CSHKGCGKMFKDNSAMRKHLHIHGPRVHVCAECGKAFVESSKLKRHQLVHTGEKPYQ 316

  Fly   561 CTFEGCGKRFSLDFNLRTHVRIHTGDRPYHCPIDGCSKCFAQSTNLKSHMLTHTKPK 617
            |||||||:||||||||||||||||||:|:.||.|.|:|.||||||||||:|||.|.|
  Rat   317 CTFEGCGRRFSLDFNLRTHVRIHTGDKPFVCPFDACNKKFAQSTNLKSHILTHVKNK 373

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pholNP_001287005.1 zf-C2H2 502..526 CDD:278523 13/23 (57%)
COG5048 <504..614 CDD:227381 85/109 (78%)
C2H2 Zn finger 504..526 CDD:275368 13/21 (62%)
zf-C2H2 531..553 CDD:278523 18/21 (86%)
C2H2 Zn finger 533..553 CDD:275368 16/19 (84%)
zf-H2C2_2 546..571 CDD:290200 21/24 (88%)
C2H2 Zn finger 561..583 CDD:275368 20/21 (95%)
zf-H2C2_2 575..602 CDD:290200 19/26 (73%)
C2H2 Zn finger 591..613 CDD:275368 16/21 (76%)
Yy2NP_001364162.1 Mediates transcriptional activation. /evidence=ECO:0000250 36..109 17/63 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 201..220 7/32 (22%)
Mediates transcriptional repression. /evidence=ECO:0000250 241..376 95/251 (38%)
C2H2 Zn finger 263..282 CDD:275368 11/18 (61%)
COG5048 <287..376 CDD:227381 71/87 (82%)
C2H2 Zn finger 289..309 CDD:275368 16/19 (84%)
C2H2 Zn finger 317..339 CDD:275368 20/21 (95%)
C2H2 Zn finger 347..369 CDD:275368 16/21 (76%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D362296at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR14003
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
44.020

Return to query results.
Submit another query.