DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3529 and GGA1

DIOPT Version :9

Sequence 1:	NP_648315.1	Gene:	CG3529 / 39093	FlyBaseID:	FBgn0035995	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_010645.1	Gene:	GGA1 / 851960	SGDID:	S000002766	Length:	557	Species:	Saccharomyces cerevisiae

Alignment Length:	502	Identity:	105/502 - (20%)
Similarity:	197/502 - (39%)	Gaps:	87/502 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 QRIEAATDANLASENWAANMEICDMIN-ESSDTARDAMRAIRKRLSQNAGKNNQVVMYTLTVLET 83
            ::|:.|..:.|...:...|:::.|.|| :...|.|:|:.||.|.::..   :.|..::.|::|:.
Yeast    24 RKIQRACRSTLPEPDLGLNLDVADYINSKQGATPREAVLAIEKLVNNG---DTQAAVFALSLLDV 85

  Fly    84 CVKNCGKAFHVLVAQKDFINELVKLIGPKNDPP---AAMQEKVLSLIQIWAD------AFKNQPD 139
            .|||||.:.|:.:::|:|:|:|||..  ...||   :.:|:.:|..|:.|..      ::|:  |
Yeast    86 LVKNCGYSIHLQISRKEFLNDLVKRF--PEQPPLRYSKVQQMILEAIEEWYQTICKHASYKD--D 146

  Fly   140 LNGVTQMYMELKNKGIEFP---ANDLDAMAP---IYTPQRSVPEMPPQLVAAQQHTI---SPQHM 195
            |..:..|:..||.||..||   :.:|..:.|   :.||.....|......|..:..:   .|..:
Yeast   147 LQYINDMHKLLKYKGYTFPKVGSENLAVLRPNDQLRTPSELQEEQERAQAAKLEELLRSGKPDDL 211

  Fly   196 AAAAAAAAAAAAPPSTGPLHLTPEQAAKLRSELEIVSNNMSILSEMLSVLKPGQESPD-DYALLN 259
            ..|.......|.  ......:..:||  :.:||..:.....:.:|||:    ..:.|| :...:.
Yeast   212 KEANKLMKIMAG--FKDDTKVAVKQA--INNELNKLKRKADLFNEMLT----SADEPDLENEAIQ 268

  Fly   260 ELTSTCKEMQSRIVDLIGRVQDDE-LTAEFLRINDELNNVFLRHQRYEKNRSQGQGAGVTSPSAV 323
            ||....|..|.:...||...:||: |.:...:.||.:..:..|::..:..:.:
Yeast   269 ELYGDLKSAQPKFKKLIEEERDDDALVSNLSKFNDLVIQLLKRYKSIKGMKEE------------ 321

  Fly   324 LGAAMGLPGVGAAGAGATTV----ATLPPPPTTTAVSNTPQS-DQLLIDLIESSEEAQLPQSLGQ 383
               .:.:|...........:    .|....|:.|:.|.:.|. |.||.|             ..:
Yeast   322 ---ELNVPDTNEPAKELNLIDFDDDTTANTPSVTSPSKSLQPFDDLLGD-------------FNK 370

  Fly   384 ISLGGGAPIGVQRSARPADEFDMLAQSRTDGNHKSDLLRDIPSVDAAAGSVTATASPYKPN--QP 446
            :||.         |.:...|.|.:.....|.:.||..: |:...|:..|......|.|..:  .|
Yeast   371 VSLS---------SPKSPQENDTVVDILGDAHSKSSGI-DLLDFDSQPGESKTALSAYSNSIVLP 425

  Fly   447 QQAQRSAGEPPVVSKSTKENEIDEMEAWLGSSHIEGIEELTSSEFDK 493
            .....|:.....::..::.:.:::      |.|:....|||.....|
Yeast   426 NGLLNSSSNSKEITAQSQRHILNQ------SDHLRIDYELTRESMTK 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3529	NP_648315.1	VHS_Tom1	17..158	CDD:239623	42/147 (29%)
CG3529	NP_648315.1	GAT_TOM1_like	222..307	CDD:260091	19/86 (22%)
GGA1	NP_010645.1	VHS_GGA_fungi	22..160	CDD:340795	40/142 (28%)
		GGA_N-GAT	195..222	CDD:408115	3/26 (12%)
		GAT_GGA_fungi	233..320	CDD:410583	21/92 (23%)
		Alpha_adaptinC2	443..555	CDD:397151	6/30 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341413
Domainoid	1	1.000	74	1.000	Domainoid score	I2155
eggNOG	1	0.900	-	-		E1_KOG1087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	96	1.000	Inparanoid score	I1492
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000599
OrthoInspector	1	1.000	-	-		otm46737
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2130
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.820