DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3529 and gga1

DIOPT Version :9

Sequence 1:	NP_648315.1	Gene:	CG3529 / 39093	FlyBaseID:	FBgn0035995	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001004000.2	Gene:	gga1 / 798361	ZFINID:	ZDB-GENE-040822-13	Length:	635	Species:	Danio rerio

Alignment Length:	519	Identity:	114/519 - (21%)
Similarity:	202/519 - (38%)	Gaps:	88/519 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 RIEAATDANLASENWAANMEICDMINESSDTARDAMRAIRKRLSQNAGKNNQVVMYTLTVLETCV 85
            ||..||:......:|.:....||.::...:..:.|.|.:..::.   .......:..|.||||||
Zfish    13 RINKATNPLNRETDWESIQLFCDQLSNEPEGPQLATRLLAHKIQ---SPQEWEAIQALMVLETCV 74

  Fly    86 KNCGKAFHVLVAQKDFINELVKLIGPK---NDPPAAMQEKVLSLIQIWADAFKNQPDLNGVTQMY 147
            |||||.||..|.:..|:|||:|::.||   :..|..:::|||.::..|..:.   |:...::..|
Zfish    75 KNCGKRFHNEVGKFRFLNELIKVVSPKYLGSRAPEPVKKKVLEMMYSWTVSL---PEETKISDAY 136

  Fly   148 MELKNKGI-----EFPANDLDAMAPIYTPQRSV--PEMPPQLVAAQQHTISPQHMAAAAAAAAAA 205
            ..||.:||     :.| :|.....|...|:.::  .|...::::...::..|:.:.||.......
Zfish   137 QMLKKQGIIKQDPDLP-DDKPCPPPPPRPKNAIFEDEEKSKMLSRLLNSSHPEDLRAANKLIKEM 200

  Fly   206 AAPPSTGPLHLTPEQAAKLRSELEIVSNNMSILSEMLSVLKPGQESPDDYALLNELTSTCKEMQS 270
            ......     ..|:.:|..:.::.|..::.:|:::|........|..:..|:.:|...|::|:.
Zfish   201 VQEDQK-----RMEKVSKRVNAIQEVKESVGLLTQLLGDYSKDSSSQSNEELIKDLYQRCEKMRP 260

  Fly   271 RIVDLIGRVQD-DELTAEFLRINDELNNVF-LRHQRYEKNRSQGQGAGVTSPSAVLGAAMGLPGV 333
            .:..|....:| ||..||.|:.||.|..|. |..|........|:.:...:......|.:.|.|
Zfish   261 TLFRLASDTEDNDEALAEILQANDSLTQVINLYRQLVRGEEVNGEASSSATHPGSSNALLDLTG- 324

  Fly   334 GAAGAGATTVATLPPPPTTTAVSNTP-QSDQLLIDLIESSEEAQLPQSLGQISLGGGAPIGVQRS 397
                        |...|:..:.|..| |:.:|.|.|::
Zfish   325 ------------LDTSPSAQSFSEFPSQTQELGISLLD--------------------------- 350

  Fly   398 ARPADEFDMLAQSRTDGNHKSDLLRDIPSVDAAAGSVTATASPYKPNQPQQA----QRSAGEPPV 458
                ||...|..:..:.|..|....|....:....|.|...    |..|:.|    ..||.:.||
Zfish   351 ----DELMSLGLTEVNSNLTSSQSGDAMGWNTFQSSETEDT----PVMPEPAVLLPVTSATKTPV 407

  Fly   459 VSKSTKENEIDEMEAWLGSSHI------EGIEELTSSEFDKFLEERAAAAENLPTISASNSAAS 516
            ....|....:||::. ||.:.:      ||::    .::||...:......:|...|.:|:|.|
Zfish   408 PVPVTSTKSLDELDL-LGKTLLQQSLPPEGLQ----VKWDKLQSQSKPTLRDLQIKSGNNAATS 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3529	NP_648315.1	VHS_Tom1	17..158	CDD:239623	42/144 (29%)
CG3529	NP_648315.1	GAT_TOM1_like	222..307	CDD:260091	22/86 (26%)
gga1	NP_001004000.2	VHS_GGA	9..147	CDD:239624	42/139 (30%)
		GAT_GGA1_GGA2	210..298	CDD:260097	22/87 (25%)
		Alpha_adaptinC2	513..627	CDD:197886
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2130
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940