DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3529 and Gga2

DIOPT Version :9

Sequence 1:	NP_648315.1	Gene:	CG3529 / 39093	FlyBaseID:	FBgn0035995	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_083034.1	Gene:	Gga2 / 74105	MGIID:	1921355	Length:	603	Species:	Mus musculus

Alignment Length:	478	Identity:	116/478 - (24%)
Similarity:	209/478 - (43%)	Gaps:	70/478 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 IEAATDANLASENWAANMEICDMINESSDTARDAMRAIRKRLSQNAGKNNQVVMYTLTVLETCVK 86
            :..|||.::|.::|:|..:.|:.:|........|...:..::.....|.   .:|.|||||.|:.
Mouse    33 LNKATDPSMAEQDWSAIQKFCEQVNTDPSGPTHAPWLLAHKIQSPQEKE---ALYALTVLEICMN 94

  Fly    87 NCGKAFHVLVAQKDFINELVKLIGPKNDPPAAMQE---KVLSLIQIWADAFKNQPDLNGVTQMYM 148
            :||:.||..||:..|:|||:|::.||.....|.::   :|:.::..|...|   |:...:...|.
Mouse    95 HCGEKFHSEVAKFRFLNELIKVLSPKYLGAWATEKVKGRVIEILFSWTVWF---PEDIKIRDAYQ 156

  Fly   149 ELKNKGI--EFPANDLDAMAPIYTP-QRSV---PEMPPQLVAAQQHTISPQHMAAAAAAAAAAAA 207
            .||.:||  :.|...:|.:.|..:| .:|:   .|...:|:.....:..|:.:.||.....
Mouse   157 MLKKQGIIKQDPKLPMDKILPPPSPWPKSIFDADEEKSKLLTRLLKSNHPEDLQAANRLIK---- 217

  Fly   208 PPSTGPLHLTPEQAAKLR------SELEIVSNNMSILSEMLSVL-KPGQESPDDYALLNELTSTC 265
                   :|..|:..|..      |.:|.|.:::.:|.||||:. :||...||..| |..:...|
Mouse   218 -------NLVKEEQEKSEKVSRRVSAVEEVRSHVRVLREMLSMYRRPGHALPDQQA-LQVVYERC 274

  Fly   266 KEMQSRIVDLIG-RVQDDELTAEFLRINDELNNVFLRHQRYEKNRSQGQ-GAGVTSPSAV--LGA 326
            ::::..:..|.. ...||:..||.|:.||.|.    :..|..|...:|: .||...|:||  :.|
Mouse   275 EKLRPTLFRLASDTTDDDDALAEILQANDLLT----QGVRLYKQVVEGRVSAGNAVPAAVGAIPA 335

  Fly   327 AMGLPGVGAAGAGA-----TTVATLPPPPTTTAVSNTPQSDQLLIDLIESSEEAQLPQSLGQISL 386
            ....|.....|...     .|.:.|........:::.|..:|::|.  ....:.:.|   |.|:|
Mouse   336 PRAFPNPEPCGLNCPLIDLETPSLLHQDLAALGINDVPTRNQVVIP--SCCNDKKQP---GAITL 395

  Fly   387 GGGAPIGVQRSARPADEFDMLAQSRTDG-NH--KSDLLRDIPSVDAA-------AGSV-TATASP 440
            .||   |:|..:...:..|:.:...:.| |:  :..:.:::|....|       ||.: ::|||.
Mouse   396 MGG---GIQSLSADRNLLDLFSPQPSPGLNYVPQKSIPKEVPPGTKASPGWSWEAGPLASSTASQ 457

  Fly   441 YKPNQ----PQQAQRSAGEPPVV 459
            ..|..    |.::.:.:..||:|
Mouse   458 NTPLAHVFVPLESVKPSSLPPIV 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3529	NP_648315.1	VHS_Tom1	17..158	CDD:239623	40/140 (29%)
CG3529	NP_648315.1	GAT_TOM1_like	222..307	CDD:260091	26/92 (28%)
Gga2	NP_083034.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		VHS_GGA2	29..166	CDD:340807	40/138 (29%)
		GGA_N-GAT	187..226	CDD:375735	7/49 (14%)
		GAT_SF	229..317	CDD:383514	26/92 (28%)
		Unstructured hinge	318..473		34/162 (21%)
		Alpha_adaptinC2	481..595	CDD:197886	116/478 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831181
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2130
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.870